Ndị na-ahụ maka biomarkers maka Atrophic Gastritis na-adịghị ala ala: Ọganihu nyocha

Gastritis na-adịghị ala ala (CAG) bụ ọrịa afọ na-adịghị ala ala nke a na-eji nwayọọ nwayọọ na-efunahụ mucosal glands yana mbelata ọrụ afọ. Dị ka ọkwa dị mkpa nke ọnya afọ na-aga n'ihu, nchọpụta mmalite na nlekota nke CAG dị oke mkpa maka igbochi mmepe nke ọrịa kansa afọ. N'ime akwụkwọ a, anyị ga-atụle isi biomarkers ugbu a iji chọpụta ma nyochaa CAG na uru ngwa ngwa ha.

I. Serologic BioMarkers

1. Pepsinogen (PG)NkePGⅠ/PGⅡ oke (PGⅠ/PGⅡ) bụ akara serologic kacha eji eme ihe maka CAG.

• Mbelata ọkwa nke PGⅠ na PGⅠ/PGⅡA na-ejikọta oke nke ukwuu na ogo nke atrophy ahụ gastric.
• Ntuziaka ndị Japan na ndị Europe etinyela ule PG na mmemme nyocha ọrịa kansa afọ

2.Gastrin-17 (G-17)

• Na-egosipụta ọnọdụ ọrụ endocrine nke sinus gastric.
• Mbelata na atrophy nke sinus gastric ma nwee ike ịbawanye na atrophy nke ahụ gastric.
• Ejikọtara ya na PG iji kwalite izi ezi nchọpụta CAG

3.Anti-Parietal Cell Antibodies (APCA) na Anti-Intrinsic Factor Antibodies (AIFA)

• Ihe nrịbama pụrụ iche maka gastritis autoimmune.
• Na-enyere aka n'ichepụta gastritis autoimmune na ụdị CAG ndị ọzọ

2. Histological Biomarkers

1. CDX2 na MUC2
   • Ngwakọta mbinye aka nke chemotaxis intestinal
   • Nkwalite na-egosi eriri afọ mucosal.
2. p53 na Ki-67
   • Ndị na-egosi mmụba cell na ihe dị iche iche na-adịghị mma.
   • Nyere aka nyochaa ihe ize ndụ cancer na CAG.
3. Helicobacter pylori (H. pylori)-Akara ndị metụtara
   • Nchọpụta ihe na-akpata nje dị ka CagA na VacA.
   • Urea ume iku ume (UBT) na stool antigen test.

3. Ndị na-ahụ maka ihe ndị dị ndụ na-apụta

1. microRNA
   • miR-21, miR-155 na ndị ọzọ ka egosipụtara nke ọma na CAG
   • Enwere ike ịchọpụta ọrịa na uru amụma.
2. DNA Methylation Markers
   • Ụdị methylation na-adịghị mma na mpaghara ndị na-akwalite nke mkpụrụ ndụ ihe nketa ụfọdụ
   • Ọnọdụ methylation nke mkpụrụ ndụ ihe nketa dị ka CDH1 na RPRM
3. Metabolomic Biomarkers
   • Mgbanwe na profaịlụ metabolite akọwapụtara na-egosipụta ọnọdụ nke mucosa gastric
   • Echiche ọhụrụ maka nchọpụta na-abụghị nke mbuso agha

4. Ngwa Clinical na Echiche Ọdịnihu

Nnwale jikọtara ọnụ nke ndị na-ahụ maka biomarkers nwere ike imeziwanye nghọta na nkọwapụta nke nchoputa CAG. N'ọdịnihu, nyocha nke multi-omics agbakwunyere na-atụ anya na ọ ga-enye nchikota nke biomarkers nke ọma maka ederede ziri ezi, stratification ihe ize ndụ na nlekota nke CAG n'otu n'otu.

Anyị Baysen Medical ọkachamara na nyocha na mmepe nke diagnostic reagents maka ọrịa usoro nri digestive, na mepụtara.PGⅠ, PGⅡ naG-17 Ngwa nyocha nke dabere na oke uche na nkọwapụta, nke nwere ike ịnye ngwaọrụ nyocha a pụrụ ịdabere na ya maka CAG na ụlọ ọgwụ. Anyị ga-aga n'ihu na-agbaso ọganihu nyocha na mpaghara a ma kwalite ngwa ntụgharị asụsụ nke ihe nrịbama ọhụrụ.