Te Hononga i waenganui i te Ate Ngako me Iniurinī

Ko te Hononga i waenga i te Ate Ngako me te Insulin Glycated he hononga tata i waenga i te ate ngako (ina koa ko te mate ate ngako kore-waipiro, NAFLD) meinihurini(raneiinihurinite ātete, te hyperinsulinemia), e pāngia ana e ngā mate pāwera (hei tauira, te momona, te momo 2mate huka,me ētahi atu). Koinei te tātaritanga taipitopito o ngā kōrero matua:

1. IniurinīTe Ātete hei Tikanga Matua

• IniurinīKo te ātete (IR) he pūtake mate noa mō te ate momona me te pākia o te huka toto. Ina heke te aro o te tinana ki te insulin, ka nui ake te huna a te repe taiakiinihurini(hyperinsulinemia), ka hua ake he nui ake ngā taumata insulin i roto i te toto.
• Ngā hua o te ate momona: ateinihuriniKa ārai te ātete i te waikura o te waikawa ngako, ka whakatairanga i te hanganga ngako (te whakatakotoranga lipid), ā, ka whakanui ake i te kohikohinga o te ngako i roto i ngā hepatocytes (steatosis).
• Te hononga kiHbA1cAhakoa ehara te insulin glycated i te tohu haumanu e whakamahia whānuitia ana, ka piki ake te hemoglobin glycated i te hyperglycemia roa (e hono ana ki te IR).(HbA1c), e whakaatu ana i te ngoikore o te whakahaere huka toto, e pā ana ki te haere whakamua o te ate momona ki te steatohepatitis kore-waipiro (NASH).

2. Ka Whakatairangahia e te Hyperinsulinemia te Mate Ate Ngako

• Mahi tika: Ka whakatairangahia e te hyperinsulinemia te lipogenesis ate (↑ te hanganga lipid) mā te whakahohe i ngā take whakawhiti (hei tauira, SREBP-1c) me te aukati i te β-oxidation o te waikawa ngako.
• Pānga Ā-kore:IniurinīNā te ātete ka tukuna e te kiko ngako he nui ake ngā waikawa ngako kore utu (FFA), ka uru ki te ate, ka hurihia hei triglycerides, ka kino ake te ate ngako.

3. Ka whakanui ake te Ate Ngako i te pākia o te huka toto

• I puta mai i te ateIniurinīĀtete: Ka tukuna e te ate ngako ngā cytokine mumura (hei tauira, TNF-α,IL-6) me ngā adipokines (hei tauira, te ātete leptin, te hekenga o te adiponectin), ka kino haere te ātete insulin pūnaha.
• Te pikinga o te putanga huka toto i roto i te ate:inihuriniNā te ātete, kāore e taea e te ate te aukati tika i te gluconeogenesis, ā, ka kino ake te pākia o te huka toto nohopuku e te nui haere o te huka toto (tērā pea ka piki haere ki te mate huka momo 2).

4. Ngā Taunakitanga Hauora:Hemoglobin Glycosylated (HbA1c)me te Ate Ngako

• Mā te HbA1c teitei ka tohu i te mōrearea o te ate momona: kua whakaatuhia e ētahi rangahauHbA1cHe hononga pai ngā taumata ki te kaha o te ate momona, ahakoa kāore i tutuki ngā paearu tātaritanga mate huka (ka nui ake te mōrearea mēnā he HbA1c ≥ 5.7%).
• Te Whakahaere Taupūnga Huka i roto i ngā Tūroro Ate Ngako: Ko ngā tūroro mate huka me te ate ngako me whakahaere pea i te huka toto kia kaha ake (kia iti ake ngā whāinga HbA1c) hei whakaroa i te haere whakamua o te mate ate.

5. Ngā Rautaki Wawaotanga: Te Whakapai AkeIniurinīTe aro nui

• Ngā whakarerekētanga o te momo noho: te whakahekenga taumaha (mā te whakahekenga taumaha 5-10% ka pai ake te ate momona), te kai iti-warowaihā/iti-ngako, te whakakori tinana.
• Ngā rongoā:
  • Ite insulinsKa taea e ngā rongoā whakarei ake i te tinana (hei tauira, metformin, pioglitazone) te whakapai ake i te ate ngako me te pākia o te huka.
  • Ka āwhina ngā agonists receptor GLP-1 (hei tauira, te liraglutide, te semaglutide) ki te whakaheke taumaha, te whakahaere glycemic, me te whakaheke i te ate ngako.
• Te Aroturuki: Te Nohopukuinihurini, i whakamātauria auautia te HOMA-IR (taupū ātete insulin), te HbA1c me te whakaahua/elastography ate.

Whakamutunga

Ate momona me te inihurini (te hyperinsulinemia rānei) ka hanga i tētahi huringa kino mā te ātete ki te insulin. Te wawaotanga wawe oinihuriniKa whakapai ake te ātete i te pākia o te ate ngako me te huka toto, ā, ka whakaiti i te mōrearea o te mate huka me te fibrosis ate. Me aromatawai ngātahi ngā tohu pākia i roto i te whare hauora, kaua e aro ki te tohu kotahi anake.

Ko mātou o Baysen Medical e arotahi tonu ana ki ngā tikanga tātaritanga hei whakapai ake i te kounga o te oranga. E rima ngā tūāpapa hangarau kua whakawhanakehia e mātou - Latex, koura colloidal, Fluorescence Immunochromatographic Assay, Molecular, Chemiluminescence Immunoassay, ā mātouWhakamātautau HbA1c,Whakamātautau insulinmeWhakamātautau C-peptide he ngawari te whakahaere, ā, ka taea te whiwhi hua whakamātautau i roto i te 15 meneti