Biomarkers for Chronic Atrophic Gastritis: Zopititsa patsogolo Kafukufuku

Chronic Atrophic Gastritis (CAG) ndi matenda osatha am'mimba omwe amadziwika ndi kutayika pang'onopang'ono kwa tiziwalo timene timatulutsa m'mimba komanso kuchepa kwa ntchito ya m'mimba. Monga gawo lofunikira la zotupa zam'mimba zam'mimba, kuzindikira koyambirira ndikuwunika kwa CAG ndikofunikira kuti tipewe kukula kwa khansa ya m'mimba. Mu pepalali, tikambirana za biomarkers zomwe zikugwiritsidwa ntchito pozindikira ndi kuwunika CAG ndi kufunikira kwawo kwachipatala.

I. Serologic BioMarkers

1. Pepsinogen (PG)ThePGⅠ/PGⅡ chiwerengero (PGⅠ/PGⅡ) ndiye cholembera cha serological chomwe chimagwiritsidwa ntchito kwambiri pa CAG.

• Kuchepetsa milingo ya PGⅠ ndi PGⅠ/PGⅡchiŵerengero kwambiri zogwirizana ndi mlingo chapamimba thupi atrophy.
• Malangizo aku Japan ndi ku Europe aphatikiza kuyesa kwa PG pamapulogalamu owunika khansa ya m'mimba

2.Gastrin-17 (G-17)

• Imawonetsa magwiridwe antchito a endocrine m'mimba yam'mimba.
• Kuchepa kwa atrophy ya chapamimba sinus komanso kutha kuwonjezereka kwa atrophy ya m'mimba.
• Kuphatikizidwa ndi PG kukonza kulondola kwa matenda a CAG

3.Anti-Parietal Cell Antibodies (APCA) ndi Anti-Intrinsic Factor Antibodies (AIFA)

• Zolemba zenizeni za autoimmune gastritis.
• Zothandiza kusiyanitsa autoimmune gastritis ndi mitundu ina ya CAG

2. Histological Biomarkers

1. CDX2 ndi MUC2
   • Siginecha ya molekyulu ya m'matumbo chemotaxis
   • Kuwongolera kumawonetsa matumbo a m'mimba mucosal.
2. p53 ndi Ki-67
   • Zizindikiro za kuchuluka kwa maselo ndi kusiyana kwachilendo.
   • Thandizani kuyesa chiopsezo cha khansa mu CAG.
3. Helicobacter pylori (H. pylori)-Zolemba Zogwirizana
   • Kuzindikira zinthu za virulence monga CagA ndi VacA.
   • Kuyesa kwa mpweya wa Urea (UBT) ndi kuyesa kwa antigen.

3. Zolemba za Molecular Biomarkers

1. ma microRNA
   • miR-21, miR-155 ndi ena amawonetsedwa molakwika mu CAG
   • Kuthekera kwa matenda ndi tsogolo labwino.
2. DNA Methylation Markers
   • Makhalidwe olakwika a methylation m'magawo olimbikitsa a majini ena
   • Mkhalidwe wa methylation wa majini monga CDH1 ndi RPRM
3. Metabolomic Biomarkers
   • Kusintha kwa mbiri ya metabolite kumawonetsa mkhalidwe wam'mimba mucosa
   • Malingaliro atsopano a matenda osasokoneza

4. Ntchito Zachipatala ndi Zowona Zamtsogolo

Kuyesa kophatikizana kwa ma biomarkers kumatha kupititsa patsogolo chidwi komanso kutsimikizika kwa matenda a CAG. M'tsogolomu, kusanthula kophatikizana kwa ma omics kukuyembekezeka kupatsanso kuphatikiza kopitilira muyeso kwa ma biomarkers kuti alembe mwatsatanetsatane, kusanja kwachiwopsezo komanso kuwunika payekhapayekha kwa CAG.

Ife Baysen Medical timakhazikika pakufufuza ndi kupanga zida zowunikira matenda am'mimba, ndipo tapangaPGⅠ, PGⅡ ndiG-17 zida zoyeserera zoyeserera zokhala ndi chidwi komanso tsatanetsatane, zomwe zimatha kupereka zida zodalirika zowunikira CAG m'chipatala. Tipitiliza kutsatira momwe kafukufuku akuyendera m'gawoli ndikulimbikitsa kumasulira kwa zolembera zatsopano.