Ibinyabuzima byerekana indwara ya Gastrite idakira: Iterambere ryubushakashatsi

Indwara ya Gastrite idakira (CAG) ni indwara isanzwe idakira yo mu gifu irangwa no gutakaza buhoro buhoro imvubura zo mu nda no kugabanuka kw'imikorere ya gastric. Nkicyiciro cyingenzi cyibisebe byigifu, gusuzuma hakiri kare no gukurikirana CAG nibyingenzi mukurinda kanseri yigifu. Muri iyi nyandiko, tuzaganira kuri biomarkers yingenzi ikoreshwa mugupima no kugenzura CAG nagaciro kayo kavuriro.

I. Ibimenyetso bya Serologiya

1. Pepsinogen (PG)UwitekaPGⅠ / PGⅡ igipimo (PGⅠ / PGⅡ) nikimenyetso gikoreshwa cyane muri serologique ya CAG.

• Kugabanuka kurwego rwa PGⅠ na PGⅠ / PGⅡigipimo gifitanye isano cyane nurwego rwa gastrica atrophy.
• Amabwiriza y’Ubuyapani n’Uburayi yashyizwemo kwipimisha PG muri gahunda yo gusuzuma kanseri yo mu gifu

2.Gastrin-17 (G-17)

• Yerekana imikorere ya endocrine imikorere ya sinus gastric.
• Kugabanuka kwa atrophy ya sinus gastric kandi birashobora kwiyongera muri atrophy yumubiri wigifu.
• Hamwe na PG kugirango utezimbere CAG kwisuzumisha neza

3. Antibodies za Anti-Parietal Cell (APCA) na Antibodiyite Zirwanya Imbere (AIFA)

• Ibimenyetso byihariye bya autoimmune gastritis.
• Ifasha mugutandukanya gastrite ya autoimmune nubundi bwoko bwa CAG

2. Ibinyabuzima byerekana amateka

1. CDX2 na MUC2
   • Umukono wa molekile ya chemotaxis yo munda
   • Kwiyongera byerekana gastric mucosal intestinalisation.
2. p53 na Ki-67
   • Ibipimo byo gukwirakwiza selile no gutandukana bidasanzwe.
   • Fasha gusuzuma ibyago bya kanseri muri CAG.
3. Helicobacter pylori (H. pylori)-Ibimenyetso bifitanye isano
   • Kumenya ibintu bya virusi nka CagA na VacA.
   • Ikizamini cyo guhumeka Urea (UBT) hamwe na test ya antigen.

3. Ibinyabuzima bigenda byiyongera

1. microRNAs
   • miR-21, miR-155 nabandi bagaragazwa neza muri CAG
   • Ibishoboka byo gusuzuma no kumenya agaciro.
2. Ibimenyetso bya Methylation ya ADN
   • Uburyo bwa methylation budasanzwe mubice biteza imbere genes zimwe na zimwe
   • Imiterere ya methylation ya gen nka CDH1 na RPRM
3. Metabolomic Biomarkers
   • Impinduka muburyo bwihariye bwa metabolite yerekana imiterere ya mucosa gastric
   • Ibitekerezo bishya byo kwisuzumisha bidateye

4. Amavuriro akoreshwa hamwe nigihe kizaza

Kwipimisha hamwe kubimenyetso bya biomarkers birashobora kunoza cyane ibyiyumvo byihariye nibisobanuro bya CAG. Mu bihe biri imbere, isesengura ryinshi-omics riteganijwe gutanga ibisobanuro birambuye bya biomarkers kugirango wandike neza, ibyiciro bishobora guterwa no kugenzura buri muntu ku giti cye.

Twebwe ubuvuzi bwa Baysen kabuhariwe mubushakashatsi no guteza imbere reagents zo gusuzuma indwara zifata igifu, kandi twateye imberePGⅠ, PGⅡ naG-17 bishingiye ku gufatanya gupima ibikoresho bifite sensibilité nini kandi yihariye, bishobora gutanga ibikoresho byizewe byo gusuzuma CAG mumavuriro. Tuzakomeza gukurikirana iterambere ryubushakashatsi muriki gice kandi dutezimbere ikoreshwa ryubuhinduzi bwibimenyetso bishya.