Ibimenyetso by'ubuzima bw'umuntu ku ndwara ya Atrophic Gastritis idakira: Iterambere mu bushakashatsi

Indwara ya Atrophic Gastritis (CAG) ni indwara idakira ikunze kugaragara mu gifu irangwa no gutakaza buhoro buhoro imiyoboro y'igifu no kugabanuka k'imikorere y'igifu. Nk'icyiciro cy'ingenzi cy'ibisebe byo mu gifu mbere yo kurwara kanseri, gusuzuma no gukurikirana CAG hakiri kare ni ingenzi mu gukumira kanseri y'igifu. Muri iyi nyandiko, tuzaganira ku bimenyetso by'ingenzi bikoreshwa mu gusuzuma no kugenzura CAG n'akamaro kayo mu buvuzi.

I. Ibipimo by'ibinyabuzima bya Serologic

1. Pepsinogen (PG)ItsindaPGⅠ/PGⅡ igipimo (PGⅠ/PGⅡ) ni cyo kimenyetso cya serologic kikoreshwa cyane kuri CAG.

• Kugabanuka kw'ibipimo bya PGⅠ na PGⅠ/PGⅡigipimo gifitanye isano rikomeye n'urugero rwo kugabanuka k'umubiri w'igifu.
• Amabwiriza y'Ubuyapani n'Uburayi yashyizemo gupima PG muri gahunda zo gupima kanseri y'igifu

2.Gastrin-17 (G-17)

• Igaragaza imikorere y'uturemangingo tw'inda mu misemburo.
• Kugabanuka kwa sinus y'igifu kandi bishobora kwiyongera kwa kwangirika k'igifu.
• Bihujwe na PG kugira ngo byongere ubuhanga mu gusuzuma CAG

3. Anti-Parietal Cell Antibodies (APCA) na Anti-Intrinsic Factor Antibodies (AIFA)

• Ibimenyetso byihariye byerekana indwara ya gastritis iterwa n'ubwiyongere bw'umubiri.
• Ifasha mu gutandukanya indwara ya gastritis iterwa n'ubwiyongere bw'umubiri n'izindi ndwara za CAG

2. Ibimenyetso by'ibinyabuzima by'amateka

1. CDX2 na MUC2
   • Molekile y'ingenzi ya chemotaxis y'amara
   • Kuzamuka kw'igifu bigaragaza ko amara ye yahindutse mu mucosa.
2. p53 na Ki-67
   • Ibimenyetso by'ubwiyongere bw'uturemangingo n'itandukaniro ridasanzwe.
   • Fasha gusuzuma ibyago byo kurwara kanseri muri CAG.
3. Helicobacter pylori (H. pylori)-Ibimenyetso bifitanye isano
   • Gutahura ibintu bitera ubukana nka CagA na VacA.
   • Ikizamini cyo guhumeka kwa Urea (UBT) n'ikizamini cya antigen y'umwanda.

3. Ibimenyetso by'ibinyabuzima bya molekile bikiri bishya

1. mikoroRNA
   • miR-21, miR-155 n'izindi zigaragazwa mu buryo butunguranye muri CAG
   • Agaciro gashoboka ko gusuzuma no guhanura indwara.
2. Ibirango bya Methylation ya ADN
   • Imiterere idasanzwe ya methylation mu turere duteza imbere imiterere y'uturemangingo tumwe na tumwe
   • Imiterere ya Methylation ya genes nka CDH1 na RPRM
3. Ibimenyetso by'ibinyabuzima bya metabolomic
   • Impinduka mu miterere yihariye ya metabolite zigaragaza imiterere y'umuyoboro w'igifu
   • Ibitekerezo bishya byo gusuzuma indwara zitari indwara

4. Ikoreshwa mu buvuzi n'ibitekerezo by'ejo hazaza

Gupima hamwe ibipimo ngenderwaho bishobora kongera cyane ubushobozi bwo kumenya no gusesengura CAG. Mu gihe kizaza, isesengura rya multi-omics ryitezweho gutanga uburyo burambuye bwo gupima ibipimo ngenderwaho kugira ngo habeho kwandika neza, gushyira mu byiciro ingaruka no kugenzura CAG ku giti cyayo.

Twebwe Baysen Medical twibanda ku bushakashatsi no guteza imbere ibikoresho byo gusuzuma indwara z’igogora, kandi twateye imberePGⅠ, PGⅡ naG-17 ibikoresho byo gupima hamwe bifite ubushobozi bwo gupima no kugaragaza imiterere yihariye, bishobora gutanga ibikoresho byizewe byo gusuzuma CAG mu ivuriro. Tuzakomeza gukurikirana iterambere ry’ubushakashatsi muri uru rwego no guteza imbere ikoreshwa ry’ibimenyetso bishya mu guhindura ubuhinduzi.