Biomarkers for Chronic Atrophic Gastritis: Tsvagiridzo Kufambira mberi

Chronic Atrophic Gastritis (CAG) chirwere chisingaperi chisingaperi chegastric chirwere chinoratidzwa nekurasikirwa zvishoma nezvishoma kwegastric mucosal glands uye kuderera kwegastric function. Senhanho yakakosha yegastric precancerous maronda, kuongororwa kwekutanga uye kuongororwa kweCAG kwakakosha kudzivirira kukura kwegomarara remudumbu. Mubepa rino, tichakurukura iyezvino makuru biomarkers anoshandiswa kuongorora nekutarisa CAG uye kukosha kwavo kwekiriniki yekushandisa.

I. Serologic BioMarkers

1. Pepsinogen (PG)ThePGⅠ/PGⅡ chiyero (PGⅠ/PGⅡ) ndiyo inonyanya kushandiswa serologic marker yeCAG.

• Kuderera kwemazinga e PGⅠ uye PGⅠ/PGⅡchiyero chakabatana zvakanyanya nehuwandu hwegastric body atrophy.
• Nhungamiro dzeJapan neEuropean dzakasanganisira kuongororwa kwePG muzvirongwa zvegomarara remudumbu

2.Gastrin-17 (G-17)

• Inoratidza endocrine kushanda mamiriro egastric sinus.
• Kuderera mu atrophy ye gastric sinus uye inogona kuwedzera mu atrophy ye gastric body.
• Yakasanganiswa nePG kuvandudza CAG yekuongorora kurongeka

3.Anti-Parietal Cell Antibodies (APCA) uye Anti-Intrinsic Factor Antibodies (AIFA)

• Makaka chaiwo e autoimmune gastritis.
• Inobatsira mukusiyanisa autoimmune gastritis kubva kune mamwe marudzi eCAG

2. Histological Biomarkers

1. CDX2 uye MUC2
   • Siginecha molecule ye intestinal chemotaxis
   • Upregulation inoratidza gastric mucosal intestinal.
2. p53 uye Ki-67
   • Zviratidzo zvekuwedzera kwemasero uye kusiyanisa kusina kujairika.
   • Batsira kuongorora njodzi yegomarara muCAG.
3. Helicobacter pylori (H. pylori)-Related Markers
   • Kuonekwa kwehutachiona zvinhu zvakaita seCagA uye VacA.
   • Urea breath test (UBT) uye stool antigen test.

3. Emerging Molecular Biomarkers

1. microRNAs
   • miR-21, miR-155 uye mamwe anoratidzwa zvisirizvo muCAG
   • Inogona kuongororwa uye prognostic kukosha.
2. DNA Methylation Markers
   • Abnormal methylation mapatani munzvimbo dzinosimudzira dzemamwe majini
   • Methylation chimiro chemajini akadai seCDH1 uye RPRM
3. Metabolomic Biomarkers
   • Shanduko mune chaiyo metabolite profiles inoratidza mamiriro egastric mucosa
   • Mazano matsva ekuongororwa kweasina-invasive

4. Clinical Applications uye Ramangwana Maonero

Kuongororwa kwakasanganiswa kwema biomarkers kunogona kuvandudza zvakanyanya kunzwa uye kujeka kweCAG kuongororwa. Mune ramangwana, iyo yakasanganiswa yakawanda-omics ongororo inotarisirwa kupa yakazara yakazara musanganiswa weiyo biomarker yekunyatso typing, njodzi stratification uye yakasarudzika yekutarisa CAG.

Isu Baysen Medical inyanzvi mukutsvagisa uye kuvandudza kwema diagnostic reagents ezvirwere zvekugaya system, uye takagadziraPGⅠ, PGⅡ uyeG-17 based co-testing kits ine high sensitivity uye yakananga, iyo inogona kupa yakavimbika yekuongorora maturusi eCAG mukiriniki. Ticharamba tichitevera kufambira mberi kwetsvakiridzo mundima ino uye nekusimudzira mashandisirwo eshanduro emamwe mamakisi ane hutsva.