Zviratidzo zveAtrophic Gastritis: Kufambira Mberi muKutsvagurudza

Chirwere cheAtrophic Gastritis (CAG) chirwere chinowanzoitika chemudumbu chinoratidzwa nekurasikirwa zvishoma nezvishoma kwemagland emudumbu uye kudzikira kwebasa remudumbu. Sedanho rakakosha remaronda emudumbu asati aita kenza, kuongororwa nekukurumidza uye kutariswa kweCAG kwakakosha pakudzivirira kukura kwekenza yemudumbu. Mupepa rino, tichakurukura zviratidzo zvikuru zvemazuva ano zvinoshandiswa kuongorora nekutarisa CAG uye kukosha kwayo mukurapa.

I. Zviratidzo zveSerologic BioMarkers

1. Pepsinogen (PG)IyoPGⅠ/PGⅡ chiyero (PGⅠ/PGⅡ) ndiyo inonyanya kushandiswa serologic marker yeCAG.

• Kuderera kwemazinga e PGⅠ uye PGⅠ/PGⅡchiyero ichi chinoenderana zvakanyanya nehuwandu hwekuora kwemuviri wemudumbu.
• Mitemo yekuJapan neyekuEurope yaisanganisira kuongororwa kwePG muzvirongwa zvekuongorora kenza yemudumbu

2.Gastrin-17 (G-17)

• Inoratidza mashandiro e endocrine e gastric sinus.
• Kudzikira kwekusasimba kwedumbu uye kunogona kuwedzera kusasimba kwedumbu.
• Yakabatanidzwa nePG kuti ivandudze kunyatsoongorora kweCAG

3. Anti-Parietal Cell Antibodies (APCA) uye Anti-Intrinsic Factor Antibodies (AIFA)

• Zviratidzo chaizvo zve autoimmune gastritis.
• Zvinobatsira pakusiyanisa chirwere chegastritis chinokonzerwa nemuviri kubva kune mamwe marudzi eCAG

2. Zviratidzo zveHistological Biomarkers

1. CDX2 neMUC2
   • Morekuru wepamusoro we chemotaxis yemudumbu
   • Kukwidziridzwa kwemudumbu kunoratidza kuti mudumbu mava nedumbu.
2. p53 neKi-67
   • Zviratidzo zvekuwanda kwemasero uye kusiyana kusingawanzoitiki.
   • Batsirai kuongorora njodzi yegomarara muCAG.
3. Helicobacter pylori (H. pylori)-Makaki Akabatana
   • Kuonekwa kwezvinhu zvinokonzera hutachiona zvakaita seCagA neVacA.
   • Kuongororwa kwekufema kweurea (UBT) uye bvunzo yeantigen yetsvina.

3. Zviratidzo zveMamorekuru Zviri Kubuda

1. ma microRNA
   • miR-21, miR-155 nedzimwe dzinoratidzwa zvisina kurongeka muCAG
   • Kukosha kwekuongorora chirwere uye kufanotaura.
2. Zviratidzo zveDNA Methylation
   • Maitiro asina kujairika emethylation munzvimbo dzinosimudzira mamwe majini
   • Mamiriro eMethylation emajini akadai seCDH1 neRPRM
3. Zviratidzo zveBiomarker zveMetabolomic
   • Kuchinja mumaprofiles chaiwo emetabolite kunoratidza mamiriro emudumbu mucosa
   • Mazano matsva ekuongorora chirwere chisingakuvadzi

4. Mashandisirwo Ekiriniki Nemaonero Eramangwana

Kuongororwa kwema biomarker pamwe chete kunogona kuvandudza zvakanyanya kunzwisisika uye kujeka kwekuongororwa kweCAG. Mune ramangwana, ongororo ye multi-omics inotarisirwa kupa musanganiswa wakakwana we biomarkers wekunyora kwakanyatsojeka, kupatsanura njodzi uye kutarisa kwega kwega kweCAG.

Isu Baysen Medical tinonyanya kutsvagisa nekugadzira mishonga yekuongorora zvirwere zvemudumbu, uye takagadziraPGⅠ, PGⅡ uyeG-17 Makiti ekuongorora pamwe chete ane hunhu hwakanyanya uye hunonyatsojeka, izvo zvinogona kupa maturusi ekuongorora eCAG akavimbika mukiriniki. Ticharamba tichitevera kufambira mberi kwekutsvaga munharaunda iyi uye tichikurudzira kushandiswa kwemavara matsva mukushandura.