Biomarkers for Chronic Atrophic Gastritis: Horumarrada Cilmi-baarista

Gastritis Chronic Atrophic Gastritis (CAG) waa cudur caloosha raaga oo caadi ah oo lagu garto inuu si tartiib tartiib ah u lumo qanjidhada xuubka caloosha iyo hoos u dhaca shaqada caloosha. Marxalad muhiim ah oo ah nabarrada kansarka caloosha ku jira, ogaanshaha hore iyo la socodka CAG ayaa muhiim u ah ka hortagga horumarinta kansarka caloosha. Warqadan, waxaan kaga hadli doonaa biomarkers-ka waaweyn ee hadda loo isticmaalo in lagu baaro laguna kormeero CAG iyo qiimahooda codsi caafimaad.

I. Seerologic BioMarkers

1. Pepsinogen (PG)ThePGⅠ/PGⅡ saamiga (PGⅠ/PGⅡ) waa calaamada serologic ee inta badan loo isticmaalo CAG.

• Heerarka hoos u dhaca PGⅠ iyo PGⅠ/PGⅡsaamiga ayaa si weyn ugu xiran heerka atrophy jirka gastric.
• Tilmaamaha Jabbaan iyo reer Yurub ayaa ku daray baaritaanka PG ee barnaamijyada baaritaanka kansarka caloosha

2.Gastrin-17 (G-17)

• Waxay ka tarjumaysaa heerka shaqo ee endocrine sinus-ga caloosha.
• Hoos u dhaca atrophy ee sinus gastric waxaana laga yaabaa inuu kordhiyo atrophy ee jirka gastric.
• Lagu daray PG si loo hagaajiyo saxnaanta ogaanshaha CAG

3. Anti-Parietal Cell Antibodies (APCA) iyo Anti-Intrinsic Factor Antibodies (AIFA)

• Calaamado gaar ah oo loogu talagalay gastritis-ka autoimmune.
• Waxay ku caawinaysaa inay ka soocdo gaastari-jiifka iyo noocyada kale ee CAG

2. Biomarkers Histological

1. CDX2 iyo MUC2
   • Moleekule saxeexa chemotaxis xiidmaha
   • Kordhinta waxay muujinaysaa xiidmaha xabka caloosha.
2. p53 iyo Ki-67
   • Tilmaamayaasha kororka unugyada iyo kala soocida aan caadiga ahayn.
   • Caawi qiimaynta halista kansarka ee CAG.
3. Helicobacter pylori (H. pylori)-Calamadaha la xidhiidha
   • Ogaanshaha arrimaha fayraska sida CagA iyo VacA.
   • Baaritaanka neefta Urea (UBT) iyo baaritaanka antigen-ka saxarada.

3. Biomarkers Molecular Soo baxaya

1. microRNAs
   • miR-21, miR-155 iyo kuwa kale ayaa si aan leexleexad lahayn loogu muujiyay CAG
   • Qiimaha ogaanshaha iyo saadaalinta suurtagalka ah.
2. Calaamadaha Methylation DNA
   • Qaababka methylation-ka aan caadiga ahayn ee gobollada dhiirrigeliye ee hiddo-wadaha qaarkood
   • Heerka methylation ee hiddo-wadaha sida CDH1 iyo RPRM
3. Biomarkers Metabolomic
   • Isbeddellada ku yimaadda astaamaha dheef-shiid kiimikaad gaar ah ayaa ka tarjumaya xaaladda xabka caloosha
   • Fikrado cusub oo loogu talagalay ogaanshaha aan duullaanka ahayn

4. Codsiyada kiliinikada iyo aragtida mustaqbalka

Tijaabada isku dhafan ee biomarkers waxay si weyn u wanaajin kartaa dareenka iyo gaar ahaaneed ee ogaanshaha CAG. Mustaqbalka, falanqaynta isku-dhafan ee multi-omics ayaa la filayaa inay bixiso isku-dhafan aad u dhammaystiran oo biomarkers ah oo si sax ah loogu qorayo, kala-soocidda khatarta iyo la socodka shakhsi ahaaneed ee CAG.

Waxaan Baysen Medical ku takhasusay cilmi baarista iyo horumarinta reagents ogaanshaha cudurada habka dheefshiidka, oo aan horumariyo.PGⅠ, PGⅡ iyoG-17 xirmooyinka isku-dhafka ah ee ku salaysan dareenka sare iyo gaar ahaaneed, kuwaas oo bixin kara qalab baadhiseed oo lagu kalsoonaan karo oo CAG ah ee rugta caafimaadka. Waxaan sii wadi doonaa inaan raacno horumarka cilmi baarista ee goobtan oo aan kor u qaadno codsiga tarjumaada ee calaamado cusub oo badan.