Li-biomarkers bakeng sa Chronic Atrophic Gastritis: Tsoelo-pele ea Lipatlisiso

Chronic Atrophic Gastritis (CAG) ke lefu le tloaelehileng le sa foleng la ka mpeng le khetholloang ke tahlehelo ea butle-butle ea litšoelesa tsa mucosal le ho fokotseha ha tšebetso ea mala. Joalo ka mohato oa bohlokoa oa liso tsa ka mpeng, tlhahlobo ea pele le tlhahlobo ea CAG li bohlokoa bakeng sa ho thibela nts'etsopele ea mofetše oa mala. Leqepheng lena, re tla tšohla li-biomarker tse kholo tsa hajoale tse sebelisoang ho hlahloba le ho beha leihlo CAG le boleng ba ts'ebeliso ea bona ea bongaka.

I. Serologic BioMarkers

1. Pepsinogen (PG)ThePGⅠ/PGⅡ tekanyo (PGⅠ/PGⅡ) ke lesupa la serologic le sebelisoang haholo bakeng sa CAG.

• Maemo a fokotsehileng a PGⅠ le PGⅠ/PGⅡkaro-karolelano li amana haholo le tekanyo ea gastric body atrophy.
• Litaelo tsa Majapane le tsa Europe li kenyelelitse tlhahlobo ea PG mananeong a tlhahlobo ea mofetše oa mala

2.Gastrin-17 (G-17)

• E bonahatsa boemo ba ts'ebetso ea endocrine ea sinus ea gastric.
• Ho fokotseha ha atrophy ea sinus ea gastric ho ka 'na ha eketseha ho fokotseha ha' mele oa gastric.
• E kopantsoe le PG ho ntlafatsa ho nepahala ha tlhahlobo ea CAG

3.Anti-Parietal Cell Antibodies (APCA) le Anti-Intrinsic Factor Antibodies (AIFA)

• Matšoao a khethehileng bakeng sa gastritis ea autoimmune.
• E thusa ho khetholla gastritis ea autoimmune le mefuta e meng ea CAG

2. Li-Biomarker tsa Histological

1. CDX2 le MUC2
   • Molek'hule o saenneng oa chemotaxis ea mala
   • Upregulation e bontša hore gastric mucosal intestinalization.
2. p53 le Ki-67
   • Lipontšo tsa ho ata ha lisele le phapang e sa tloaelehang.
   • Thusa ho lekola kotsi ea mofets'e ho CAG.
3. Helicobacter pylori (H. pylori)-Related Markers
   • Ho sibolloa ha lintlha tsa virulence joalo ka CagA le VacA.
   • Teko ea moea ea Urea (UBT) le tlhahlobo ea antigen ea setuloana.

3. Li-Biomarker tse Hlahang tsa Molecular

1. li-microRNAs
   • miR-21, miR-155 le tse ling li hlahisoa ka mokhoa o fapaneng ho CAG
   • Boleng bo ka bang teng ba tlhahlobo le prognostic.
2. Matšoao a DNA Methylation
   • Mekhoa e sa tloaelehang ea methylation libakeng tse khothalletsang liphatsa tsa lefutso tse itseng
   • Boemo ba methylation ea liphatsa tsa lefutso tse kang CDH1 le RPRM
3. Metabolomic Biomarkers
   • Liphetoho litabeng tse khethehileng tsa metabolite li bonahatsa boemo ba mucosa ea gastric
   • Maikutlo a macha bakeng sa tlhahlobo e sa hlaseleng

4. Likopo tsa Kliniki le Maikutlo a Bokamoso

Teko e kopaneng ea li-biomarker e ka ntlafatsa haholo kutlo le ho nepahala ha tlhahlobo ea CAG. Nakong e tlang, tlhahlobo e kopaneng ea li-multi-omics e lebelletsoe ho fana ka motsoako o felletseng oa li-biomarker bakeng sa ho thaepa ka nepo, stratification ea kotsi le ho beha leihlo CAG ka bomong.

We Baysen Medical re sebetsa ka thata ho etsa lipatlisiso le nts'etsopele ea li-reagents tsa tlhahlobo ea mafu bakeng sa mafu a tsamaiso ea tšilo ea lijo, 'me re ntlafalitsePGⅠ, PGⅡ leG-17 li-kits tsa tlhahlobo tse kopaneng tse nang le kutloelo-bohloko e phahameng le tse ikhethang, tse ka fanang ka lisebelisoa tse tšepahalang tsa tlhahlobo ea CAG tleliniking. Re tla tsoelapele ho latela tsoelopele ea lipatlisiso lefapheng lena le ho khothaletsa ts'ebeliso ea phetolelo ea matšoao a macha.