Li-biomarker tsa Atrophic Gastritis e sa Foleng: Tsoelo-pele ea Lipatlisiso

Chronic Atrophic Gastritis (CAG) ke lefu le tloaelehileng le sa foleng la mpa le khetholloang ke ho lahleheloa butle-butle ha litšoelesa tsa mucosal tsa mpa le ho fokotseha ha ts'ebetso ea mpa. Jwalo ka mohato oa bohlokoa oa liso tsa mpa tse ka bang teng pele ho kankere, ho hlahlojoa kapele le ho beoa leihlo ha CAG ho bohlokoa bakeng sa ho thibela nts'etsopele ea kankere ea mpa. Pampiring ena, re tla buisana ka li-biomarker tse kholo tsa hajoale tse sebelisoang ho hlahloba le ho beha leihlo CAG le boleng ba ts'ebeliso ea eona ea bongaka.

I. Li-biomarker tsa Serologic

1. Pepsinogen (PG)ThePGⅠ/PGⅡ karolelano (PGⅠ/PGⅡ) ke letshwao la serological le sebediswang haholo bakeng sa CAG.

• Maemo a fokotsehileng a PGⅠ le PGⅠ/PGⅡKarolelano e amana haholo le tekanyo ea ho putlama ha 'mele oa mpa.
• Tataiso ea Majapane le ea Europe e kenyelelitse liteko tsa PG mananeong a tlhahlobo ea kankere ea mala

2.Gastrin-17 (G-17)

• E bonts'a boemo ba ts'ebetso ea endocrine ea sinus ea mpa.
• Ho fokotseha ha ho omella ha sinus ea mpa 'me ho ka eketsa ho omella ha' mele oa mpa.
• E kopantsoe le PG ho ntlafatsa ho nepahala ha tlhahlobo ea CAG

3. Li-Anti-Parietal Cell Anti-Parietal (APCA) le Li-Anti-Intrinsic Factor Anti-Intrinsic Factor (AIFA)

• Matšoao a khethehileng a gastritis ea autoimmune.
• E thusa ho khetholla gastritis ea autoimmune ho mefuta e meng ea CAG

2. Litšoao tsa Bio tsa Histological

1. CDX2 le MUC2
   • Molek'hule e ikhethang ea chemotaxis ea mala
   • Ho phahama ha lera la mpa ho bontša ho ruruha ha mucosa ea mpa.
2. p53 le Ki-67
   • Matšoao a ho ata ha sele le phapang e sa tloaelehang.
   • Thusa ho lekola kotsi ea kankere ho CAG.
3. Helicobacter pylori (H. pylori)-Matshwao a Amanang
   • Ho lemoha mabaka a kotsi a kang CagA le VacA.
   • Teko ea ho hema ha urea (UBT) le teko ea antigen ea mantle.

3. Li-biomarker tse hlahang tsa limolek'hule

1. li-microRNA
   • miR-21, miR-155 le tse ling li hlahisoa ka mokhoa o sa tloaelehang ho CAG
   • Boleng bo ka bang teng ba tlhahlobo le bo bolelang esale pele.
2. Matšoao a Methylation ea DNA
   • Mekhoa e sa tloaelehang ea methylation libakeng tse khothalletsang liphatsa tsa lefutso tse itseng
   • Boemo ba methylation ba liphatsa tsa lefutso tse kang CDH1 le RPRM
3. Li-biomarker tsa metabolomic
   • Liphetoho liprofaeleng tse itseng tsa metabolite li bonts'a boemo ba mucosa ea mpa.
   • Mehopolo e mecha bakeng sa tlhahlobo e sa hlaseleng

4. Litšebeliso tsa Bongaka le Maikutlo a Nakong e Tlang

Liteko tse kopaneng tsa li-biomarker li ka ntlafatsa haholo kutloisiso le ho totobala ha tlhahlobo ea CAG. Nakong e tlang, tlhahlobo e kopaneng ea li-omics tse ngata e lebelletsoe ho fana ka motsoako o felletseng oa li-biomarker bakeng sa ho thaepa ka nepo, ho arola likotsi le ho beha leihlo CAG ka bomong.

Re Baysen Medical re ikhethile lipatlisisong le nts'etsopele ea li-reagents tsa tlhahlobo bakeng sa mafu a sistimi ea tšilo ea lijo, 'me re ntlafalitsePGⅠ, PGⅡ leG-17 lisebelisoa tsa tlhahlobo tse thehiloeng ho tsona tse nang le kutloelo-bohloko e phahameng le ho hlaka, tse ka fanang ka lisebelisoa tse tšepahalang tsa tlhahlobo bakeng sa CAG kliniking. Re tla tsoela pele ho latela tsoelo-pele ea lipatlisiso lefapheng lena le ho khothaletsa ts'ebeliso ea phetolelo ea matšoao a macha haholoanyane.