I-C-peptide, okanye i-linking peptide, yi-amino acid ye-short-chain edlala indima ebalulekileyo ekuvelisweni kwe-insulin emzimbeni. Yimveliso ephuma kwimveliso ye-insulin kwaye ikhutshwa yi-pancreas ngokulinganayo ne-insulin. Ukuqonda i-C-peptide kunokubonelela ngengcaciso ebalulekileyo kwiimeko ezahlukeneyo zempilo, ngakumbi isifo seswekile.

Xa ipancreas ivelisa i-insulin, ekuqaleni ivelisa imolekyuli enkulu ebizwa ngokuba yi-proinsulin. I-Proinsulin yahlulwe ibe ziinxalenye ezimbini: i-insulin kunye ne-C-peptide. Nangona i-insulin inceda ukulawula amanqanaba eswekile egazini ngokukhuthaza ukufunxwa kweswekile kwiiseli, i-C-peptide ayinandima ngqo kwi-metabolism yeswekile. Nangona kunjalo, luphawu olubalulekileyo lokuvavanya umsebenzi wepancreas.

Enye yezona ndlela ziphambili zokulinganisa amanqanaba e-C-peptide kukuxilonga nokulawula isifo seswekile. Kubantu abanesifo seswekile sohlobo loku-1, inkqubo yomzimba yokuzikhusela ihlasela kwaye itshabalalise iiseli ze-beta ezivelisa i-insulin kwi-pancreas, nto leyo ebangela amanqanaba aphantsi okanye angafumanekiyo e-insulin kunye ne-C-peptide. Ngokwahlukileyo koko, abantu abanesifo seswekile sohlobo lwesibini badla ngokuba namanqanaba e-C-peptide aqhelekileyo okanye aphezulu kuba imizimba yabo ivelisa i-insulin kodwa ayimelani nemiphumo yayo.

Ukulinganiswa kwe-C-peptide kunokunceda ukwahlula phakathi kwesifo seswekile sohlobo 1 kunye nesohlobo 2, kukhokela izigqibo zonyango, kwaye kujongwe ukusebenza kakuhle konyango. Umzekelo, isigulana esinesifo seswekile sohlobo 1 esenziwa utyando lweseli ye-islet sinokubekwa esweni kwamanqanaba aso e-C-peptide ukuze kuvavanywe impumelelo yenkqubo.

Ukongeza kwisifo seswekile, i-C-peptide iye yafundwa ngeziphumo zayo zokukhusela kwiintlobo ngeentlobo zezicubu. Ezinye izifundo zibonisa ukuba i-C-peptide inokuba neempawu zokulwa nokuvuvukala ezinokunceda ekunciphiseni iingxaki ezinxulumene nesifo seswekile, ezinje ngomonakalo wemithambo-luvo kunye nezintso.

Ukuqukumbela, nangona i-C-peptide ngokwayo ingachaphazeli ngqo amanqanaba eswekile egazini, yi-biomarker exabisekileyo yokuqonda nokulawula isifo seswekile. Ngokulinganisa amanqanaba e-C-peptide, ababoneleli bezempilo banokufumana ulwazi ngomsebenzi we-pancreatic, bahlukanise phakathi kweentlobo zesifo seswekile, kwaye balungiselele izicwangciso zonyango ngokweemfuno zomntu ngamnye.

Thina iBaysen Medical sinayoIkhithi yovavanyo lwe-C-peptide ,Ikhithi yovavanyo lwe-insulinkwayeIkhithi yovavanyo lwe-HbA1Cyesifo seswekile