I-Biomarkers ye-Chronic Atrophic Gastritis: UPhando oluPhambili

I-Chronic Atrophic Gastritis (CAG) sisifo sesisu esingapheliyo esibonakaliswa ngokulahlekelwa kancinci kwamadlala e-gastric mucosal kunye nokuncipha kokusebenza kwesisu. Njengenqanaba elibalulekileyo lezilonda ze-gastric precancerous, ukuxilongwa kwangoko kunye nokujongwa kwe-CAG kubalulekile ekuthinteleni ukukhula komhlaza wesisu. Kweli phepha, siza kuxubusha ii-biomarkers eziphambili ezikhoyo ngoku ezisetyenziselwa ukuxilonga kunye nokubeka iliso kwi-CAG kunye nexabiso labo lesicelo seklinikhi.

I. Serologic BioMarkers

1. I-Pepsinogen (PG)IPGⅠ/PGⅡ umlinganiselo (PGⅠ/PGⅡ) sesona siphawuli seserologic sisetyenziswa kakhulu kwi CAG.

• Ukuncipha kwamanqanaba PGⅠ kunye ne-PGⅠ/PGⅡUmlinganiselo unxulunyaniswa kakhulu neqondo le-atrophy yomzimba wesisu.
• Izikhokelo zaseJapan nezaseYurophu zibandakanya uvavanyo lwe-PG kwiinkqubo zokuhlola umhlaza wesisu

2.I-Gastrin-17 (G-17)

• Ibonisa imeko yokusebenza kwe-endocrine ye-sinus yesisu.
• Ukunciphisa i-atrophy ye-sinus yesisu kwaye kunokunyuka kwi-atrophy yomzimba wesisu.
• Idityaniswe ne-PG ukuphucula ukuchaneka koxilongo lwe-CAG

I-3.I-Anti-Parietal Cell Antibodies (APCA) kunye ne-Anti-Intrinsic Factor Antibodies (AIFA)

• Iimpawu ezithile ze-autoimmune gastritis.
• Uncedo ekwahluleni i-gastritis ye-autoimmune kwezinye iintlobo ze-CAG

2. I-Histological Biomarkers

1. I-CDX2 kunye ne-MUC2
   • Imolekyuli yesiginitsha ye-chemotaxis yamathumbu
   • Ukunyuswa kubonisa ukunyanzeliswa kwe-gastric mucosal intestination.
2. p53 kunye neKi-67
   • Izibonakaliso zokwanda kweeseli kunye nokwahlukana okungaqhelekanga.
   • Uncedo lokuvavanya umngcipheko womhlaza kwi-CAG.
3. IHelicobacter pylori (H. pylori)-Amanqaku anxulumeneyo
   • Ukufunyanwa kwezinto ezinobungozi ezifana neCagA kunye neVacA.
   • Uvavanyo lokuphefumula kwe-Urea (UBT) kunye novavanyo lwe-antigen yesitulo.

3. Ii-Molecular Biomarkers ezisakhulayo

1. iimicroRNAs
   • i-miR-21, miR-155 kunye nezinye zibonakaliswe ngokungaqhelekanga kwi-CAG
   • Ixabiso elinokubakho lokuxilonga kunye neprognostic.
2. Iimpawu zeDNA Methylation
   • Iipateni ze-methylation ezingaqhelekanga kwimimandla ekhuthazayo yeejeni ezithile
   • Ubume be-Methylation yezakhi zofuzo ezifana ne-CDH1 kunye ne-RPRM
3. Iimpawu zeMetabolomic Biomarkers
   • Utshintsho kwiiprofayili ezithile ze-metabolite zibonisa imeko ye-mucosa yesisu
   • Imibono emitsha yoxilongo olungangeneleliyo

4. Izicelo zeklinikhi kunye neembono zexesha elizayo

Uvavanyo oludityanisiweyo lwee-biomarkers lunokuphucula kakhulu ubuntununtunu kunye nokucaciswa kokuxilongwa kwe-CAG. Kwixesha elizayo, uhlalutyo oludityanisiweyo lwe-omics lulindeleke ukuba lunike indibaniselwano ebanzi ngakumbi yeempawu zebhayoloji zokuchwetheza ngokuchanekileyo, ukucwangciswa komngcipheko kunye nokubeka iliso komntu ngamnye kwi-CAG.

Thina iBaysen Medical sisebenza ngokukhethekileyo kuphando kunye nophuhliso lwe-diagnostic reagents yezifo zesistim sokugaya, kwaye sele iphuhlisiwePGⅠ, PGⅡ kwayeG-17 iikiti zokuvavanya ngokubambisana kunye novelwano oluphezulu kunye neenkcukacha ezithile, ezinokubonelela ngezixhobo ezithembekileyo zokuhlola i-CAG kwiklinikhi. Siza kuqhubeka nokulandela inkqubela yophando kule nkalo kwaye sikhuthaze usetyenziso loguqulo lwabamakishi abavelisa izinto ezintsha.