Iimpawu zeBiomarkers ze-Chronic Atrophic Gastritis: Uphando oluPhambili

I-Chronic Atrophic Gastritis (CAG) sisifo esiqhelekileyo sesisu esingapheliyo esibonakaliswa kukulahlekelwa kancinci kancinci kwe-mucosal glands yesisu kunye nokuncipha kokusebenza kwesisu. Njengenqanaba elibalulekileyo lezilonda zesisu ngaphambi komhlaza, ukuxilongwa kwangoko kunye nokubekwa esweni kwe-CAG kubalulekile ekuthinteleni uphuhliso lomhlaza wesisu. Kweli phepha, siza kuxoxa ngeempawu eziphambili zangoku ezisetyenziselwa ukuxilonga nokubeka esweni i-CAG kunye nexabiso layo lesicelo seklinikhi.

I. Ii-Serologic BioMarkers

1. I-Pepsinogen (PG)IPGⅠ/PGⅡ umlinganiselo (PGⅠ/PGⅡ) yeyona nto isetyenziswa kakhulu kwi-serologic marker ye-CAG.

• Amanqanaba anciphileyo I-PGⅠ kunye ne-PGⅠ/PGⅡUmlinganiselo unxulumene kakhulu nomlinganiselo wokuwohloka komzimba wesisu.
• Izikhokelo zaseJapan nezaseYurophu zibandakanye uvavanyo lwe-PG kwiinkqubo zokuhlola umhlaza wesisu

2.I-Gastrin-17 (G-17)

• Ibonisa imeko yokusebenza kwe-endocrine ye-sinus yesisu.
• Ukuncipha kokubola kwesisu esiswini kwaye kunokwanda ukubola komzimba wesisu.
• Idityaniswe ne-PG ukuphucula ukuchaneka kokuxilonga kwe-CAG

3. Ii-Anti-Parietal Cell Antibodies (APCA) kunye nee-Anti-Intrinsic Factor Antibodies (AIFA)

• Iimpawu ezithile ze-autoimmune gastritis.
• Iluncedo ekwahlukaniseni isifo se-autoimmune gastritis kwezinye iintlobo ze-CAG

2. Iibhayomarker zeHistological

1. I-CDX2 kunye ne-MUC2
   • Imolekyuli ephawulekayo ye-chemotaxis yamathumbu
   • Ukunyuka kwesisu kubonisa ukuba isisu siqala ukubila.
2. p53 kunye neKi-67
   • Izalathisi zokwanda kweeseli kunye nokwahlukana okungaqhelekanga.
   • Nceda uvavanye umngcipheko womhlaza kwi-CAG.
3. I-Helicobacter pylori (H. pylori)-Iimpawu eziNxulumeneyo
   • Ukufunyanwa kwezinto ezibangela ubungozi njengeCagA kunye neVacA.
   • Uvavanyo lokuphefumla lwe-urea (UBT) kunye novavanyo lwe-antigen yestool.

3. Ii-Biomarkers zeMolekyuli ezisakhulayo

1. ii-microRNA
   • i-miR-21, i-miR-155 kunye nezinye zibonakaliswa ngendlela engaqhelekanga kwi-CAG
   • Ixabiso elinokubakho lokuxilongwa kunye nelokuxela kwangaphambili.
2. Iimpawu zeMethylation zeDNA
   • Iipateni ze-methylation ezingaqhelekanga kwiindawo ezikhuthazayo zezakhi ezithile zemfuza
   • Isimo seMethylation seejini ezifana neCDH1 kunye neRPRM
3. Iimpawu zeMetabolomic Biomarkers
   • Utshintsho kwiiprofayili ezithile ze-metabolite lubonisa imeko ye-mucosa yesisu
   • Iingcamango ezintsha zokuxilongwa okungengongeneleli

4. Izicelo zeKlinikhi kunye neeMbono zeXesha elizayo

Uvavanyo oludibeneyo lwee-biomarkers lunokuphucula kakhulu ubuntununtunu kunye nokuchaneka kokuxilongwa kwe-CAG. Kwixesha elizayo, uhlalutyo oludibeneyo lwe-multi-omics kulindeleke ukuba lubonelele ngokudibanisa okubanzi ngakumbi kwee-biomarkers zokubhala ngokuchanekileyo, ukwahlulwahlulwa komngcipheko kunye nokubekwa esweni kwe-CAG ngabanye.

Thina iBaysen Medical sigxile kuphando nophuhliso lwezinto ezibangela ukuxilonga izifo zenkqubo yokugaya ukutya, kwaye siye saphuhlisaPGⅠ, PGⅡ kwayeG-17 Iikiti zovavanyo ezisekwe ngokubambisana ezinobuntununtunu obuphezulu kunye nokuchaneka, ezinokubonelela ngezixhobo zokuhlola ezithembekileyo ze-CAG kwiklinikhi. Siza kuqhubeka nokulandela inkqubela yophando kweli candelo kwaye sikhuthaze ukusetyenziswa koguqulelo lweempawu ezintsha ngakumbi.