I-Ferritin: I-Biomarker Esheshayo Nenembile Yokuhlola Ukuntuleka Kwe-Iron kanye Ne-Anemia

Isingeniso

Ukuntuleka kwe-ayoni kanye ne-anemia yizinkinga zezempilo ezivamile emhlabeni wonke, ikakhulukazi emazweni asathuthuka, abesifazane abakhulelwe, izingane kanye nabesifazane abaneminyaka yobudala. I-iron deficiency anemia (IDA) ayithinti nje kuphela umsebenzi womzimba nowokuqonda komuntu ngamunye, kodwa ingase futhi yandise ingozi yezinkinga zokukhulelwa kanye nokulibaziseka kokukhula kwezingane. Ngakho-ke, ukuhlolwa kusenesikhathi nokungenelela kubalulekile. Phakathi kwezinkomba eziningi zokutholwa, i-ferritin isiphenduke ithuluzi elibalulekile lokuhlola ukuntuleka kwensimbi kanye ne-anemia ngenxa yokuzwela kwayo okuphezulu kanye nokucaciswa kwayo. Lesi sihloko sizodingida izici zebhayoloji ye-ferritin, izinzuzo zayo ekuxilongweni kokuntuleka kwe-iron kanye ne-anemia, kanye nenani lesicelo sayo somtholampilo.

Izimpawu Zebhayoloji zeI-Ferritin

I-Ferritiniyiphrotheni yokugcina insimbi etholakala kakhulu ezicutshini zomuntu. Ikhiqizwa ikakhulukazi isibindi, ubende nomnkantsha wamathambo. Umsebenzi wayo oyinhloko ukugcina i-iron nokulawula ibhalansi ye-iron metabolism. Egazini, ukugxila kwei-ferritinihlobene kahle nemithombo yensimbi yomzimba. Ngakho, serumi-ferritinamazinga angenye yezinkomba ezizwela kakhulu zesimo sokugcina insimbi yomzimba. Ngaphansi kwezimo ezijwayelekile, izinga le-ferritin kwabesilisa abadala lingaba ngu-30-400 ng / mL, kanti kwabesifazane liyi-15-150 ng / mL, kodwa esimweni sokuntuleka kwensimbi, leli nani lizoncishiswa kakhulu.

Izinzuzo zeI-FerritinEkuhloleni Ukuntuleka Kwensimbi

1. Ukuzwela okuphezulu, ukutholwa kusenesikhathi kokuntuleka kwensimbi

Ukuthuthukiswa kokuntuleka kwe-iron kuhlukaniswe izigaba ezintathu:

• Isigaba sokuntuleka kwe-iron: insimbi yokugcina(i-ferritin) iyancipha, kodwa i-hemoglobin ijwayelekile;
• Isigaba se-erythropoiesis sokuntuleka kwe-iron:i-ferritiniyancipha ngokwengeziwe, ukugcwala kwe-transferrin kuncipha;
• Isigaba sokuntuleka kwe-iron anemia: i-hemoglobin iyancipha, futhi kuvela izimpawu ezijwayelekile ze-anemia.

Izindlela zokuhlola zendabuko (njengokuhlola i-hemoglobin) zingathola kuphela izinkinga esigabeni se-anemia, kuyilaphoi-ferritinukuhlola kungathola okungavamile esigabeni sokuqala sokuntuleka kwensimbi, ngaleyo ndlela kunikeze ithuba lokungenelela kusenesikhathi.

2. Ukucaciswa Okuphezulu, Ukunciphisa Ukuxilongwa Okungalungile

Izifo eziningi (njengokuvuvukala okungapheli kanye nokutheleleka) zingabangela i-anemia, kodwa azibangelwa ukuntuleka kwensimbi. Kulesi simo, ukuthembela kuphela ku-hemoglobin noma ivolumu ye-corpuscular volume (MCV) kungase kuhlulele imbangela.I-Ferritinukuhlola kungahlukanisa ngokunembile ukuntuleka kwe-iron anemia kwezinye izinhlobo ze-anemia (njenge-anemia yesifo esingelapheki), ukuthuthukisa ukunemba kokuxilonga.

3. Iyashesha futhi ifaneleka, ifanele ukuhlolwa kwenani elikhulu

Ubuchwepheshe besimanje bokuhlola amakhemikhali ezinto eziphilayo benza ukunqunywa kwe-ferritin kusheshe futhi kube ukonga, futhi kufanelekile kumaphrojekthi wezempilo womphakathi afana nokuhlolwa komphakathi, ukunakekelwa kwezempilo komama nezinsana, kanye nokuqapha ukondleka kwezingane. Uma kuqhathaniswa nokuhlolwa okuhlaselayo okufana nokungcolisa insimbi yomnkantsha (izinga legolide), ukuhlolwa kwe-serum ferritin kulula ukukugqugquzela.

Izicelo Zomtholampilo zeFerritin ku-Anemia Management

1. Ukwelashwa kwe-iron supplementation eyisiqondiso

I-Ferritinamazinga angasiza odokotela banqume ukuthi iziguli ziyayidinga yini i-ayoni eyengeziwe futhi baqaphe ukusebenza kokwelashwa. Ngokwesibonelo:

• I-FerritinI-<30 ng/mL: ikhombisa ukuthi izinqolobane zensimbi ziphelile futhi kudingeka ukwengezwa kwensimbi;
• I-Ferritin<15 ng/mL: ikhombisa kakhulu ukuntuleka kwe-iron anemia;
• Uma ukwelashwa kuphumelela, i-ferritin amazinga azokhuphuka kancane kancane futhi angasetshenziswa ukuhlola ukusebenza kahle

1. Ukwengezwa Kwensimbi Eqondisayo

I-Ferritinamazinga asiza odokotela ukuthi babone isidingo sokwelashwa ngensimbi futhi baqaphe ukusebenza kokwelashwa. Ngokwesibonelo:

• I-Ferritin<30 ng/mL: Ibonisa izitolo zensimbi eseziphelile, ezidinga ukwengezwa.
• I-Ferritin<15 ng/mL: Iphakamisa kakhulu ukuntuleka kwe-iron anemia.
• Ngesikhathi sokwelashwa, ukukhuphukai-ferritinamazinga aqinisekisa ukuphumelela kokwelapha.

2. Ukuhlolwa kwenani labantu abakhethekile

• Abesifazane abakhulelwe: isidingo sensimbi siyanda ngesikhathi sokukhulelwa, futhii-ferritinukuhlola kungavimbela izinkinga zomama nezinsana.
• Izingane: ukuntuleka kwensimbi kuthinta ukukhula kwengqondo, futhi ukuhlolwa kusenesikhathi kungathuthukisa ukubikezela.
• Iziguli ezinezifo ezingamahlalakhona: njengeziguli ezinesifo sezinso nesifo samathumbu esivuvukalayo,i-ferritin kuhlanganiswe ne-transferrin saturation ingahlonza uhlobo lwe-anemia.

Imikhawulo yeI-FerritinUkuhlola Nezixazululo

Nakuba i-ferritin iyinkomba ekhethwayo yokuhlolwa kokuntuleka kwensimbi, idinga ukuhunyushwa ngokuqapha kwezinye izimo:

• Ukuvuvukala noma ukutheleleka:I-Ferritin, njenge-acute phase reactant protein, ingase iphakanyiswe ngamanga ekuthelelekeni, isimila noma ukuvuvukala okungapheli. Kulokhu, ingahlanganiswa neI-C-reactive protein (CRP) ori-transferrinukugcwaliswa kwesinqumo esiphelele.
• Isifo sesibindi:I-Ferritinezigulini ezine-cirrhosis zingakhula ngenxa yokulimala kwamangqamuzana esibindi futhi zidinga ukuhlolwa kuhlanganiswe nezinye izinkomba ze-iron metabolism.

Isiphetho

I-Ferritinukuhlola sekube yithuluzi elibalulekile lokuhlola ukuntuleka kwensimbi kanye ne-anemia ngenxa yokuzwela kwayo okuphezulu, ukucaciswa kwayo kanye nokuba lula. Ayikwazi nje ukubona ukuntuleka kwe-iron kusenesikhathi futhi igweme ukuqhubeka kwe-anemia, kodwa futhi iqondise ukwelashwa okunembile futhi ithuthukise ukubikezela kwesiguli. Kwezempilo yomphakathi kanye nokusebenza komtholampilo, ukukhuthazwai-ferritin ukuhlola kungasiza ekunciphiseni umthwalo wezifo we-anemia yokuntuleka kwensimbi, ikakhulukazi emaqenjini asengozini enkulu (njengabesifazane abakhulelwe, izingane kanye neziguli ezinezifo ezingelapheki). Ngokuzayo, ngokuthuthuka kobuchwepheshe bokubona,i-ferritin ingase idlale indima enkulu ekuvimbeleni nasekulawuleni i-anemia emhlabeni jikelele.

I-We Baysen Medical ihlale igxile kumasu okuxilonga ukuze sithuthukise izinga lempilo. Senze izinkundla zobuchwepheshe ezi-5- i-Latex, igolide eli-colloidal, i-Fluorescence Immunochromatographic Assay, i-Molecular, i-Chemiluminescence Immunoassay, YethuIkhithi yokuhlola ye-Ferritin ukusebenza okulula futhi angathola umphumela wokuhlolwa emizuzwini eyi-15