ʻO ka fecal calprotectin (FC) kahi protein nakinaki calcium 36.5 kDa e helu ana no 60% o nā protein cytoplasmic neutrophil a hōʻiliʻili ʻia a hoʻāla ʻia ma nā wahi o ka mumū ʻōpū a hoʻokuʻu ʻia i loko o nā feces.

He ʻano waiwai olaola like ʻole ko FC, me nā hana antibacterial, immunomodulatory, a me nā hana antiproliferative. ʻO ka mea nui, pili ka loaʻa ʻana o FC i ka neʻe ʻana o nā neutrophils i loko o ke ala gastrointestinal. No laila, he hōʻailona pono ia o ka mumū ʻōpū e hoʻoholo ai i ke alo a me ke koʻikoʻi o ka mumū i loko o ka ʻōpū.

ʻEhā wale nō ʻanuʻu e pono ai e ulu aʻe mai ka mumū ʻōpū a i ke kanesa: ka mumū ʻōpū -> nā polyp ʻōpū -> adenoma -> ke kanesa ʻōpū. He mau makahiki a he mau makahiki paha kēia kaʻina hana, e hāʻawi ana i nā manawa kūpono no ka nānā mua ʻana i nā maʻi ʻōpū. Eia nō naʻe, no ka mea, ʻaʻole nui ka poʻe e hoʻolohe i ka nānā mua ʻana, ua ʻike ʻia nā hihia he nui o ke kanesa ʻōpū i kahi pae holomua.

Wahi a nā ʻikepili kūpono ma ka home a ma waho, hiki i ka helu ola 5 makahiki o ke kanesa colorectal mua ke piʻi i 90% a i 95%. Inā he carcinoma in situ (ke kahua mua loa), kokoke ka helu ho'ōla i 100%. ʻOi aku ka liʻiliʻi o ka helu ola 5 makahiki o ke kanesa colorectal hope ma mua o 10%. Hōʻike ikaika kēia ʻikepili he mea nui ka nānā mua ʻana no ka hoʻomaikaʻi ʻana i ke ola a me nā helu ho'ōla no nā maʻi me ke kanesa ʻōpū. I kēia manawa, ua manaʻo kekahi poʻe loea e pono i nā kānaka maʻamau ke nānā mua no ke kanesa ʻōpū ma hope o 40 mau makahiki, a ʻo ka poʻe me ka mōʻaukala ʻohana a i ʻole nā ​​​​mea pilikia kiʻekiʻe ʻē aʻe e nānā mua.

Mea hoʻohui ʻike Calprotectinhe huahana ʻeha ʻole, ʻaʻohe invasive, maʻalahi e hana i hoʻohana ʻia e loiloi i ke kiʻekiʻe o ka mumū ʻōpū a kōkua i ka ʻike ʻana i nā maʻi e pili ana i ka mumū ʻōpū (maʻi mumū ʻōpū, adenoma, maʻi ʻaʻai colorectal). Inā maikaʻi ʻole ka hoʻāʻo calprotectin, ʻaʻole pono ʻoe e hana i kahi colonoscopy no kēia manawa. Inā maikaʻi ka hopena o ka hoʻāʻo, mai hopohopo nui. ʻO ka hapa nui o nā hopena post-colonoscopy he mau lesions precancerous e like me adenomas. Hiki ke mālama pono ʻia kēia mau lesions ma o ke komo mua ʻana.