ʻO Pepsinogen Iua hana ʻia a hūnā ʻia e nā cell chief o ka ʻāpana glandular oxyntic o ka ʻōpū, a ua hana ʻia a hūnā ʻia ka pepsinogen II e ka ʻāpana pyloric o ka ʻōpū. Hoʻāla ʻia nā mea ʻelua i nā pepsins i loko o ka lumen gastric e HCl i hūnā ʻia e nā cell parietal fundic.

1. He aha ka pepsinogen II?
ʻO Pepsinogen II kekahi o nā ʻehā aspartic proteinases: PG I, PG II, Cathepsin E a me D. Hoʻopuka nui ʻia ʻo Pepsinogen II ma ka mucosa o ke kelepa Oxyntic o ka ʻōpū, ka antrum gastric a me ka duodenum. Hoʻokuʻu nui ʻia ia i loko o ka lumen gastric a i loko o ke kaʻapuni.
2. He aha nā ʻāpana o ka pepsinogen?
Hoʻokumu ʻia nā Pepsinogens i hoʻokahi kaulahao polypeptide me ke kaumaha molekala o kahi o 42,000 Da. Hoʻohui ʻia a hoʻokuʻu ʻia nā Pepsinogens e nā cell chief gastric o ka ʻōpū kanaka ma mua o ka hoʻololi ʻia ʻana i ka enzyme proteolytic pepsin, he mea nui ia no nā kaʻina hana digestive i loko o ka ʻōpū.
3. He aha ka ʻokoʻa ma waena o ka pepsin a me ka pepsinogen?
He enzyme ʻōpū ʻo Pepsin e lawelawe ana e hoʻoheheʻe i nā protein i loaʻa i ka meaʻai i ʻai ʻia. Hoʻopuka nā pūnaewele aliʻi o Gastric i ka pepsin ma ke ʻano he zymogen hana ʻole i kapa ʻia ʻo pepsinogen. Hoʻopuka nā pūnaewele parietal i loko o ka ʻōpū i ka waikawa hydrochloric e hoʻohaʻahaʻa i ka pH o ka ʻōpū.

Pahu Hōʻailona no ka Pepsinogen I/PepsinogenII (Fluorescence Immuno Assay)He hoʻāʻo immunochromatographic fluorescence no ka ʻike nui ʻana o PGI / PGII i loko o ke serum kanaka a i ʻole plasma, Hoʻohana nui ʻia ia e loiloi i ka hana o nā cell gland oxyntic gastric a me ka maʻi gland fundus mucinous gastric i ka lāʻau lapaʻau.

Welina e hoʻokaʻaʻike no nā kikoʻī hou aku.