Pepsinogen Iinogadzirwa uye inovanzwa nemasero makuru eiyo oxyntic glandular nharaunda yemudumbu, uye pepsinogen II inogadzirwa uye inovanzwa nenzvimbo yepyloric yemudumbu.Ose ari maviri akaiswa kune pepsins mugastric lumen neHCl yakavanzika ne fundic parietal masero.

1. Chii chinonzi pepsinogen II?
Pepsinogen II ndechimwe chezvine aspartic proteinases: PG I, PG II, Cathepsin E uye D. Pepsinogen II inogadzirwa kunyanya muOxyntic gland mucosa yemudumbu, gastric antrum uye duodenum.Inovanzwa kunyanya mugastric lumen uye mukutenderera.
2.Ndezvipi zvikamu zvepepsinogen?
Pepsinogens inoumbwa neketani imwe yepolypeptide ine huremu hwemamorekuru hunosvika 42,000 Da.Pepsinogens inogadzirwa uye inovanzwa zvakanyanya negastric main cell emudumbu remunhu isati yashandurwa kuita proteolytic enzyme pepsin, iyo yakakosha pakugaya maitiro mudumbu.
3.Ndeupi musiyano uripo pakati pepepsin nepepsinogen?
Pepsin ienzyme yemudumbu inoshandira kugaya mapuroteni anowanikwa muchikafu chakadyiwa.Masero makuru eGastric anoburitsa pepsin se zymogen isingashande inonzi pepsinogen.Masero eParietal mukati memukati memudumbu anoburitsa hydrochloric acid inodzikisa pH yemudumbu.

Diagnostic Kit yePepsinogen I/ PepsinogenII (Fluorescence Immuno Assay)is fluorescence immunochromatographic assay yehuwandu hwekuonekwa kwePGI/PGII muserum yevanhu kana plasma, Inonyanya kushandiswa kuongorora gastric oxyntic gland cell function uye gastric fundus mucinous gland chirwere mumakiriniki.

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