Pepsinogen Iihlanganiswa futhi ifihliwe ngamaseli ayinhloko wesifunda se-oxyntic glandular esiswini, futhi i-pepsinogen II ihlanganiswa futhi ifihliwe yisifunda se-pyloric esiswini.Kokubili kwenziwa kusebenze ama-pepsin kulume lwesisu nge-HCl ekhiqizwe amaseli e-parietal fundic.

1.Iyini i-pepsinogen II?
I-Pepsinogen II ingenye ye-aspartic proteinases: PG I, PG II, Cathepsin E kanye no-D. I-Pepsinogen II ikhiqizwa ngokuyinhloko ku-Oxyntic gland mucosa yesisu, i-antrum yesisu kanye ne-duodenum.Ikhiqizwa ikakhulukazi ku-lumen yesisu kanye nokujikeleza.
2. Yiziphi izingxenye ze-pepsinogen?
Ama-Pepsinogens aqukethe iketango elilodwa le-polypeptide elinesisindo samangqamuzana esingaba ngu-42,000 Da.Ama-Pepsinogens ahlanganiswa futhi afihliwe ngokuyinhloko ngamaseli ayinhloko esiswini sesisu somuntu ngaphambi kokuba aguqulwe abe yi-proteolytic enzyme pepsin, ebaluleke kakhulu ezinqubweni zokugaya esiswini.
3.Uyini umehluko phakathi kwe-pepsin ne-pepsinogen?
I-Pepsin iyi-enzyme yesisu esebenza ekugayeni amaprotheni atholakala ekudleni okungenile.Amaseli ayinhloko e-gastric akhiqiza i-pepsin njenge-zymogen engasebenzi ebizwa ngokuthi i-pepsinogen.Amaseli e-Parietal ngaphakathi kolwelwesi lwesisu akhiqiza i-hydrochloric acid eyehlisa i-pH yesisu.

Ikhithi yokuxilonga ye-Pepsinogen I/PepsinogenII (Fluorescence Immuno Assay)i-fluorescence immunochromatographic assay yokutholwa kobuningi be-PGI/PGII ku-serum yomuntu noma i-plasma, Isetshenziselwa kakhulu ukuhlola ukusebenza kweseli ye-oxyntic ye-gastric oxyntic kanye nesifo se-gastric fundus mucinous emtholampilo.

Siyakwamukela koxhumana naye ukuze uthole imininingwane eyengeziwe.