Pepsinogen nke MbụA na-emepụta ma na-ewepụta site na mkpụrụ ndụ isi nke mpaghara glandular oxyntic nke afọ, a na-emepụtakwa pepsinogen II site na mpaghara pyloric nke afọ. A na-eme ka ha abụọ banye na pepsins na lumen afọ site na HCl nke mkpụrụ ndụ fundic parietal na-ewepụta.

1. Gịnị bụ pepsinogen II?
Pepsinogen II bụ otu n'ime proteinases aspartic anọ: PG I, PG II, Cathepsin E na D. A na-emepụta Pepsinogen II karịsịa na mucosa Oxyntic nke afọ, afọ antrum na duodenum. A na-ewepụta ya karịsịa n'ime lumen afọ na n'ime mgbasa ozi.
2. Kedu ihe mejupụtara pepsinogen?
Pepsinogens nwere otu polypeptide yinye nwere oke molekul dị ihe dịka 42,000 Da. A na-emepụta ma na-ewepụta Pepsinogens site na mkpụrụ ndụ afọ mmadụ tupu a gbanwee ya ka ọ bụrụ pepsin, nke dị mkpa maka usoro nri n'afọ.
3.Kedu ihe dị iche n'etiti pepsin na pepsinogen?
Pepsin bụ enzyme afọ nke na-eje ozi iji gbarie protein dị na nri e riri. Mkpụrụ ndụ afọ na-ewepụta pepsin dị ka zymogen na-adịghị arụ ọrụ nke a na-akpọ pepsinogen. Mkpụrụ ndụ parietal dị n'ime afọ na-ewepụta hydrochloric acid nke na-ebelata pH nke afọ.

Ngwa Nchọpụta maka Pepsinogen I/PepinogenII (Fluorescence Immuno Assay)Ọ bụ nnwale immunochromatographic fluorescence maka nchọpụta ọnụọgụ nke PGI/PGII na serum ma ọ bụ plasma mmadụ. A na-ejikarị ya enyocha ọrụ sel oxyntic gland gastric na ọrịa gland mucinous gastric fundus na ọgwụgwọ.

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