Ngā Tohu Koiora mō te Gastritis Atrophic Mau tonu: Ngā Whakatairanga Rangahau

Ko te Chronic Atrophic Gastritis (CAG) he mate puku mau tonu e tohuhia ana e te ngaromanga haere o ngā repe mucosal puku me te ngoikore o te mahi puku. Hei wāhanga nui o ngā whara precancerous puku, he mea nui te tautuhi wawe me te aroturuki i te CAG hei aukati i te whanaketanga o te mate pukupuku puku. I roto i tēnei tuhinga, ka matapakihia e mātou ngā tohu koiora matua e whakamahia ana hei tautuhi me te aroturuki i te CAG me tō rātou uara tono haumanu.

I. Ngā Tohu Koiora Serologic

1. Pepsinogen (PG)TePGⅠ/PGⅡ ōwehenga (PGⅠ/PGⅡ) te tohu serologic e whakamahia whānuitia ana mō te CAG.

• Ngā taumata kua heke iho o PGⅠ me PGⅠ/PGⅡhe hononga nui tō te ōwehenga ki te nui o te ngoikore o te tinana puku.
• Kua whakaurua e ngā aratohu Hapanihi me Ūropi te whakamātautau PG ki ngā kaupapa tirotiro matepukupuku puku

2.Gastrin-17 (G-17)

• E whakaata ana i te āhua mahi endocrine o te sinus gastric.
• Ka heke te memeha o te sinus gastric, ā, ka piki ake pea te memeha o te tinana gastric.
• I honoa ki te PG hei whakapai ake i te tika o te tātaritanga CAG

3. Ngā Paturopi Pūtau Ārai-Parietal (APCA) me ngā Paturopi Ārai-Tauwehe Ā-roto (AIFA)

• He tohu motuhake mō te gastritis autoimmune.
• He āwhina ki te wehewehe i te gastritis autoimmune mai i ētahi atu momo CAG

2. Ngā Tohu Koiora Histological

1. CDX2 me MUC2
   • He ngota motuhake o te chemotaxis puku
   • Ko te whakanui ake i te rahinga e tohu ana i te pikinga o te mumura o te kopu.
2. p53 me Ki-67
   • Ngā tohu o te tipu pūtau me te rerekētanga rerekē.
   • Āwhina ki te aromatawai i te mōrearea o te mate pukupuku i roto i te CAG.
3. Helicobacter pylori (H. pylori)-Ngā Tohu e Pā Ana
   • Te kimi i ngā āhuatanga kaha pēnei i a CagA me VacA.
   • Whakamātautau manawa urea (UBT) me te whakamātautau ira-tūtae.

3. Ngā Tohu Koiora Ngongoi e Puta Ake Ana

1. ngā microRNA
   • Ko te miR-21, miR-155 me ētahi atu e whakaatuhia ana i roto i te CAG i roto i te āhua hē.
   • Te uara pea mō te tātaritanga me te matapae.
2. Ngā Tohu Methylation DNA
   • Ngā tauira methylation rerekē i roto i ngā rohe whakatairanga o ētahi ira
   • Te tūnga methylation o ngā ira pēnei i te CDH1 me te RPRM
3. Ngā Tohu Koiora Metabolomic
   • Ko ngā panonitanga o ngā kōtaha metabolite motuhake e whakaata ana i te āhua o te mucosa puku
   • Ngā whakaaro hou mō ngā tātaritanga kore-whakaekenga

4. Ngā Whakamahinga Hauora me ngā Tirohanga ā-Mārama

Mā te whakamātautau ngātahi i ngā tohu koiora ka tino whakapai ake i te aro me te motuhaketanga o te tātaritanga CAG. I te heke mai, e tūmanakohia ana ka whakaratohia e te tātaritanga maha-omics whakauru he huinga whānui ake o ngā tohu koiora mō te momo tika, te wehewehenga mōrearea me te aroturuki takitahi i te CAG.

He tohunga mātou ko Baysen Medical ki te rangahau me te whakawhanake i ngā matū tātaritanga mō ngā mate o te pūnaha nakunaku, ā, kua whakawhanakehia e mātouPGⅠ, PGⅡ meG-17 ngā kete whakamātautau-tahi e hangai ana ki te aro nui me te motuhaketanga, ka taea te whakarato i ngā taputapu tirotiro pono mō te CAG i roto i te whare hauora. Ka whai tonu mātou i te ahunga whakamua o te rangahau i roto i tēnei mara, ā, ka whakatairanga i te tono whakamaoritanga o ngā tohu auaha ake.