Pepsinogen IAmapangidwa ndi kutulutsidwa ndi maselo akuluakulu a dera la oxyntic glandular la m'mimba, ndipo pepsinogen II imapangidwa ndi kutulutsidwa ndi dera la pyloric la m'mimba. Zonsezi zimayambitsidwa ku pepsins mu lumen ya m'mimba ndi HCl yomwe imatulutsidwa ndi maselo a fundic parietal.

1. Kodi pepsinogen II ndi chiyani?
Pepsinogen II ndi imodzi mwa mapuloteni anayi a aspartic: PG I, PG II, Cathepsin E ndi D. Pepsinogen II imapangidwa makamaka mu mucosa wa Oxyntic gland m'mimba, gastric antrum ndi duodenum. Imatulutsidwa makamaka mu lumen ya m'mimba ndikuyenda kwa magazi.
2. Kodi zinthu zomwe zili mu pepsinogen ndi ziti?
Pepsinogens imakhala ndi unyolo umodzi wa polypeptide wokhala ndi kulemera kwa mamolekyu pafupifupi 42,000 Da. Pepsinogens amapangidwa ndikutulutsidwa makamaka ndi maselo akuluakulu am'mimba a m'mimba mwa munthu asanasanduke enzyme ya proteolytic pepsin, yomwe ndi yofunika kwambiri pakugaya chakudya m'mimba.
3. Kodi kusiyana pakati pa pepsin ndi pepsinogen ndi kotani?
Pepsin ndi enzyme ya m'mimba yomwe imagwira ntchito yogaya mapuloteni omwe amapezeka muzakudya zomwe zadyedwa. Maselo akuluakulu am'mimba amatulutsa pepsin ngati zymogen yosagwira ntchito yotchedwa pepsinogen. Maselo a parietal mkati mwa m'mimba amatulutsa hydrochloric acid yomwe imachepetsa pH ya m'mimba.

Matenda Zida za Pepsinogen I/PepsinogenII (Fluorescence Immuno Assay)Ndi njira yoyesera ya fluorescence immunochromatographic yodziwira kuchuluka kwa PGI/PGII mu seramu ya anthu kapena plasma, imagwiritsidwa ntchito makamaka poyesa ntchito ya maselo a gastric oxyntic gland ndi matenda a gastric fundus mucinous gland m'chipatala.

Takulandirani kuti mulumikizane nafe kuti mudziwe zambiri.