Calprotectin y'amafi (FC) ni poroteyine ihuza kalisiyumu ya 36.5 kDa igizwe na 60% bya poroteyine za cytoplasmic za neutrophil kandi ikusanyirizwa hamwe igakora ahantu amara yabyimbye hanyuma ikajya mu mwanda.

FC ifite imiterere itandukanye ya biyoloji, harimo n’ibikorwa byo kurwanya indwara ziterwa na bagiteri, kurwanya ubudahangarwa bw’umubiri, no kurwanya ikwirakwira ry’imitsi. By’umwihariko, kuba FC ihari bifitanye isano mu buryo bw’umubare n’uko neutrophils zinjira mu nzira y’igifu. Kubwibyo, ni ikimenyetso cy’ingirakamaro cy’ububyimbirwe bw’amara kugira ngo hamenyekane niba ububyimbirwe buri mu mara n’ubukana bwabwo.

Bishobora gufata intambwe enye gusa kugira ngo umuntu agire ikibazo kuva ku kubyimba mu mara kugeza kuri kanseri: kubyimba mu mara -> polyps mu mara -> adenoma -> kanseri y'amara. Iyi gahunda ifata imyaka cyangwa imyaka ibarirwa muri za mirongo, itanga amahirwe ahagije yo gusuzuma indwara z'amara hakiri kare. Ariko, kubera ko abantu benshi batita ku gusuzuma hakiri kare, abantu benshi barwaye kanseri y'amara basuzumwa bageze ku rwego rwo hejuru.

Dukurikije amakuru yemewe yo mu gihugu no mu mahanga, igipimo cy’imyaka 5 yo kubaho kanseri y’inkondo y’umura mu gihe cy’intangiriro gishobora kugera kuri 90% kugeza kuri 95%. Iyo ari kanseri ikiri mu cyiciro cya mbere (intangiriro ya mbere), igipimo cyo gukira kiri hafi 100%. Igipimo cy’imyaka 5 yo kubaho kanseri y’inkondo y’umura mu gihe cy’intangiriro iri munsi ya 10%. Aya makuru agaragaza cyane ko gupimwa hakiri kare ari ingenzi mu kunoza uburyo bwo kubaho no gukira kw’abarwayi ba kanseri y’inkondo y’umura. Kuri ubu, impuguke zimwe na zimwe zatanze igitekerezo cy’uko abantu basanzwe bagomba gupimwa hakiri kare kanseri y’inkondo y’umura nyuma y’imyaka 40, kandi abantu bafite amateka y’umuryango cyangwa izindi mpamvu zikomeye zo kuba bafite ibyago byinshi byo kurwara kanseri bagomba gupimwa hakiri kare.

Agakoresho ko gutahura Calprotectinni umuti udaca ububabare, udatera indwara, woroshye gukoresha ukoreshwa mu gusuzuma urwego rw'ububyimbirwe bw'amara no gufasha mu gusuzuma indwara ziterwa n'ububyimbirwe bw'amara (indwara y'ububyimbirwe bw'amara, adenoma, kanseri y'inkondo y'umura). Niba ikizamini cya calprotectin kigaragaje ko ari kibi, ntugomba gukora isuzuma ry'inkondo y'umura kugeza ubu. Niba igisubizo cy'ikizamini cyagaragaje ko ari cyiza, ntugire ubwoba bwinshi. Ibisubizo byinshi nyuma ya colonoscopy ni ibisebe byabanje kubyara kanseri nka adenoma. Ibi bibyimba bishobora gucungwa neza binyuze mu gutera inkunga hakiri kare.