Fecal calprotectin (FC) ipuroteni inosunga calcium ye36.5 kDa iyo inoumba 60% yemapuroteni e cytoplasmic e neutrophil uye inounganidzwa uye inovhurwa panzvimbo dzekuzvimba kwemudumbu yoburitswa mutsvina.

FC ine zvinhu zvakasiyana-siyana zvehupenyu, zvinosanganisira mabasa ekurwisa mabhakitiriya, ekudzivirira muviri, uye ekudzivirira kukura kwezvirwere. Kunyanya, kuvapo kweFC kunoenderana nehuwandu hwema neutrophils anopinda mudumbu. Nokudaro, chiratidzo chinobatsira chekuzvimba kwemudumbu kuti uone kuvapo uye kuoma kwekuzvimba mudumbu.

Zvinongotora matanho mana chete kuti zviitike kubva pakuzvimba kwemudumbu kusvika kukenza: kuzvimba kwemudumbu -> mapundu emudumbu -> adenoma -> kenza yemudumbu. Maitiro aya anotora makore kana makumi emakore, zvichipa mikana yakakwana yekuongororwa kwezvirwere zvemudumbu nekukurumidza. Zvisinei, nekuda kwekuti vanhu vazhinji havanyatso tarisiri kuongororwa nekukurumidza, zviitiko zvakawanda zvekenza yemudumbu zvinoonekwa padanho repamusoro.

Zvinoenderana neruzivo rwakavimbika rwemuno nekunze kwenyika, huwandu hwevanhu vanorarama makore mashanu ekenza yemudumbu iri padanho rekutanga hunogona kusvika 90% kusvika 95%. Kana iri carcinoma iri panzvimbo (danho rekutanga), huwandu hwevanhu vanorapwa hunosvika 100%. Huwandu hwevanhu vanorarama makore mashanu ekenza yemudumbu iri padanho rekupedzisira husingasviki 10%. Ruzivo urwu runoratidza zvakasimba kuti kuongororwa kwekutanga kwakakosha pakuvandudza huwandu hwevanhu vanorarama nekenza yemudumbu. Parizvino, vamwe nyanzvi vakataura kuti vanhuwo zvavo vanofanira kuongororwa kenza yemudumbu iri padanho rekutanga mushure memakore makumi mana, uye vanhu vane nhoroondo yemhuri kana zvimwe zvinhu zvine njodzi huru vanofanira kuongororwa nekukurumidza.

Calprotectin detection reagentmushonga usingarwadzi, usingapindi, uri nyore kushandisa unoshandiswa kuongorora huwandu hwekuzvimba kwemudumbu uye kubatsira mukuongorora zvirwere zvine chekuita nekuzvimba kwemudumbu (chirwere chemudumbu chinoputika, adenoma, kenza yemudumbu). Kana bvunzo yecalprotectin isina kunaka, haufanirwe kuita colonoscopy parizvino. Kana mhinduro yebvunzo iine chokwadi, usanyanya kutya. Zvizhinji zvemhedzisiro yepost-colonoscopy maronda asati aita kenza akadai seadenomas. Maronda aya anogona kugadziriswa zvinobudirira kuburikidza nekupindira nekukurumidza.