Pepsinogen IInogadzirwa uye inoburitswa nemasero makuru enzvimbo ye oxyntic glandular yemudumbu, uye pepsinogen II inogadzirwa uye inoburitswa nenharaunda ye pyloric yemudumbu. Ose ari maviri anobatidzwa ku pepsins mu gastric lumen ne HCl inoburitswa ne fundic parietal cells.

1. Chii chinonzi pepsinogen II?
Pepsinogen II ndeimwe yemaproteinase mana e-aspartic: PG I, PG II, Cathepsin E naD. Pepsinogen II inogadzirwa zvakanyanya muOxyntic gland mudumbu, gastric antrum neduodenum. Inobudiswa zvakanyanya mudumbu uye muropa.
2. Ndezvipi zvikamu zvepepsinogen?
Pepsinogens ine cheni imwe chete yepolypeptide ine huremu hwemamorekuru hunosvika 42,000 Da. Pepsinogens inogadzirwa uye inoburitswa zvakanyanya nemasero makuru emudumbu remunhu isati yashandurwa kuita proteolytic enzyme pepsin, iyo inokosha pakugaya mudumbu.
3. Musiyano uripo pakati pepepsin nepepsinogen ndeupi?
Pepsin ienzyme yemudumbu inoshanda kugaya mapuroteni anowanikwa muchikafu chinodyiwa. Masero makuru emudumbu anoburitsa pepsin se zymogen isingashande inonzi pepsinogen. Masero eparietal ari mukati medumbu anoburitsa hydrochloric acid inoderedza pH yemudumbu.

Kiti yekuongorora yePepsinogen I/PepsinogenII (Fluorescence Immuno Assay)Iyi inyanzvi yekuongorora immunochromatographic ye fluorescence yekuona huwandu hwePGI/PGII muropa revanhu kana plasma, inonyanya kushandiswa kuongorora mashandiro emasero e oxyntic gland uye chirwere chegastric fundus mucinous gland mukurapa.

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