I-Pepsinogen Iyenziwe kwaye ikhutshwe ziiseli eziphambili zommandla we-oxyntic glandular wesisu, kwaye i-pepsinogen II yenziwe kwaye ikhutshwe ngummandla we-pyloric wesisu. Zombini zisebenza kwi-pepsins kwi-lumen yesisu yi-HCl ekhutshwe ziiseli ze-fundic parietal.

1. Yintoni i-pepsinogen II?
I-Pepsinogen II yenye yeeproteni ezine ze-aspartic: i-PG I, i-PG II, i-Cathepsin E kunye ne-D. I-Pepsinogen II iveliswa ikakhulu kwi-mucosa ye-Oxyntic gland yesisu, i-gastric antrum kunye ne-duodenum. Ikhutshwa ikakhulu kwi-lumen yesisu kwaye ijikeleze igazi.
2. Zeziphi izinto eziyinxalenye ye-pepsinogen?
IiPepsinogens ziqulathe uthotho olunye lwepolypeptide olunobunzima beemolekyuli obumalunga nama-42,000 Da. IiPepsinogens zenziwa kwaye zikhutshwe ikakhulu ziiseli eziphambili zesisu sesisu somntu ngaphambi kokuba ziguqulwe zibe yi-enzyme yeproteolytic pepsin, ebaluleke kakhulu kwiinkqubo zokugaya esiswini.
3. Yintoni umahluko phakathi kwe-pepsin kunye ne-pepsinogen?
I-Pepsin yi-enzyme yesisu enceda ekugayeni iiproteni ezifumaneka ekutyeni okutyiweyo. Iiseli eziphambili zesisu zikhupha i-pepsin njenge-zymogen engasebenziyo ebizwa ngokuba yi-pepsinogen. Iiseli ze-parietal ngaphakathi kwesisu zikhupha i-hydrochloric acid ehlisa i-pH yesisu.

Ikhithi yokuxilonga yePepsinogen I/PepsinogenII (Uvavanyo lweFluorescence Immuno)luvavanyo lwe-fluorescence immunochromatographic lokubona ubungakanani be-PGI/PGII kwi-serum okanye kwi-plasma yomntu, lusetyenziswa kakhulu ukuvavanya umsebenzi weseli ye-oxyntic gland yesisu kunye nesifo se-gastric fundus mucinous gland kwiklinikhi.

Wamkelekile ukuba uqhagamshelane nathi ukuze ufumane iinkcukacha ezithe vetshe.