Ama-Biomarker we-Chronic Atrophic Gastritis: Intuthuko Yocwaningo

I-Chronic Atrophic Gastritis (CAG) yisifo esivamile sesisu esingamahlalakhona esibonakala ngokulahleka kancane kancane kwezindlala ze-gastric mucosal kanye nokuncipha kokusebenza kwesisu. Njengesigaba esibalulekile sezilonda eziyingozi esiswini, ukuhlonzwa kusenesikhathi kanye nokuqapha kwe-CAG kubalulekile ekuvimbeleni ukukhula komdlavuza wesisu. Kuleli phepha, sizoxoxa ngama-biomarker amakhulu amanje asetshenziselwa ukuxilonga nokuqapha i-CAG kanye nenani lesicelo sabo somtholampilo.

I. Serologic BioMarkers

1. I-Pepsinogen (PG)IPGⅠ/PGⅡ isilinganiso (PGⅠ/PGⅡ) umaka we-serologic osetshenziswa kakhulu ku-CAG.

• Amazinga anciphile we I-PGⅠ kanye ne-PGⅠ/PGⅡisilinganiso sihlobene kakhulu nezinga le-gastric body atrophy.
• Imihlahlandlela yaseJapan neyaseYurophu ifake ukuhlolwa kwe-PG ezinhlelweni zokuhlola umdlavuza wesisu

2.I-Gastrin-17 (G-17)

• Ibonisa isimo sokusebenza kwe-endocrine ye-gastric sinus.
• Ukuncipha kwe-atrophy ye-gastric sinus futhi kungase kwande ukuwohloka komzimba wesisu.
• Kuhlanganiswe ne-PG ukuthuthukisa ukunemba kokuxilonga kwe-CAG

3.Ama-Anti-Parietal Cell Antibodies (APCA) kanye nama-Anti-Intrinsic Factor Antibodies (AIFA)

• Omaka abathile be-autoimmune gastritis.
• Iwusizo ekwehlukaniseni i-autoimmune gastritis kwezinye izinhlobo ze-CAG

2. Izimpawu ze-Histological Biomarkers

1. I-CDX2 ne-MUC2
   • I-molecule yesiginesha ye-chemotaxis yamathumbu
   • I-upregulation ibonisa ukuthunjwa kwe-gastric mucosal.
2. p53 kanye ne-Ki-67
   • Izinkomba zokwanda kwamaseli nokuhlukaniswa okungavamile.
   • Siza ukuhlola ingozi yomdlavuza ku-CAG.
3. I-Helicobacter pylori (H. pylori)-Omaka Abahlobene
   • Ukutholwa kwezinto eziyingozi njenge-CagA ne-VacA.
   • Ukuhlolwa kokuphefumula kwe-Urea (UBT) nokuhlolwa kwe-stool antigen.

3. Ama-Molecular Biomarker asafufusa

1. ama-microRNAs
   • i-miR-21, miR-155 nezinye zivezwe ngokungafanele ku-CAG
   • Inani elingaba khona lokuxilonga nelokubikezela.
2. Izimpawu ze-DNA Methylation
   • Amaphethini e-methylation angavamile ezindaweni ezikhuthazayo zezakhi zofuzo ezithile
   • Isimo se-methylation sezakhi zofuzo ezifana ne-CDH1 ne-RPRM
3. Izimpawu ze-Metabolomic Biomarkers
   • Izinguquko kumaphrofayili athile e-metabolite zibonisa isimo se-mucosa yesisu
   • Imibono emisha yokuxilongwa okungahlanyisi

4. Izicelo Zomtholampilo kanye Nemibono Yesikhathi Esizayo

Ukuhlolwa okuhlanganisiwe kwama-biomarker kungathuthukisa kakhulu ukuzwela kanye nokucaciswa kokuxilongwa kwe-CAG. Ngokuzayo, ukuhlaziya okuhlanganisiwe kwe-multi-omics kulindeleke ukuthi kunikeze inhlanganisela ebanzi kakhulu yama-biomarker wokuthayipha okunembayo, ukuhlukaniswa kwengozi kanye nokuqapha komuntu ngamunye kwe-CAG.

I-We Baysen Medical igxile ocwaningweni nasekuthuthukisweni kwama-reagents okuxilongwa kwezifo zesistimu yokugaya ukudla, futhi sesithuthukilePGⅠ, PGⅡ futhiG-17 amakhithi okuhlola ngokuhlanganyela anokuzwela okuphezulu nokucaciswa, okungahlinzeka ngamathuluzi okuhlola athembekile e-CAG emtholampilo. Sizoqhubeka nokulandela inqubekelaphambili yocwaningo kulo mkhakha futhi sikhuthaze ukusetshenziswa kokuhumusha komaka abaqanjwa kabusha.