Ama-Biomarkers e-Chronic Atrophic Gastritis: Ucwaningo Oluthuthukisiwe

I-Chronic Atrophic Gastritis (CAG) iyisifo esivamile sesisu esingamahlalakhona esibonakala ngokulahlekelwa kancane kancane kwezindlala zesisu kanye nokuncipha kokusebenza kwesisu. Njengesigaba esibalulekile sezilonda zesisu ngaphambi komdlavuza, ukuxilongwa kusenesikhathi kanye nokuqapha i-CAG kubalulekile ekuvimbeleni ukuthuthukiswa komdlavuza wesisu. Kuleli phepha, sizoxoxa ngama-biomarker amakhulu amanje asetshenziswa ukuxilonga nokuqapha i-CAG kanye nenani lokusetshenziswa kwayo emtholampilo.

I. Ama-BioMarkers e-Serologic

1. I-Pepsinogen (PG)IPGⅠ/PGⅡ isilinganiso (PGⅠ/PGⅡ) iyisiphawu se-serologic esisetshenziswa kakhulu se-CAG.

• Amazinga anciphile e- I-PGⅠ kanye ne-PGⅠ/PGⅡisilinganiso sihlobene kakhulu nezinga lokuwohloka komzimba wesisu.
• Iziqondiso zaseJapan nezaseYurophu zifake ukuhlolwa kwe-PG ezinhlelweni zokuhlola umdlavuza wesisu

2.I-Gastrin-17 (G-17)

• Ibonisa isimo sokusebenza kwe-endocrine ye-sinus yesisu.
• Kuyancipha ukuwohloka kwe-sinus yesisu futhi kunganda ukuwohloka komzimba wesisu.
• Kuhlanganiswe ne-PG ukuthuthukisa ukunemba kokuxilonga kwe-CAG

3. Ama-Anti-Parietal Cell Antibodies (APCA) kanye nama-Anti-Intrinsic Factor Antibodies (AIFA)

• Izimpawu ezithile ze-gastritis ye-autoimmune.
• Kuyasiza ekuhlukaniseni isifo sofuba esihlasela amasosha omzimba kwezinye izinhlobo ze-CAG

2. Izimpawu Zebhayoloji Ze-Histological

1. I-CDX2 ne-MUC2
   • I-molecule ephawulekayo ye-chemotaxis yamathumbu
   • Ukwanda kwengcindezi yegazi kubonisa ukuvuvukala kwesisu.
2. ikhasi 53 kanye ne-Ki-67
   • Izinkomba zokwanda kwamaseli kanye nokwehluka okungavamile.
   • Siza ekuhloleni ingozi yomdlavuza ku-CAG.
3. I-Helicobacter pylori (H. pylori)Amamaki Ahlobene
   • Ukutholwa kwezinto ezibangela ukutheleleka njenge-CagA kanye ne-VacA.
   • Ukuhlolwa kokuphefumula kwe-urea (UBT) kanye nokuhlolwa kwe-antigen yendle.

3. Ama-Biomarker E-Molecular Akhulayo

1. ama-microRNA
   • i-miR-21, i-miR-155 kanye nezinye zibonakaliswa ngendlela engajwayelekile ku-CAG
   • Inani elingenzeka lokuxilonga kanye nokubikezela.
2. Amamaki e-DNA Methylation
   • Amaphethini e-methylation angajwayelekile ezindaweni zokukhuthazwa kwezakhi zofuzo ezithile
   • Isimo se-Methylation sezakhi zofuzo ezifana ne-CDH1 kanye ne-RPRM
3. Ama-Biomarker e-Metabolomic
   • Izinguquko kumaphrofayili athile e-metabolite zibonisa isimo se-mucosa yesisu
   • Imibono emisha yokuxilonga okungahlaseli

4. Izicelo Zemitholampilo Nemibono Yesikhathi Esizayo

Ukuhlolwa okuhlanganisiwe kwama-biomarker kungathuthukisa kakhulu ukuzwela kanye nokucaciswa kokuxilongwa kwe-CAG. Esikhathini esizayo, ukuhlaziywa okuhlanganisiwe kwama-multi-omics kulindeleke ukuthi kuhlinzeke ngenhlanganisela ephelele yama-biomarker yokuthayipha okunembile, ukuhlukaniswa kwezingozi kanye nokuqapha i-CAG komuntu ngamunye.

Thina iBaysen Medical sigxile ocwaningweni nasekuthuthukisweni kwama-reagent okuxilonga izifo zesistimu yokugaya ukudla, futhi sithuthukisePGⅠ, PGⅡ futhiG-17 Amakhithi okuhlola asekelwe ngokubambisana anokuzwela okuphezulu kanye nokucacile, angahlinzeka ngamathuluzi okuhlola athembekile e-CAG emtholampilo. Sizoqhubeka nokulandela inqubekela phambili yocwaningo kulo mkhakha futhi sikhuthaze ukusetshenziswa kokuhumusha kwamamaki amasha.