HŌʻULUʻULU MANAʻO

Ma ke ʻano he protein pae ʻāwīwī, pili ka serum amyloid A i nā protein heterogeneous o ka ʻohana apolipoprotein, kahi
he kaumaha molekala pili ma kahi o 12000. He nui nā cytokines e pili ana i ka hoʻoponopono ʻana o ka hōʻike ʻana o SAA
i ka pane ʻana o ka pae koʻikoʻi. Hoʻoulu ʻia e interleukin-1 (IL-1), interleukin-6 (IL-6) a me ka tumor necrosis factor-α
(TNF-α), ua synthesized ʻia ʻo SAA e nā macrophages i hoʻāla ʻia a me ka fibroblast i loko o ke ake, nona ka hapalua ola pōkole o
ma kahi o 50 mau minuke. Hoʻopili koke ʻo SAA me ka lipoprotein kiʻekiʻe-density (HDL) i loko o ke koko ma hope o ka synthesis i loko o ke akepaʻa, kahi
pono e hoʻohaʻahaʻa ʻia e ke serum, ka ʻili o ke kelepona a me nā protease intracellular. I ka hihia o kekahi mau ʻano koʻikoʻi a me nā maʻi mau
ka mumū a i ʻole ka maʻi, ʻo ka nui o ka hōʻino ʻana o SAA i loko o ke kino e lohi ana i ka wā e hoʻonui ai ka synthesis,
ka mea e alakaʻi ai i ka piʻi mau ʻana o ka nui o ka SAA i loko o ke koko. He protein pae koke ka SAA a me ka mumū
māka i hana ʻia e nā hepatocytes. E piʻi aʻe ka nui o ka SAA i loko o ke koko i loko o kekahi mau hola ma hope o
ka hiki ʻana mai o ka mumū, a e ʻike ʻia ka nui o ka SAA i ka piʻi ʻana o 1000 mau manawa i ka wā ʻāwīwī
mumū. No laila, hiki ke hoʻohana ʻia ʻo SAA ma ke ʻano he hōʻailona o ka maʻi microbial a i ʻole nā ​​​​​​maʻi like ʻole, kahi
hiki ke maʻalahi i ka ʻike ʻana i ka mumū a me ka nānā ʻana i nā hana therapeutic.

ʻO kā mākou Diagnostic Kit no ka Serum Amyloid A (Fluorescence Immunochromatographic Assay) e pili ana i ka ʻike ʻana o ka antibody i ka serum amyloid A (SAA) i loko o ka serum kanaka / plasma / hāpana koko holoʻokoʻa, a hoʻohana ʻia no ka ʻike kōkua o ka mumū a me ka maʻi a i ʻole ka maʻi.

Welina mai e hoʻokaʻaʻike no nā kikoʻī hou aku inā he hoihoi kāu.