Pepsinogen Ika hangaia, ka hunaia hoki e ngā pūtau matua o te rohe oxyntic glandular o te puku, ā, ka hangaia, ka hunaia hoki te pepsinogen II e te rohe pyloric o te puku. Ka whakahohehia ngā mea e rua hei pepsins i roto i te lumen puku e te HCl i hunaia e ngā pūtau parietal fundic.

1. He aha te pepsinogen II?
Ko te Pepsinogen II tētahi o ngā pūmua aspartic e whā: PG I, PG II, Cathepsin E me D. Ko te Pepsinogen II ka puta tuatahi i roto i te kiriuhi o te repe Oxyntic o te puku, te antrum gastric me te duodenum. Ka tukuna te nuinga ki roto i te lumen gastric me te tohanga toto.
2. He aha ngā wāhanga o te pepsinogen?
Kotahi te mekameka polypeptide o ngā Pepsinogen, ā, tata ki te 42,000 Da te taumaha ngota. Ko ngā pūtau matua o te puku tangata ka hangaia, ka tukuna hoki ngā Pepsinogen i mua i te hurihanga hei whākōkī proteolytic pepsin, he mea nui mō ngā tukanga nakunaku i roto i te puku.
3. He aha te rerekētanga i waenga i te pepsin me te pepsinogen?
Ko te Pepsin he whākōkī puku e mahi ana ki te nakunaku i ngā pūmua e kitea ana i roto i ngā kai e kainga ana. Ka huna e ngā pūtau matua o te puku te pepsin hei zymogen kore mahi e kiia nei ko te pepsinogen. Ka huna e ngā pūtau parietal i roto i te arai o te puku te waikawa hauwaiora e whakaheke ana i te pH o te puku.

Kete Tātaritanga mō te Pepsinogen I/PepsinogenII (Whakamātautau Ārai Mate Puku)He whakamātautau immunochromatographic fluorescence mō te kimi i te PGI/PGII i roto i te toto tangata, i te plasma rānei. E whakamahia ana hei aromatawai i te mahi a ngā pūtau repe oxyntic puku me te mate repe mucinous fundus puku i roto i te haumanu.

Nau mai ki te whakapā mai mō ētahi atu kōrero.