CHIDULE

Monga puloteni ya acute phase, serum amyloid A ndi ya mapuloteni osiyanasiyana a m'banja la apolipoprotein, omwe
ali ndi kulemera kwa mamolekyu pafupifupi 12000. Ma cytokine ambiri amagwira ntchito yolamulira kamvekedwe ka SAA
mu nthawi yofulumira. Zimalimbikitsidwa ndi interleukin-1 (IL-1), interleukin-6 (IL-6) ndi chotupa cha necrosis factor-α
(TNF-α), SAA imapangidwa ndi ma macrophages oyambitsidwa ndi fibroblast m'chiwindi, chomwe chimakhala ndi theka la moyo waufupi wa
pafupifupi mphindi 50. SAA imalumikizana ndi lipoprotein yapamwamba kwambiri (HDL) m'magazi mwachangu ikapangidwa m'chiwindi, zomwe zimapangitsa kuti magazi azigwira ntchito mwachangu.
iyenera kuwonongedwa ndi seramu, pamwamba pa maselo ndi ma protease amkati mwa maselo. Ngati pali matenda enaake oopsa komanso osatha
kutupa kapena matenda, kuchuluka kwa SAA m'thupi kumachepa pang'onopang'ono pamene kupanga kumawonjezeka,
zomwe zimapangitsa kuti kuchuluka kwa SAA m'magazi kukwere mosalekeza. SAA ndi puloteni yotupa komanso yotupa
chizindikiro chomwe chimapangidwa ndi ma hepatocytes. Kuchuluka kwa SAA m'magazi kudzawonjezeka mkati mwa maola angapo pambuyo
kutupa, ndipo kuchuluka kwa SAA kudzawonjezeka nthawi 1000 panthawi yoopsa
kutupa. Chifukwa chake, SAA ingagwiritsidwe ntchito ngati chizindikiro cha matenda a tizilombo toyambitsa matenda kapena kutupa kosiyanasiyana, komwe
zingathandize kuzindikira kutupa ndi kuyang'anira ntchito zochiritsira.

Chida chathu Chodziwira Matenda a Serum Amyloid A (Fluorescence Immunochromatographic Assay) chimagwiritsidwa ntchito pozindikira kuchuluka kwa antibody to serum amyloid A (SAA) mu seramu/plasma/magazi athunthu a anthu, ndipo chimagwiritsidwa ntchito pozindikira kutupa kapena matenda opatsirana mwadzidzidzi komanso kwanthawi yayitali.

Takulandirani kuti mulumikizane nafe kuti mudziwe zambiri ngati muli ndi chidwi.