Ninde ufite ibyago byinshi kuri Sepsis?

Mugihe umuntu wese ashobora kurwara sepsis niba afite infection, amatsinda akurikira afite ibyago byinshi kandi bisaba kwitonda cyane:

1. Impinja n'abasaza: Ikintu rusange kiranga aba bantu ni sisitemu yubudahangarwa idateye imbere. Ubudahangarwa bw'abana bato n'abana bato ntiburakura neza, mugihe sisitemu yubudahangarwa yabasaza igabanuka uko imyaka igenda ishira kandi akenshi iherekezwa nindwara nyinshi zifatika, bikabagora kurwanya neza indwara.
2. Abarwayi bafite Indwara Zidakira: Abarwayi bafite indwara nka diyabete, kanseri, umwijima n'indwara y'impyiko, indwara zidakira zifata ibihaha (COPD) cyangwa VIH / SIDA bafite imbaraga nke zo kurinda umubiri n'imikorere y'ingingo, bigatuma kwandura bishoboka cyane ko bidashoboka.
3. Abantu badafite ubudahangarwa: Muri bo harimo abarwayi ba kanseri batewe na chimiotherapie, abantu bafata immunosuppressants nyuma yo guterwa ingingo, hamwe n’abantu bafite indwara ziterwa na autoimmune, aho sisitemu y’umubiri idashobora kwitabira neza virusi.
4. Abarwayi bafite ihungabana rikomeye cyangwa kubagwa gukomeye: Ku barwayi bafite umuriro mwinshi, ihahamuka rikabije cyangwa ibikorwa bikomeye byo kubaga, inzitizi y’uruhu cyangwa mucosal irasenywa, itanga umuyoboro w’indwara zitera, kandi umubiri ukaba uhangayitse cyane.
5. Abakoresha ibikoresho byubuvuzi bitera: abarwayi bafite catheters (nka catheters yo hagati yimitsi, catheters yinkari), bakoresheje umuyaga uhumeka cyangwa bafite imiyoboro yamazi mumibiri yabo, ibyo bikoresho birashobora guhinduka "shortcuts" kugirango virusi zinjira mumubiri wumuntu.
6. Abantu bafite Indwara ziheruka cyangwa mu bitaro: Cyane cyane ku barwayi barwaye umusonga, kwandura mu nda, kwandura inkari cyangwa kwandura uruhu, niba ubuvuzi butajyanye n'igihe cyangwa butagize ingaruka, ubwandu bushobora gukwirakwira mu maraso kandi bigatera sepsis.

Nigute ushobora kumenya sepsis? Ibyingenzi byingenzi byerekana uruhare runini

Niba abantu bafite ibyago byinshi bagaragaza ibimenyetso bikekwa ko banduye (nk'umuriro, gukonja, guhumeka neza, umuvuduko ukabije w'umutima, no kwitiranya ibintu), bagomba kwihutira kwivuza. Kwipimisha hakiri kare bishingiye ku ruhererekane rw'isuzuma ry’amavuriro n'ibizamini bya laboratoire, muri byo hakaba harimo uburyo butandukanye bwo gupima virusi (IVD) ni “amaso” y'ingenzi y'abaganga.

1. Umuco wa Microbial (Umuco wamaraso) - Gusuzuma "Zahabu Zahabu"
   • Uburyo: Ingero zamaraso yumurwayi, inkari, urusenda, cyangwa ahandi hantu hakekwa ko zanduye zegeranijwe zishyirwa mu macupa arimo umuco w’umuco, hanyuma ugashyirwa mu rwego rwo gushishikariza gukura kwa virusi (bagiteri cyangwa fungi).
   • Uruhare: Iyi ni "zahabu ya zahabu" yo kwemeza sepsis no kumenya nyirabayazana. Iyo virusi imaze guterwa, kwipimisha mikorobe (AST) birashobora gukorwa kugirango bayobore abaganga muguhitamo antibiyotike nziza. Nyamara, imbogamizi nyamukuru ni igihe gisabwa (mubisanzwe amasaha 24-72 kubisubizo), ntabwo bifasha gufata ibyemezo byihutirwa.
2. Kwipimisha Biomarker - Byihuta "Sisitemu yo kumenyesha"
   Kugirango huzuzwe inenge itwara igihe, umuco utandukanye wa biomarker detection reagent ikoreshwa cyane mugupima byihuse.
   • Ikizamini cya Procalcitonin (PCT): Kuri ubu ni biomarker yingenzi kandi yihariye ifitanye isano na sepsis.PCTni poroteyine igaragara ku rwego rwo hasi cyane ku bantu bafite ubuzima bwiza, ariko ikorwa ku bwinshi mu ngingo nyinshi mu mubiri mu gihe cyanduye cyane.PCT isuzuma (mubisanzwe ukoresheje uburyo bwa immunochromatographic cyangwa chemiluminescent) itanga ibisubizo byuzuye mumasaha 1-2. HejuruPCTurwego rwerekana cyane bacteri sepsis kandi irashobora gukoreshwa mugukurikirana imikorere yubuvuzi bwa antibiotique no kuyobora guhagarika.
   • Kwipimisha C-reaction (CRP): CRP ni poroteyine ikaze yiyongera cyane mugusubiza cyangwa kwandura. Mugihe cyunvikana cyane, ntigisobanutse neza kurenzaPCTkuko irashobora kuzamurwa mubihe bitandukanye, harimo kwandura virusi no guhahamuka. Bikunze gukoreshwa bifatanije nibindi bimenyetso.
   • Umubare w'amaraso yera (WBC) na Neutrophil Ijanisha: Iki nikizamini cyibanze cyuzuye cyo kubara amaraso (CBC). Abarwayi ba Sepsis bakunze kwerekana ubwiyongere bugaragara cyangwa kugabanuka muri WBC hamwe nijanisha ryiyongera rya neutrophile (ibumoso). Nyamara, umwihariko wacyo ni muto, kandi ugomba gusobanurwa hamwe nibindi bipimo.
3. Ubuhanga bwo Gusuzuma Molecular - "Abaskuti"
   • Uburyo: Ubuhanga nka Polymerase Chain Reaction (PCR) na Metagenomic Ibikurikira-Ibihe bikurikirana (mNGS). Izi tekinoroji zikoresha primers na probe zihariye (zishobora kugaragara nka "reagent" zateye imbere) kugirango tumenye neza acide nucleic acide (ADN cyangwa RNA).
   • Uruhare: Ntibisaba umuco kandi birashobora kumenya byihuse indwara zitera mumaraso mumasaha, ndetse no kumenya ibinyabuzima bigoye umuco. By'umwihariko iyo imico gakondo itari mibi ariko gukeka kwa clinique bikomeje kuba hejuru, mNGS irashobora gutanga ibimenyetso bifatika byo gusuzuma. Nyamara, ubu buryo buhenze kandi ntibutanga amakuru ya antibiotique.
4. Kwipimisha Lactate - Gupima Urwego "Crisis"
   • Tissue hypoperfusion na hypoxia nibyingenzi kugirango sepsis iterwa no kunanirwa kwingingo. Urwego rwo hejuru rwa lactate ni ikimenyetso cyerekana hypoxia. Ibikoresho byo kwipimisha kuryama byihuse birashobora gupima byihuse plasma ya lactate (muminota mike). Hyperlactatemia (> 2 mmol / L) yerekana cyane uburwayi bukomeye no guhanura nabi, kandi ni ikimenyetso cyingenzi cyo gutangiza ubuvuzi bukomeye.

Umwanzuro

Sepsis ni isiganwa rirwanya igihe. Abageze mu zabukuru, abanyantege nke, abafite ibibazo by’ubuvuzi, n’abafite ubuvuzi bwihariye ni bo bibasirwa n’ibanze. Kuri aya matsinda afite ibyago byinshi, ibimenyetso byose byanduye bigomba kwitonderwa. Ubuvuzi bwa kijyambere bwashyizeho uburyo bwihuse bwo gusuzuma binyuze muburyo butandukanye, harimo imico yamaraso, gupima biomarker nkaPCT/CRP, kwisuzumisha kuri molekuline, no kwipimisha. Muri ibyo, uburyo butandukanye bwo gukora neza kandi bworoshye bwo kumenya ni urufatiro rwo kuburira hakiri kare, kumenyekana neza, no gutabara ku gihe, byongera cyane amahirwe yo kubaho kwabarwayi. Kumenya ingaruka, gukemura ibimenyetso hakiri kare, no kwishingikiriza ku buhanga bugezweho bwo gutahura nintwaro zacu zikomeye zirwanya uyu "mwicanyi utagaragara."