ISISHWANKATHELO

Njengeproteni yesigaba esibukhali, i-serum amyloid A iyinxalenye yeeproteni ezahlukeneyo zosapho lwe-apolipoprotein, ezibizwa ngokuba yi-amyloid.
inobunzima beemolekyuli obumalunga ne-12000. Ii-cytokines ezininzi zibandakanyeka ekulawuleni ukubonakaliswa kwe-SAA
kwimpendulo yesigaba esikhawulezileyo. Ikhuthazwa yi-interleukin-1 (IL-1), i-interleukin-6 (IL-6) kunye ne-tumor necrosis factor-α
(TNF-α), i-SAA yenziwa zii-macrophages ezisebenzayo kunye ne-fibroblast esibindini, esinobomi obufutshane besiqingatha kuphela
malunga nemizuzu engama-50. I-SAA ibophana ne-high-density lipoprotein (HDL) egazini ngokukhawuleza xa idityaniswa esibindini, nto leyo eyenza ukuba
kufuneka yonakaliswe yi-serum, umphezulu weseli kunye neeprotease zangaphakathi kweseli. Kwimeko ethile ebukhali nengapheliyo
ukudumba okanye usulelo, izinga lokuwohloka kwe-SAA emzimbeni ngokucacileyo liyehla ngelixa ukwenziwa kwayo kusanda,
ezikhokelela ekunyukeni okuqhubekayo koxinzelelo lwe-SAA egazini. I-SAA yiprotheni yesigaba esibukhali kunye nokuvuvukala
uphawu olwenziwa yi-hepatocytes. Uxinzelelo lwe-SAA egazini luya kunyuka kwiiyure ezimbalwa emva kokuba
ukudumba, kwaye uxinzelelo lwe-SAA luya kwanda ngokuphindwe kayi-1000 ngexesha lokuhlasela okukhawulezileyo
ukudumba. Ke ngoko, i-SAA ingasetyenziswa njengophawu losulelo lweentsholongwane okanye ukudumba okwahlukeneyo, okuthi
inokunceda ekuxilongweni kokuvuvukala kunye nokubeka esweni imisebenzi yonyango.

Ikhithi yethu yokuxilonga ye-Serum Amyloid A (Fluorescence Immunochromatographic Assay) iyasebenza ekufumaneni i-antibody kwi-serum amyloid A (SAA) kwi-serum/plasma/isampuli yegazi elipheleleyo lomntu, kwaye isetyenziselwa ukuxilongwa konyango oluncedisayo lokudumba okanye usulelo olukhawulezileyo nolungapheliyo.

Wamkelekile ukuba uqhagamshelane nathi ukuze ufumane iinkcukacha ezithe vetshe ukuba unomdla.