Matepukupuku repeure

Ko te mate pukupuku repeure (CRC, tae atu ki te mate pukupuku rectum me te mate pukupuku koroni) tētahi o ngā pukupuku kino noa o te ara kai.

Kua riro te mate pukupuku o te puku o Haina hei "kaikōhuru tuatahi o te motu", tata ki te 50% o ngā tūroro mate pukupuku o te puku e puta ana i Haina, ā, 60% o te hunga waenga me te hunga muri.

Ahakoa te take hou, te mate rānei, kua nui ake te maha o ngā mate pukupuku puku i te mate pukupuku pūkahukahu. Ko te mate pukupuku puku te mea tino ngāwari ki te whakaora i ngā mate pukupuku katoa mā te tirotiro wawe. Koinei te pā tuatahi o te tangata ki te wikitoria i te mate pukupuku. E 5% noa iho o ngā mate pukupuku koroni Hainamana i kitea wawetia, ā, 60-70% o ngā tūroro he mate pukupuku koroni he kōpū lymph, he metastases tawhiti rānei. Ko te auau hokinga mai he teitei ki te 30%.

Ko Hapani me Kōrea ki te Tonga hoki ētahi whenua he nui te mate pukupuku o te puku, engari ko te auau tātaritanga wawe ko te 50-60%, ā, neke atu i te 90% o ngā tūroro ka taea te whakaora. E whakaatu ana ngā rangahau ā-rohe me ā-ao ka taea e ngā mahi tirotiro mate pukupuku koroni te whakaiti i te auau me te mate o te mate pukupuku koroni.

I ngā tau tata nei, haunga a Ūropi, Amerika Te Raki, Hapani, Hingaiapore, Kōrea ki te Tonga, Taiwana, me Hong Kong, kua whakahaerehia ngā tirotiro ā-motu nui e te kāwanatanga. Mā te tirotiro wawe mō te tautuhi i te mate pukupuku o te puku ka taea te whakaora katoa, me te whai tikanga nui ki te hapori me te uara mākete.

He tukanga roa te putanga mai o te mate pukupuku koroni. Mai i ngā polyp ki te hyperplasia rerekē ki te mate pukupuku, he roa te wā e pau ana, ā, he wā tēnei mō te tirotiro i te mate pukupuku koroni. Mā te tirotiro wawe me te wawaotanga whai hua ka taea te whakaiti i te maha o ngā mate pukupuku mā te 60% me te reiti mate mā te 80%.

2, Te hiranga o te calprotectin i roto i te whakamātautau mahi puku

Ko te Calprotectin he pūmua here-konutea i ahu mai i ngā neutrophil me ngā macrophage, me te taumaha ngota o te 36,000, he heterodimer i hangaia e te hononga kore-tauhohenga o ngā mekameka taumaha e rua MRP14 me te mekameka māmā kotahi MRP8, nō te S100. He pūmua whānau.

Mā te rangahau whānui me te whakamana haumanu, he tino aro nui a calprotectin ki te kite i te mate pukupuku koroni, ā, kāore e pāngia e te wāhanga pukupuku, ka kitea i te wā tōmua me te wā kāore he tohu. Ka taea te whakamahi hei tohu mō te tirotiro i te mate pukupuku koroni.

Ko te aro o te fecal calprotectin, te whakamātautau toto huna fecal me te serum CEA mō te mate pukupuku colorectal he 88.51%, 83.91% me te 44.83%. Ko te reiti pai o te whakamātautau toto huna fecal me te serum CEA i roto i ngā tūroro me te wāhanga D me te wāhanga A he iti iho i tērā i roto i ngā tūroro me te wāhanga C me te D. Kāore he rerekētanga nui i roto i te reiti pai o te fecal calprotectin i roto i ngā tūroro me ngā wāhanga rerekē o Dukes.

I eke te aro o te tātaritanga o te fecal calprotectin ki te mate pukupuku rectum ki te 92.7%, ā, i eke te uara matapae kino o te NPV ki te 98.6%. Ko te fecal calprotectin mō te mate pukupuku colorectal, ≥10mm ngā polyp colorectal, ko te uara matapae kino katoa o te NPV i eke ki te 97.2%.

Tae noa mai ki tēnei wā, neke atu i te 20 ngā whenua pērā i te Hononga o Amerika, Peretānia, Kānata, Wīwī, Tiamana, me Huiterangi kua whakamahi i te calprotectin hei tohu nui mō te tirotiro i ngā mate puku mumura me te mate pukupuku i roto i ngā taupori mōrearea nui o ngā mate puku, ā, kua aromatawaihia hoki te mate puku mumura. He whānuitia te whakamahinga o ngā tohu nui e kaha ana, e ora ana hoki i roto i ngā mahi haumanu.

3, Ngā painga o te calprotectin me te toto huna e kitea ana te aromatawai mōrearea mate pukupuku puku

1. He ngāwari ki te whakahaere: kotahi tauira, maha ngā hua whakamātautau
2. Kāore e whakanui ake i te uauatanga o te whakahaere me te utu o te taputapu: kua whakanohoia te taputapu, ā, kua rite ngā taputapu kia rite ki ngā whakaritenga.
3. Teitei o te aro me te motuhaketanga: te taupū mumura, te toto o te puku
4. Te whanaketanga wawe o te wāhanga tirotiro: te whakanui ake i te tūponotanga o te tirotiro mō te adenocarcinoma me ngā polyp
5. He iti te utu mō te kimi i te toto, ka taea te whakamahi hei tango i te wai mai i te colonoscopy
6. Te manawanui: te tirotiro puranga ā-tau

Ngā tohu matua o te mate pukupuku koroni:

Mumura puku – calprotectin, ko te wāhanga Dukes te wāhanga A me te B o ngā tūroro me te whakamātautau toto huna me te reiti CEA pai o te toto he iti ake i ngā tūroro me te wāhanga C me te D, he rerekē ngā wāhanga Dukes o te tūroro, ko te reiti pai o te calprotectin paru he rerekētanga nui.

Te toto o te puku – te toto huna, te transferrin. Ko te toto o te puku e pā ana ki te ngaronga o te toto i roto i te ara puku mō ngā take maha. Ko ngā take noa ko te mumura o te ara puku tonu, te kino ā-ringa, te mate toto, te pukupuku, me ngā mate o roto i te ara puku. Ko te whakamātautau toto huna he tikanga noa, he tikanga nui hoki mō te tautuhi i te toto puku.

4, Tikanga mō te kimi i te calprotectin paru

Ka taea te whakamahi takitahi i tā mātou kete whakamātautau calprotectin (tikanga koura colloidal) hei kimi i te calprotectin i roto i ngā tauira paru tangata. Ka taea hoki te whakamahi me te raupapa WIZ o ngā whakamātautau ārai mate.

Ka taea e te kete whakamātautau calprotectin (fluorescence immunochromatography) te whakatutuki i te kitenga tauanga, ngā uara tau tika, me te whānuitanga rārangi whānui, kia tutuki ai te pānga o te wehewehe i ngā mate puku.

Ka whakamahia te kete whakamātautau toto huna (tikanga koura colloidal) hei kimi i te hemoglobin tangata i roto i ngā paru tangata, he mea e tika ana mō te tautuhi i te toto puku.