Ngomhla we-13 ku-Epreli, ngo-2026 – Kangangeminyaka engaphezu kwekhulu, i-insulin ibisoloko isisiseko solawulo lwesifo seswekile, iguqula ukuxilongwa okubulalayo kube yimeko engapheliyo elawulekayo. Le hormone, eyafunyanwa ngo-1921 nguFrederick Banting noCharles Best, ukususela ngoko isindise izigidi zabantu kwihlabathi liphela.

I-insulin iveliswa ngokwendalo zii-beta cells kwi-pancreas. Isebenza njengesitshixo, ivula iiseli ukuvumela i-glucose evela egazini ukuba ingene kwaye isetyenziswe njengombane. Kubantu abanesifo seswekile sohlobo loku-1, inkqubo yomzimba yokuzikhusela iyawatshabalalisa la ma-beta cells, ishiya umzimba ungakwazi ukuvelisa i-insulin. Abo banesifo seswekile sohlobo lwesibini banokuvelisa i-insulin eyaneleyo okanye bangakwazi ukumelana nemiphumo yayo, nto leyo ekhokelela kumanqanaba aphezulu eswekile egazini.

Ngaphandle konyango lwe-insulin, abantu abanesifo seswekile sohlobo loku-1 bajongene neengxaki ezisongela ubomi ezifana ne-diabetic ketoacidosis (DKA), apho umzimba uqhekeza amafutha ukuze ufumane amandla, uvelise ii-asidi ezinobuthi ezibizwa ngokuba zii-ketones. Iswekile ephezulu egazini engapheliyo inokubangela ukungasebenzi kakuhle kwezintso, ubumfama, umonakalo wemithambo-luvo, kunye nesifo sentliziyo.

Kwiminyaka engama-20 edlulileyo ibone izinto ezintsha ezimangalisayo ekuhanjisweni kwe-insulin. Iipeni ze-insulin ezikrelekrele ngoku ziqhagamshela kwii-apps zeselfowuni, zilandelela iidosi kwaye zinika izikhumbuzo. Iimonitha zeglucose eziqhubekayo (ii-CGM) zibonelela ngokufundwa kweswekile yegazi ngexesha langempela, zilumkisa abasebenzisi ngengozi ephezulu nephantsi. Iinkqubo ze-hybrid closed-loop, ezaziwa ngokuba yiteknoloji ye-pancreas yokwenziwa, zilungisa ngokuzenzekelayo ukuhanjiswa kwe-insulin ngokusekelwe kwidatha ye-CGM, zinciphisa kakhulu umthwalo wengqondo wokwenza izigqibo rhoqo.

Nangona kunjalo, umahluko omkhulu kwihlabathi liphela usaqhubeka. Nangona ii-analog ze-insulin ezintsha kunye neepompo zanamhlanje ziqhelekile kumazwe anengeniso ephezulu, amazwe amaninzi anengeniso ephantsi nephakathi asasokola ukufikelela nakwi-insulin esisiseko yabantu. Ngokutsho kwe-World Health Organisation, malunga nesiqingatha sabo bonke abantu abafuna i-insulin kwihlabathi liphela abakwazi ukuyifumana okanye ukuyithenga. Ixabiso eliphezulu—ingakumbi kumazwe afana ne-United States—likhokelele ekulinganisweni kwe-insulin, nto leyo enemiphumo emibi.

Imizamo yokuvala esi sikhewu iyaqhubeka. Imibutho engenzi nzuzo efana neLife for a Child kunye nabavelisi be-insulin bayandisa iinkqubo zokunikela. Ii-biosimilars ze-insulin eziqhelekileyo zingena kwiimarike, zibonelela ngezinye iindlela ezingabizi kakhulu.

Njengoko abaphandi behlola ii-insulin ezisebenza ixesha elide, iindlela ezikrelekrele zokuphendula i-glucose, kwanokufakelwa kweeseli ze-beta ezifakwe ngaphakathi, ikamva lithembisa. Kodwa ngaphandle kokufikelela ngokulinganayo, ummangaliso we-insulin uhlala ungafikeleleki kwabaninzi. Usuku lweSifo seswekile lweHlabathi, olugujwa minyaka le ngoNovemba 14, luyaqhubeka nokunyanzelisa "i-Insulin kubo Bonke" - injongo engxamisekileyo namhlanje njengoko yayinjalo kwiminyaka eli-105 eyadlulayo.

Thina basen medical sinayoIkhithi yovavanyo olukhawulezayo lwe-insulinukufunyaniswa kwesifo seswekile kwangethuba. Wamkelekile kumbuzo!