Interleukin-6 (IL-6) tau ua kom nws txoj haujlwm ruaj khov ua ib qho ntawm cov cim qhia tseem ceeb tshaj plaws hauv kev kuaj mob niaj hnub no. Ua ib qho cytokine tseem ceeb hauv cov kab mob inflammatory cascade, kev kuaj IL-6 tau ua pov thawj tias tseem ceeb rau kev kuaj pom thaum ntxov, kev kwv yees, thiab kev tswj hwm ntau yam mob uas hem txoj sia.

Ib Lub Txheej Txheem Ceeb Toom Thaum Ntxov Tseem Ceeb

Tsis zoo li lwm cov cim qhia txog kev mob xws li C-reactive protein (CRP) thiab procalcitonin (PCT), uas nce tom qab thaum muaj kev kis kab mob, IL-6 pib nce sai sai hauv ob teev tom qab muaj kev mob. Qhov no ua rau nws yog lub cim ceeb toom thaum ntxov uas tsis muaj qhov sib piv rau kev mob hnyav uas cuam tshuam nrog kev kis kab mob, kev raug mob, thiab sepsis. Cov kev tshawb fawb tau qhia tias cov neeg mob uas tsis muaj sia nyob hauv kev mob hnyav feem ntau muaj IL-6 ntau dua piv rau cov neeg uas muaj sia nyob, lees paub nws qhov txiaj ntsig kwv yees. Hauv sepsis, IL-6 qib sib raug zoo nrog qhov hnyav ntawm kev ua haujlwm tsis zoo ntawm lub cev, ua rau nws yog ib qho tseem ceeb hauv kev soj ntsuam cov neeg mob uas muaj Systemic Inflammatory Response Syndrome (SIRS).

Kev Kho Mob Qhia Hauv Cov Xwm Txheej Muaj Kev Pheej Hmoo Siab

Qhov kev siv tau ntawm kev kuaj IL-6 hauv kev kho mob nthuav dav tshaj qhov kev kuaj mob xwb; nws yog ib qho cuab yeej muaj zog rau kev coj kev kho mob. Hauv cov ntsiab lus ntawm kev kho mob CAR T-cell, kev kho mob rau qee yam mob qog noj ntshav, IL-6 yog tus neeg sawv cev tseem ceeb ntawm Cytokine Release Syndrome (CRS) - qhov tshwm sim uas tuaj yeem ua rau tuag taus. Cov lus qhia pom zoo kom kuaj IL-6 rau cov neeg mob uas muaj kub taub hau thiab hypotension tom qab kev kho mob CAR T-cell. Qhov tseem ceeb, qhov concentration IL-6 ntau tshaj 2000 pg / mL qhia txog qhov xwm txheej o hnyav thiab xav tau kev cuam tshuam tam sim ntawd nrog cov tshuaj xws li tocilizumab, ib qho IL-6 receptor blocker.

Kev nthuav dav ntawm Kev Siv Kho Mob

Qhov tseem ceeb ntawm kev kuaj IL-6 tab tom nthuav dav thoob plaws ntau qhov chaw kho mob. Nws yog siv los txheeb xyuas cov kev mob hnyav hauv cov neeg mob COVID-19, pab txiav txim siab qhov kev pheej hmoo ntawm kev siv tshuab ua pa. Ntxiv mus, thaum feem ntau siv ua qhov ntsuas tus kheej, kev tshawb fawb qhia tau hais tias kev sib xyaw ua ke ntawm IL-6 qib nrog lwm yam kev pheej hmoo xws li cov qhab nia ua haujlwm tsis zoo ntawm lub cev (SOFA) txhim kho qhov tseeb ntawm kev kwv yees kev tuag ntawm tus neeg mob.

Xaus lus

Txawm hais tias IL-6 yog ib qho cim qhia txog kev o thiab yuav tsum tau txhais hauv cov ntsiab lus kho mob ntawm tus neeg mob, nws lub luag haujlwm ua qhov qhia thaum ntxov thiab txiav txim siab txog qhov hnyav yog qhov tsis lees paub. Thaum cov thev naus laus zis kuaj mob nce qib thiab cov lus qhia hloov pauv, IL-6 tab tom dhau los ua ib feem tseem ceeb ntawm cov cuab yeej kuaj mob, ua rau cov kws kho mob ua haujlwm sai dua thiab zoo dua los cawm txoj sia hauv cov chaw kho mob hnyav.