Interleukin-6 (IL-6) yasimbisa chinzvimbo chayo seimwe yezviratidzo zvakakosha mukuongorora kwekiriniki kwemazuva ano. Senzira huru yekuongorora IL-6, kuongororwa kwechirwere ichi kuri kuratidza kukosha pakuona nekukurumidza, kufungidzira, uye kutarisira zvirwere zvakasiyana-siyana zvinogona kutyisidzira hupenyu.

Sisitimu Yekunyevera Yekutanga Yambiro Yakakosha

Kusiyana nezvimwe zviratidzo zvekuzvimba zvakaita seC-reactive protein (CRP) uye procalcitonin (PCT), izvo zvinokwira gare gare panguva yehutachiona, mazinga eIL-6 anotanga kukwira nekukurumidza mukati memaawa maviri echiitiko chekuzvimba. Izvi zvinoita kuti ive chiratidzo chekutanga chisingaenzaniswi chekuzvimba kwakanyanya kunokonzerwa nehutachiona, kukuvara, uye sepsis. Zvidzidzo zvakaratidza kuti varwere vasingararame kurwara kwakanyanya vanowanzova nemazinga eIL-6 akakwira zvakanyanya kana tichienzanisa nevaya vakapona, zvichiratidza kukosha kwayo kwekufanotaura. Muhutachiona, mazinga eIL-6 anoenderana nekuoma kwekushanda kwenhengo, zvichiita kuti ive chinhu chakakosha mukuongorora varwere vane Systemic Inflammatory Response Syndrome (SIRS).

Kutungamira Kurapa Muzviitiko Zvine Dambudziko Rakanyanya

Kubatsira kwekuyedzwa kweIL-6 kunodarika kungoongororwa chete; chishandiso chine simba chekutungamira kurapwa. Mukurapa kweCAR T-cell, kurapa mamwe magomarara, IL-6 inyanzvi yeCytokine Release Syndrome (CRS)—mhedzisiro inogona kuuraya. Mitemo inokurudzira kuyedzwa kweIL-6 kune varwere vane fivha uye BP mushure mekurapwa neCAR T-cell. Zvakakosha kuti huwandu hweIL-6 hunodarika 2000 pg/mL hunoratidza kuzvimba kwakanyanya uye hunoda kupindira nekukurumidza nemishonga yakaita setocilizumab, IL-6 receptor blocker.

Kuwedzera Maitiro Ekurapa

Kukosha kwekuongororwa kweIL-6 kuri kuwedzera munzvimbo dzakasiyana dzekurapa. Inoshandiswa kuona maitiro ekuzvimba zvakanyanya muvarwere veCOVID-19, zvichibatsira kuona njodzi yekufema kwemuchina. Uyezve, kunyangwe ichiwanzo shandiswa sechiratidzo chega, tsvakiridzo inoratidza kuti kusanganisa mazinga eIL-6 nezvimwe zvinhu zvine njodzi zvakaita se organ failure scores (SOFA) kunovandudza zvakanyanya kururama kwekufanotaura kufa kwevarwere.

Mhedziso

Kunyange hazvo IL-6 iri chiratidzo chisina kujeka chekuzvimba uye ichifanirwa kutsanangurwa mukati mehutano hwese hwemurwere, basa rayo sechiratidzo chekutanga uye chakakosha chekuoma kwechirwere harirambike. Sezvo tekinoroji yekuedza ichifambira mberi uye nhungamiro dzichichinja, IL-6 iri kuva chikamu chakakosha chezvishandiso zvekuongorora chirwere, zvichiita kuti vanachiremba vashande nekukurumidza uye zvinobudirira kuponesa hupenyu munzvimbo dzevarwere vakakomba.