I-Interleukin-6 (IL-6) iqinise isikhundla sayo njengenye yezimpawu ezibaluleke kakhulu ekuxilongweni kwemitholampilo yesimanje. Njenge-cytokine ebalulekile ekwehleni kokuvuvukala, ukuhlolwa kwe-IL-6 kubonakala kubalulekile ekutholakaleni kusenesikhathi, ukubikezela, kanye nokuphathwa kwezimo ezahlukahlukene ezisongela ukuphila.

Uhlelo Olubalulekile Lwesexwayiso Kusenesikhathi

Ngokungafani nezinye izimpawu zokuvuvukala njenge-C-reactive protein (CRP) kanye ne-procalcitonin (PCT), ezikhuphuka kamuva ngesikhathi sokutheleleka, amazinga e-IL-6 aqala ukukhuphuka ngokushesha zingakapheli amahora amabili ngemuva kwesigameko sokuvuvukala. Lokhu kwenza kube uphawu lwe-alamu yokuqala olungenakuqhathaniswa lokuvuvukala okukhulu okuhambisana nokutheleleka, ukulimala, kanye ne-sepsis. Izifundo zibonise ukuthi iziguli ezingasindi ezifweni ezibucayi zivame ukuba namazinga aphezulu e-IL-6 uma kuqhathaniswa nabasindile, okuqinisekisa inani layo lokubikezela. Ku-sepsis, amazinga e-IL-6 ahlobene nobunzima bokungasebenzi kahle kwezitho zomzimba, okwenza kube yingxenye ebalulekile ekuhloleni iziguli ezine-Systemic Inflammatory Response Syndrome (SIRS).

Ukwelashwa Okuqondisayo Ezimweni Ezinzima Kakhulu

Ukusetshenziswa kwezokwelapha kokuhlolwa kwe-IL-6 kudlulela ngale nje kokuxilongwa; kuyithuluzi elinamandla lokuqondisa ukwelashwa. Ngokwesimo sokwelashwa kwe-CAR T-cell, ukwelashwa komdlavuza othile, i-IL-6 ingumlamuleli oyinhloko we-Cytokine Release Syndrome (CRS)—umphumela ongase ube yingozi. Iziqondiso zincoma ukuhlolwa kwe-IL-6 kweziguli ezivezwa umkhuhlane kanye nokwehla kwamandla omzimba ngemva kokwelashwa kwe-CAR T-cell. Okuphawulekayo ukuthi ukuhlushwa kwe-IL-6 okungaphezu kuka-2000 pg/mL kubonisa isimo sokuvuvukala okukhulu futhi kudinga ukungenelela okusheshayo ngemithi efana ne-tocilizumab, i-IL-6 receptor blocker.

Ukwandisa Izicelo Zemitholampilo

Ukubaluleka kokuhlolwa kwe-IL-6 kuyanda emikhakheni eminingi yezokwelapha. Kusetshenziselwa ukuhlonza izimpendulo ezinzima zokuvuvukala ezigulini ze-COVID-19, okusiza ekunqumeni ingozi yokuphefumula ngomshini. Ngaphezu kwalokho, yize kuvame ukusetshenziswa njengesibonakaliso esizimele, ucwaningo lubonisa ukuthi ukuhlanganisa amazinga e-IL-6 nezinye izici eziyingozi njengezikolo zokwehluleka kwezitho (i-SOFA) kuthuthukisa kakhulu ukunemba kokubikezela ukufa kwesiguli.

Isiphetho

Nakuba i-IL-6 iwuphawu olungacacile lokuvuvukala futhi kumele ihunyushwe ngaphakathi komongo ogcwele wezokwelapha wesiguli, indima yayo njengesibonakaliso sokuqala nesinqumayo sobunzima ayinakuphikwa. Njengoba ubuchwepheshe bokuhlola buthuthuka futhi buqhubeka, i-IL-6 iba yingxenye ebalulekile yamathuluzi okuxilonga, okwenza odokotela bakwazi ukwenza ngokushesha nangokuphumelelayo ukusindisa izimpilo ezindaweni zokunakekelwa okubucayi.