I-Interleukin-6 (IL-6) iqinise isikhundla sayo njengenye yezona biomarkers zibalulekileyo kuxilongo lwezonyango lwanamhlanje. Njenge-cytokine ephambili kwi-inflammatory cascade, uvavanyo lwe-IL-6 lubonakala lubalulekile ekufumaneni kwangethuba, ukuxela kwangaphambili, kunye nokulawula uluhlu lweemeko ezisongela ubomi.

Inkqubo Yesilumkiso Esibalulekileyo Kwangethuba

Ngokungafaniyo nezinye iimpawu zokudumba ezifana ne-C-reactive protein (CRP) kunye ne-procalcitonin (PCT), ezinyuka kamva ngexesha losulelo, amanqanaba e-IL-6 aqala ukunyuka ngokukhawuleza kwiiyure ezimbini emva kwesiganeko sokudumba. Oku kwenza ukuba ibe sisilumkiso sokuqala esingenakuthelekiswa nanto sokudumba okukhawulezileyo okunxulunyaniswa nosulelo, ukwenzakala, kunye ne-sepsis. Izifundo zibonise ukuba izigulana ezingasindiyo kwisifo esibalulekileyo zihlala zibonakala zinamanqanaba aphezulu e-IL-6 xa kuthelekiswa nabasindileyo, nto leyo eqinisekisa ixabiso layo lokuxela kwangaphambili. Kwi-sepsis, amanqanaba e-IL-6 ahambelana nobunzima bokungasebenzi kakuhle kwamalungu omzimba, nto leyo eyenza ukuba ibe yinxalenye ebalulekileyo yokuvavanya izigulana ezineSystemic Inflammatory Response Syndrome (SIRS).

Unyango Olukhokelayo Kwiimeko Ezinzima Kakhulu

Ukusetyenziswa kweklinikhi kovavanyo lwe-IL-6 kudlulela ngaphaya kokuxilongwa nje; sisixhobo esinamandla sokukhokela unyango. Kwimeko yonyango lwe-CAR T-cell, unyango lweentlobo ezithile zomhlaza, i-IL-6 ngumlamli ophambili we-Cytokine Release Syndrome (CRS)—isiphumo esibi esinokubangela ukufa. Izikhokelo zicebisa uvavanyo lwe-IL-6 kwizigulana ezibonisa umkhuhlane kunye noxinzelelo lwegazi emva konyango lwe-CAR T-cell. Okubalulekileyo kukuba, uxinano lwe-IL-6 oludlula i-2000 pg/mL lubonisa imeko yokuvuvukala okukhulu kwaye kufuna ukungenelela ngokukhawuleza ngamayeza afana ne-tocilizumab, i-IL-6 receptor blocker.

Ukwandisa Izicelo Zeklinikhi

Ukubaluleka kovavanyo lwe-IL-6 kuyanda kwiindawo ezininzi zonyango. Isetyenziselwa ukuchonga iimpendulo ezinzulu zokudumba kwizigulana ze-COVID-19, nto leyo enceda ekuchongeni umngcipheko womoya ophuma ngoomatshini. Ngaphezu koko, nangona isetyenziswa rhoqo njengesalathisi esizimeleyo, uphando lubonisa ukuba ukudibanisa amanqanaba e-IL-6 nezinye izinto ezinobungozi ezifana namanqaku okusilela kwamalungu omzimba (i-SOFA) kuphucula kakhulu ukuchaneka kokuqikelela ukufa kwesigulana.

Isiphelo

Nangona i-IL-6 iluphawu olungabonakaliyo lokudumba kwaye kufuneka itolikwe ngaphakathi komxholo opheleleyo wezonyango wesigulana, indima yayo njengophawu lokuqala nolugqibeleleyo lobunzima ayinakuphikiswa. Njengoko ubuchwepheshe bokuvavanya buqhubeka kunye nezikhokelo zitshintsha, i-IL-6 iba yinxalenye ebalulekileyo yesixhobo sokuxilonga, esenza ukuba oogqirha basebenze ngokukhawuleza nangokufanelekileyo ukusindisa ubomi kwiindawo zokhathalelo olubalulekileyo.