Kua whakaukia te tūranga o te Interleukin-6 (IL-6) hei tētahi o ngā tohu koiora tino nui i roto i ngā tātaritanga haumanu hou. Hei cytokine matua i roto i te rerenga mumura, he mea nui te whakamātautau IL-6 mō te kitenga wawe, te matapae, me te whakahaere i ngā momo mate e morearea ana ki te ora.

He Pūnaha Whakatūpato Moata Tino Hira

He rerekē ki ētahi atu tohu mumura pērā i te pūmua C-reactive (CRP) me te procalcitonin (PCT), e piki ake ana i muri mai i te wā o te mate, ka tīmata te piki tere o ngā taumata IL-6 i roto i ngā haora e rua o te mumura. Nā tēnei ka waiho hei tohu whakaoho wawe kore e rite mō te mumura whakapeka e pā ana ki te mate, te whara, me te sepsis. Kua whakaatuhia e ngā rangahau ko ngā tūroro kāore e ora i te mate kino he maha ngā wā ka puta mai me ngā taumata IL-6 teitei ake i ērā i ora mai, e whakaū ana i tōna uara matapae. I roto i te sepsis, ka hono ngā taumata IL-6 ki te kaha o te ngoikore o ngā okana, ka waiho hei wāhanga nui i roto i te aromatawai i ngā tūroro e pāngia ana e te Systemic Inflammatory Response Syndrome (SIRS).

Te Maimoatanga Ārahi i roto i ngā Horopaki Tino Taumaha

Ko te whai huatanga haumanu o te whakamātautau IL-6 kei tua atu i te tātaritanga noa iho; he taputapu kaha hei ārahi i te maimoatanga. I roto i te horopaki o te rongoā pūtau-T CAR, he maimoatanga mō ētahi mate pukupuku, ko te IL-6 te takawaenga matua o te Cytokine Release Syndrome (CRS)—he pānga taha ka mate pea. E taunaki ana ngā aratohu i te whakamātautau IL-6 mō ngā tūroro e pāngia ana e te kirika me te toto toto iti i muri i te rongoā pūtau-T CAR. He mea nui, ko te kukū IL-6 e neke ake ana i te 2000 pg/mL he tohu i te āhua mumura nui, ā, me wawao tonu ki ngā rongoā pēnei i te tocilizumab, he aukati i te kaiwhiwhi IL-6.

Te Whanui i ngā Whakamahinga Hauora

Kei te whānui haere te hiranga o te whakamātautau IL-6 puta noa i ngā mara hauora maha. Ka whakamahia hei tautuhi i ngā urupare mumura kino i roto i ngā tūroro COVID-19, hei āwhina i te whakatau i te mōrearea o te manawa miihini. Hei tāpiri, ahakoa e whakamahia ana hei tohu takitahi, e whakaatu ana ngā rangahau ko te whakakotahi i ngā taumata IL-6 me ētahi atu āhuatanga mōrearea pēnei i ngā kaute ngoikore o te okana (SOFA) ka tino whakapai ake i te tika o te matapae i te matenga o te tūroro.

Whakamutunga

Ahakoa he tohu kore-motuhake te IL-6 mō te mumura, me whakamārama i roto i te horopaki haumanu katoa o te tūroro, kāore e taea te whakakorekore i tōna tūranga hei tohu wawe me te whakatau mō te kaha o te mate. I te whanaketanga haere o te hangarau whakamātautau me ngā aratohu, kei te noho te IL-6 hei wāhanga nui o te kete taputapu tātaritanga, e āhei ai ngā tākuta ki te mahi tere ake me te whai hua ake ki te whakaora i ngā oranga i roto i ngā wāhi tiaki nui.