Chida chodziwitsira matenda chomwe chavomerezedwa kumene cha puloteni yomangira heparin (HBP) chikupatsa madokotala njira yachangu yodziwira matenda a bakiteriya ndi sepsis, vuto lomwe ola lililonse la chithandizo chochedwa limawonjezera chiopsezo cha imfa. Chidachi, chomwe chimagwiritsa ntchito fluorescence immunochromatography, chavomerezedwa m'malo osiyanasiyana ngati chipangizo chodziwitsira matenda cha Class II in vitro.

HBP ndi puloteni yomwe imasungidwa mu ma neutrophils ndipo imatulutsidwa mkati mwa ola limodzi kapena awiri kuchokera pamene kachilombo ka bakiteriya kamafalikira. Mosiyana ndi zizindikiro zachikhalidwe monga procalcitonin kapena puloteni ya C-reactive, HBP imatuluka msanga kwambiri ndipo imagwirizana makamaka ndi matenda a bakiteriya—osati a kachilombo—koyambitsa matenda. Kutulutsa mwachangu kumeneku kumapatsa madokotala mwayi wofunikira wosiyanitsa matenda a bakiteriya ndi matenda ena otupa.

Deta ya momwe zinthu zilili pachipatala ikuthandizira kufunika kwa matenda a kit. Kafukufuku wa 2025 wofalitsidwa mu *Scientific Reports* wowunikira HBP kuti adziwe bacteremia mwa odwala omwe ali ndi sepsis adapeza kuti ali ndi mphamvu ya 88.64% komanso 68.06% pamlingo wa 95.69 ng/mL. Mtengo woyerekeza woipa unafika pa 89.71%, zomwe zikusonyeza kuti mayesowa ndi othandiza kwambiri poletsa matenda a m'magazi. Mu kafukufukuyu, odwala omwe ali ndi bacteremia anali ndi milingo yapakati ya HBP ya 204.13 ng/mL poyerekeza ndi 81.43 ng/mL m'mabotolo.

Malangizo aku China okhudza Kusamalira Sepsis Yaikulu ndi Septic Shock azindikira kale HBP ngati chizindikiro choyambirira chodziwira matenda. Kafukufuku akusonyeza kuti kuchuluka kwa HBP kumayenderana ndi kuopsa kwa matenda—kukwera pang'onopang'ono kuchoka pa sepsis yosavuta kupita ku septic shock—ndipo kumachepa msanga maantibayotiki akagwira ntchito bwino, zomwe zimapangitsa kuti ikhale yothandiza poyang'anira momwe chithandizo chimayankhidwira.

Kuyesaku kumafuna plasma yochepa kapena chitsanzo cha magazi athunthu ndipo kumapereka zotsatira zochulukirapo mu mphindi pafupifupi 15, zomwe zimagwirizana ndi njira yoyesera malo osamalira odwala yomwe imafunika m'madipatimenti odzidzimutsa ndi m'mayunitsi osamalira odwala kwambiri. Chidachi chimagwira ntchito ndi chowunikira cha fluorescence immunoassay chogwirizana ndipo chili ndi khadi la IC loyezera.

Madokotala ayenera kutanthauzira zotsatira pamodzi ndi zomwe zapezeka kuchipatala komanso mayeso ena a labotale, chifukwa kuchuluka kwa HBP kumatha kuchitikanso m'malo otupa omwe si opatsirana. Komabe, kayendedwe kake kachangu komanso kudziwika bwino kwa mabakiteriya kumaika HBP ngati chowonjezera chofunikira pa chida chodziwira matenda a sepsis, komwe kuzindikira koyambirira kumakhalabe chinthu chofunikira kwambiri chomwe chimapangitsa kuti munthu apulumuke.