Ikhithi yokuxilonga esanda kuvunyelwa yeprotheyini ebopha i-heparin (i-HBP) inikeza odokotela indlela esheshayo yokuhlonza ukutheleleka kwamagciwane kanye ne-sepsis, isimo lapho ihora ngalinye lokwelashwa okulibazisekile landisa kakhulu ingozi yokufa. Le khithi, esebenzisa i-fluorescence immunochromatography, ithole imvume yokulawula ezindaweni eziningi njengedivayisi yokuxilonga ye-Class II in vitro.

I-HBP iyiprotheni egcinwe kuma-neutrophils futhi ikhishwa zingakapheli ihora elilodwa kuya kwamabili ngemuva kokutheleleka ngamagciwane. Ngokungafani nezimpawu zendabuko ezifana ne-procalcitonin noma iphrotheni ephendulayo ye-C, i-HBP ikhuphuka kusenesikhathi futhi ihlobene ngqo nokutheleleka ngamagciwane—kunokuba ngamagciwane. Lokhu kukhishwa okusheshayo kwe-kinetics kunikeza odokotela ithuba lokuqala elibalulekile lokuhlukanisa i-bacterial sepsis kwezinye izimo zokuvuvukala.

Idatha yokusebenza kwemitholampilo isekela inani lokuxilonga lekhithi. Ucwaningo lwango-2025 olwanyatheliswa ku-*Scientific Reports* oluhlola i-HBP ukuze lubone i-bacteremia ezigulini ezine-sepsis luthole ukuzwela okungu-88.64% kanye nokucaciswa okungu-68.06% ekunqunyweni okungu-95.69 ng/mL. Inani elibi lokubikezela lifinyelele ku-89.71%, okuphakamisa ukuthi ukuhlolwa kuwusizo kakhulu ekuvimbeleni ukutheleleka kwegazi. Ocwaningweni, iziguli ezine-bacteremia zazinamazinga aphakathi e-HBP angu-204.13 ng/mL uma kuqhathaniswa no-81.43 ng/mL ezilawulwayo.

Iziqondiso zaseShayina Zokuphathwa Kwe-Severe Sepsis kanye ne-Septic Shock sezivele ziqaphele i-HBP njengesibonakaliso sokuqala sokuxilonga. Ucwaningo lubonisa ukuthi amazinga e-HBP alandela ubunzima besifo—enyuka kancane kancane kusukela ku-sepsis elula kuya ku-septic shock—futhi ehla ngokushesha lapho ama-antibiotic esebenza kahle, okwenza kube usizo ekuqapheni impendulo yokwelashwa.

Ukuhlolwa kudinga isampula encane yegazi noma isampula yegazi eliphelele futhi kunikeza imiphumela yobuningi cishe ngemizuzu eyi-15, kufaka imodeli yokuhlola indawo yokunakekelwa edingekayo eminyangweni yezimo eziphuthumayo kanye namayunithi okunakekelwa okujulile. Ikhithi isebenza nge-fluorescence immunoassay analyzer ehambisanayo futhi ifaka ikhadi le-IC lokulinganisa.

Odokotela kufanele bahumushe imiphumela kanye nokutholakele kwezokwelapha kanye nezinye izivivinyo zelebhu, njengoba ukuphakama kwe-HBP kungenzeka nasezimweni zokuvuvukala ezingathelelani. Noma kunjalo, ukuhamba kwayo okusheshayo kanye nokucaciswa kwamagciwane kubeka i-HBP njengesengezo esibalulekile kuthuluzi lokuxilonga i-sepsis, lapho ukuqashelwa kusenesikhathi kuhlala kuyisici esibaluleke kakhulu sokusinda.