Kei te tukuna e tētahi kete tātaritanga hou kua whakaaetia mō te pūmua here-heparin (HBP) he ara tere ake ki ngā tākuta hei tautuhi i ngā mate kitakita me te sepsis, he āhuatanga e whakanuia ai te mōrearea mate i ia haora o te maimoatanga whakaroa. Kua whiwhi te kete, e whakamahi ana i te immunochromatography fluorescence, i te whakaaetanga ture i roto i ngā mana whakahaere maha hei taputapu tātaritanga in vitro Akomanga II.

He pūmua te HBP e rongoatia ana i roto i ngā neutrophils ka tukuna i roto i te kotahi ki te rua hāora i muri i te pangia e te huakita. He rerekē ki ngā tohu tuku iho pērā i te procalcitonin, te pūmua C-reactive rānei, ka piki wawe te HBP, ā, ka hono atu ki ngā mate huakita—kaua ki ngā mate huaketo. Mā tēnei tere tukunga ka taea e ngā tākuta te tīmata wawe ki te wehewehe i te sepsis huakita mai i ētahi atu mate mumura.

E tautoko ana ngā raraunga mahi haumanu i te uara tātaritanga o te kete. I roto i tētahi rangahau i whakaputaina i te tau 2025 i roto i *Scientific Reports* e aromatawai ana i te HBP mō te tautuhi i te bacteremia i roto i ngā tūroro sepsis, i kitea he 88.64% te aro me te 68.06% te motuhaketanga i te taumata tapahi o te 95.69 ng/mL. I eke te uara matapae kino ki te 89.71%, e kī ana he tino whai hua te whakamātautau mō te whakakore i ngā mate toto. I roto i te rangahau, ko te toharite o ngā taumata HBP o ngā tūroro bacteremia he 204.13 ng/mL, ki te whakaritea ki te 81.43 ng/mL i roto i ngā mana whakahaere.

Kua mōhio kē ngā Aratohu Hainamana mō te Whakahaere i te Sepsis Nui me te Septic Shock ki te HBP hei tohu tātaritanga wawe. E whakaatu ana ngā rangahau ka whai ngā taumata HBP i te kaha o te mate—ka piki haere mai i te sepsis kore uaua ki te septic shock—ā, ka heke tere ina whai hua ngā paturopi, ā, he mea whai hua mō te aroturuki i te urupare maimoatanga.

He iti noa te tauira toto toto, toto katoa rānei e hiahiatia ana mō te whakamātautau, ā, ka puta ngā hua tau i roto i te 15 meneti pea, e rite ana ki te tauira whakamātautau i ngā wāhi tiaki e hiahiatia ana i roto i ngā tari ohorere me ngā wāhanga tiaki nui. Ka mahi tahi te kete me tētahi tātaritanga whakamātautau ārai mate fluorescence hototahi, ā, kei roto hoki he kāri IC mō te whakatikatika.

Me whakamārama ngā tākuta i ngā hua me ngā kitenga haumanu me ētahi atu whakamātautau taiwhanga, nā te mea ka taea hoki te pikinga o te HBP i roto i ngā āhua mumura kāore i te pangia. Ahakoa rā, nā te tere o te nekeneke me te motuhaketanga o te huakita, ka waiho te HBP hei tāpiri nui ki te taputapu tātaritanga mō te sepsis, ā, ko te kitenga wawe tonu te mea tino nui hei whakatau i te oranga.