Kiti itsva yekuongorora chirwere cheHeparin-binding protein (HBP) iri kupa vanachiremba nzira yekukurumidza yekuziva hutachiona hwebhakitiriya uye sepsis, chirwere apo awa yega yega yekurapwa kwakanonoka inowedzera zvakanyanya njodzi yekufa. Kiti iyi, inoshandisa fluorescence immunochromatography, yakapihwa mvumo yepamutemo munzvimbo dzakasiyana siyana sechishandiso cheClass II chekuongorora chirwere chemuviri.

HBP ipuroteni inochengetwa muma neutrophils uye inoburitswa mukati meawa imwe kusvika maviri mushure mehutachiona hwebhakitiriya. Kusiyana nezviratidzo zvechinyakare zvakaita seprocalcitonin kana C-reactive protein, HBP inomuka nekukurumidza uye inoenderana zvakanyanya nehutachiona hwebhakitiriya - pane hwehutachiona. Iyi kinetics yekubuda nekukurumidza inopa vanachiremba mukana wekutanga wakakosha mukusiyanisa hutachiona hwebhakitiriya kubva kune mamwe mamiriro ekuzvimba.

Ruzivo rwekushanda kwekiriniki runotsigira kukosha kwekuongorora kwekit. Chidzidzo cha2025 chakaburitswa mu *Scientific Reports* chakaongorora HBP kuti chionekwe hutachiona hwemabhakitiriya muvarwere vane sepsis chakawana kunzwisiswa kwe88.64% uye 68.06% pamucheto we95.69 ng/mL. Kukosha kwekufanotaura kwakashata kwakasvika 89.71%, zvichiratidza kuti bvunzo iyi inobatsira zvikuru pakubvisa hutachiona hweropa. Muchidzidzo ichi, varwere vane bacteremia vaive neavhareji yemazinga eHBP e204.13 ng/mL zvichienzaniswa ne81.43 ng/mL muvanhu vanodzora.

Nhungamiro dzeChinese dzeKutarisira Sepsis Yakakomba neSeptic Shock dzakatoona HBP sechiratidzo chekutanga chekuongorora chirwere. Tsvagiridzo inoratidza kuti huwandu hweHBP hunotevedzana nekuoma kwechirwere—huchikwira zvishoma nezvishoma kubva pasepsis isina kuoma kusvika paseptic shock—uye huchidzikira nekukurumidza kana mishonga inorwisa mabhakitiriya ichishanda, zvichiita kuti ibatsire pakutarisa mhinduro dzekurapa.

Kuongororwa uku kunoda plasma diki kana kuti ropa rose uye kunopa mhedzisiro yakawanda mumaminitsi angangoita gumi nemashanu, zvichiisa modhi yekuyedza yenzvimbo yekutarisira inodiwa mumadhipatimendi ekukurumidzira nemayuniti ekutarisira varwere zvakanyanya. Kit iyi inoshanda ne fluorescence immunoassay analyzer inoenderana uye inosanganisira kadhi reIC rekuyedza.

Vanachiremba vanofanira kududzira mhedzisiro pamwe chete nezvakawanikwa mukiriniki uye mimwe miedzo yemurabhoritari, sezvo kuwedzera kweHBP kunogonawo kuitika mune dzimwe nzvimbo dzisina hutachiona. Kunyange zvakadaro, kinetics yayo nekukurumidza uye hunyanzvi hwebhakitiriya zvinoisa HBP sechinhu chakakosha chekuwedzera kune chishandiso chekuongorora chirwere che sepsis, uko kuzivikanwa kwekutanga kunoramba kuri chinhu chinonyanya kukosha pakurarama.