Ikhithi yokuxilonga esandula ukuvunywa yeproteni ebopha i-heparin (i-HBP) inika oogqirha indlela ekhawulezayo yokuchonga usulelo lweebhaktheriya kunye ne-sepsis, imeko apho iyure nganye yonyango olulibazisekileyo inyusa kakhulu umngcipheko wokufa. Le khithi, esebenzisa i-fluorescence immunochromatography, ifumene imvume yomthetho kwiindawo ezahlukeneyo njengesixhobo sokuxilonga seKlasi yesiBini kwi-vitro.

I-HBP yiproteni egcinwe kwi-neutrophils kwaye ikhutshwa kwiyure enye ukuya kwezimbini emva kosulelo lwebhaktiriya. Ngokungafaniyo neempawu zemveli ezifana ne-procalcitonin okanye i-C-reactive protein, i-HBP iphakama kwangoko kwaye ihambelana ngokukodwa nosulelo lwebhaktiriya—kunokuba yintsholongwane. Olu tshintsho lwe-kinetics olukhawulezileyo lunika oogqirha ithuba lokuqala elibalulekileyo lokwahlula i-bacterial sepsis kwezinye iimeko zokudumba.

Idatha yokusebenza kweklinikhi ixhasa ixabiso lokuxilonga le khithi. Uphononongo luka-2025 olupapashwe kwi *Scientific Reports* oluvavanya i-HBP yokuchonga i-bacteremia kwizigulane ezine-sepsis lufumene uvakalelo lwe-88.64% kunye nokuchaneka kwe-68.06% kumgca we-95.69 ng/mL. Ixabiso elibi lokuqikelela lifikelele kwi-89.71%, nto leyo ebonisa ukuba uvavanyo luluncedo kakhulu ekuthinteleni usulelo lwegazi. Kolu phononongo, izigulane ezine-bacteremia zazinamanqanaba aphakathi e-HBP angama-204.13 ng/mL xa kuthelekiswa ne-81.43 ng/mL kulawulo.

Izikhokelo zaseTshayina zoLawulo lweSepsis Enzima kunye neSeptic Shock sele ziyiqaphele i-HBP njengophawu lokuqala lokuxilonga. Uphando lubonisa ukuba amanqanaba e-HBP alandelelana nobunzima besifo—enyuka ngokuthe ngcembe ukusuka kwi-sepsis engantsonkothanga ukuya kwi-septic shock—kwaye ehla ngokukhawuleza xa ii-antibiotics zisebenza kakuhle, nto leyo eyenza ukuba ibe luncedo ekujongeni impendulo yonyango.

Olu vavanyo lufuna isampuli encinci yegazi okanye igazi elipheleleyo kwaye lunika iziphumo zobungakanani malunga nemizuzu eli-15, lufake imodeli yovavanyo lwendawo yokhathalelo efunekayo kumasebe ongxamiseko nakwiiyunithi zokhathalelo olunzulu. Le khithi isebenza nge-fluorescence immunoassay analyzer ehambelanayo kwaye ibandakanya ikhadi le-IC lokulinganisa.

Oogqirha kufuneka batolike iziphumo kunye neziphumo zeklinikhi kunye nezinye iimvavanyo zelebhu, njengoko ukunyuka kwe-HBP kunokwenzeka nakwiimeko zokudumba ezingasuleliyo. Nangona kunjalo, i-kinetics yayo ekhawulezayo kunye nokucaciswa kwebhaktheriya kubeka i-HBP njengokongeza okuxabisekileyo kwisixhobo sokuxilonga i-sepsis, apho ukuqatshelwa kwangoko kuhlala kuyinto ebaluleke kakhulu ekuqinisekiseni ukusinda.