# Whakamātautau Calprotectin Tūtae: He Huringa Tauira i roto i te Whakahaere Mate Puku

**He Tohu Koiora Kore-Whakaeke e Whakarerekē ana i te Tātaritanga me te Aroturukitanga IBD**

I ngā tau tata nei, kua puta ake te fecal calprotectin (FC) hei tohu matua mō te tohu koiora i roto i te gastroenterology, ā, kua tino whakarerekē i te huarahi e tautuhia ai me te whakahaere i te mate puku mumura (IBD). I te mea kei te whakamahi tonu te hapori hauora i ngā taputapu tātaritanga kore-whakaeke, e tū pakari ana te whakamātautau FC mō tōna whai huatanga haumanu, e tautokona ana e te nui haere o ngā taunakitanga me te whakamanatanga whaimana i roto i ngā aratohu haumanu.

## Te Hiranga Hauora o Calprotectin

Ko te Calprotectin he pūmua here-konupūmā e tukuna ana e ngā neutrophils kua whakahohehia i roto i te kiriuhi puku i te wā mumura. Ina puta te mumura, ka tukuna te calprotectin i roto i ngā paru, ka whakarato i tētahi tohu pumau, ka taea te ine, te tohu pumau hoki mō te mumura o te puku. Nā tōna āhua kore-whakaeke, me te pumau tātari me te pai mō ngā inenga anō, ka waiho hei taputapu tino whai hua i roto i te mahi haumanu hou.

## Te Wehewehe i te IBD mai i te IBS: He Whakamahinga Hauora Tino Hira

Ko tētahi o ngā wero haumanu nui rawa atu i roto i te gastroenterology ko te wehewehe i te IBD—tae atu ki te mate a Crohn me te ulcerative colitis—mai i te irritable bowel syndrome (IBS). E rua ngā āhuatanga e whakaatu ana i ngā tohumate puku taupatupatu, engari ko te IBD he mumura mucosal organic e hiahia ana ki te rongoā ārai mate, ā, he mōrearea hoki mō ngā raruraru. I tetahi atu taha, ko te IBS he mate mahi kāore he pathology organic e taea te tautuhi.

Kua kitea he tino whai hua te whakamātautau calprotectin paru i roto i tēnei tātaritanga rerekē. E whakaatu ana te tohu koiora i te aro o te 95% me te motuhake o te 91% i te taumata tapahi o te 50 μg/g i te wā e wehewehe ana i ngā tūroro IBD mai i ngā mana hauora. Mā tēnei mahi tātaritanga ka taea e ngā tākuta te whakarōpū i ngā tūroro me te tautuhi i te hunga e hiahia ana ki te aromatawai endoscopic me te whakaiti i ngā tikanga whakaeke kore e tika ana mō ngā tūroro he mate mahi. Kua tautokohia e ngā aratohu haumanu 2025 mai i te American College of Gastroenterology he taumata tapahi calprotectin paru mahi o >50–100 mg/g hei wehewehe i te mate mumura mai i te mate kore-mumura.

## Te Aromatawai i ngā Mahi Mate me te Arataki i te Maimoatanga

Haunga te tātaritanga, kua whakaatuhia e te whakamātautau FC te whai huatanga nui ki te aroturuki i ngā mahi a te mate me te aromatawai i te urupare maimoatanga. Kua whakatūria e te rangahau mai i Mayo Clinic he hononga nui, he hononga tauanga i waenga i ngā taumata FC me ngā kaute endoscopic i roto i ngā tūroro ulcerative colitis, e kī ana ka taea e te FC te mahi hei tohu pono, tino tairongo hoki mō te mumura endoscopic. Ina koa, ko te tapahi FC o te 60 mcg/g i wehewehe pai i te murunga endoscopic mai i te mate hohe, i te mea ko ngā paepae teitei ake i tohu i te mumura kino ake.

He nui ngā pānga o ēnei kitenga ki te mahi haumanu. Mā te kaha ki te aroturuki i ngā mahi a te mate mā te whakamātautau tūtae māmā noa iho, kaua mā te tirotiro i te endoscopy anō, ka taea e ngā tākuta te whai hua, te whai hua hoki mō te whakatikatika maimoatanga.

Ka taea e mātou te whakamātautau tere a Baysen te whakarato i te whakamātautau calprotectin me te whakamātautau kounga me te whakamātautau tauanga. Nau mai ki te uiui!