Uhudo olungapheli oluhlala isikhathi esingaphezu kwamasonto amane luyisibonakaliso "esibomvu" esizwakala emathunjini, futhi kudingeka uqaphele isifo samathumbu esivuvukalayo (IBD).

Kodwa nansi inkinga: uma ungena emtholampilo, udokotela unquma kanjani ukuthi amathumbu akho avuvukele ngempela? Futhi ukuvuvukala kukhulu kangakanani? Kuleli qophelo, kuhlolwa okubonakala “kungajwayelekile” kuqala ukusebenza —i-calprotectin yendle ukuhlolwa. Kufana “nomhumushi” othembekile ongahumusha “ukuhleba” kwamathumbu kube idatha odokotela abangayiqonda. Kulolu shicilelo lwe-“Ukwazi Kangakanani Ngesisu,” sizokusiza ukuthi wazi lo “mhumushi” wempilo yamathumbu.

1) Uma amathumbu evuvukele, ubani ongasitshela?

Cabanga ngalokhu: amathumbu akho “ayasha,” kodwa awukwazi ukuwabona noma ukuwathinta — ungaqagela kuphela “ngezimpawu ezingaqondile” ezifana nesifo sohudo kanye nobuhlungu besisu.

Ingabe ikhona indlela engasitshela ngokuqondile nangokungakhethi — ukuthi amathumbu avuvukele yini nhlobo? Futhi ukuthi ukuvuvukala kukhulu kangakanani?

Impendulo ithi: yebo. Futhi ifihliwe khona kanye esitulweni sakho.

Uma kwenzeka ukuvuvukala kwamathumbu, ama-neutrophil aqoqana ngobuningi endaweni yokuvuvukala ukuze “acime umlilo.” Phakathi nale “mpi,” la maseli akhipha iphrotheni —i-calprotectinIkhishwa emzimbeni kanye nendle, futhi ukuhlushwa kwayo kubonisa ngqo ubukhali bokuvuvukala kwamathumbu.

2)I-Calprotectin: Kungani idonsele ukunaka kwezokwelapha?

Ngaphambii-calprotectinkwavela, odokotela bathembele kakhulu ezinkombeni zegazi (njenge-I-CRP, i-ESR, njll.) ukuze kwahlulelwe ukuvuvukala. Kodwa lezi zinkomba "zinephutha elibulalayo" - azinakho ukucaciswa kwamathumbu. Ngamanye amazwi, uma ziphakeme, kungase kubonise ukuvuvukala endaweni ethile emzimbeni, kodwa hhayi ngempela emathunjini.I-Calprotectinkuhlukile. Kunezinzuzo eziningana zemvelo:

Iqiniso elilodwa:i-calprotectin yendle ifakiwe eziqondisweni zaseShayina zokuxilonga nokwelapha isifo samathumbu esivuvukalayo, yaba yi-biomarker evame ukusetshenziswa emtholampilo.

3) Yini lo “mhumushi” angasisiza ukuyenza?

Ukusetshenziswa kwemitholampilo kwei-calprotectin yendle ziya ngokuya zikhula, ikakhulukazi okuhlanganisa izici ezilandelayo:

① Ukuhlukanisa i-IBD ne-IBS

Lokhu “okukhethekile” okukhulu kwe-calprotectin. Izimpawu ze-irritable bowel syndrome (IBS) kanye nesifo samathumbu esivuvukalayo (IBD) ngezinye izikhathi zingafana kakhulu - zombili zingabangela ubuhlungu besisu, uhudo, kanye nezinguquko emikhubeni yamathumbu. Kodwa lokhu okubili kuhluke kakhulu: I-IBS iyisifo esisebenzayo, esingenakho ukuvuvukala okungokwemvelo emathunjini; I-IBD ukuvuvukala kwamathumbu kwangempela.

② Ukuhlola umsebenzi wesifo

Kubantu asebevele betholakale benesifo se-IBD,i-calprotectinUngatshela odokotela: ingabe lesi sifo sisesigabeni esisebenzayo noma sisekuphumuleni? Izifundo zibonisa ukuthi amazinga e-calprotectin endle ahlobene kakhulu nezinga lokuvuvukala kwamathumbu okubonwa ngaphansi kwe-endoscopy. Uma inani liphakeme, ukuvuvukala kuba kubi kakhulu; ukwehla kwenani kungasebenza njengenye yezinkomba zokubhekisela kodokotela zokuhlola ukusebenza kahle kokwelashwa.

③ Ukuqapha ukusebenza kahle nokubikezela ukubuyela emuva kwesifo

I-IBD yisifo esingamahlalakhona esidinga ukuphathwa isikhathi eside.I-Calprotectinkufana “nomlindi.” Ukwehla kwe-calprotectin ngemva kokwelashwa kungabonisa ukuthi ukwelashwa kuyasebenza; uma i-calprotectin iqala ukukhuphuka esigulini lapho sesikhululekile, kungase kubonise ukubuyela emuva okungenzeka, okuvumela odokotela ukuthi balungise uhlelo lokwelashwa kusenesikhathi.

④ Ukuphenya imbangela yokungakhululeki kwamathumbu ezinganeni

Ezinganeni ezincane, ukuhlolwa kwe-calprotectin kubaluleke kakhulu. Kungasiza ukuhlukanisa ubuhlungu besisu obusebenzayo nesifo sangempela sokuvuvukala kwamathumbu, kugweme ukuhlolwa okungadingekile kokuhlasela.

4) Imiphumela yokuhlolwa kufanele ihunyushwe kanjani? Asho ukuthini amanani?

Uma uthola umbiko wokuhlolwa, ungase ubone uchungechunge lwezinombolo. Zisho ukuthini?

5) Ngubani okhuthazwayo ukuba adlulei-calprotectin ukuhlolwa?

Uma wena noma ilungu lomndeni lihlangabezana nalokhu okulandelayo, kunconywa ukuthi nibonisane nodokotela mayelana nokuthi kudingeka yini ukuhlolwa:

• Ubuhlungu besisu noma isifo sohudo esingathuthuki isikhathi esingaphezu kwamasonto amane
• Indle ene-mucus noma ubomvu negazi
• Ukwehla kwesisindo okungachazeki noma i-anemia
• Sekuvele kutholakale ukuthi une-IBD futhi udinga ukuqapha izifo
• Izingane ezinezinhlungu zesisu eziphindaphindayo noma ukukhubazeka kokukhula, ukuze kuqedwe izifo eziphilayo
• Ukuhlolwa okusizayo kwamaqembu asengozini enkulu yomdlavuza we-colorectal