19 ga Mayu ita ce Ranar Duniya ta IBD, wanda aka sadaukar domin wayar da kan jama'a game da cututtukan hanji (IBD) da kuma kula da marasa lafiya da ke fama da cutar IBD. Ciwon hanji na IBD ya fi shafar cututtukan ulcerative colitis (UC) da cutar Crohn (CD). Ciwon hanji ne mai tsanani, wanda ke sake dawowa wanda ke lalata rayuwar marasa lafiya sosai. A wannan karon, muna farin cikin raba wani sabon bincike da Asibitin Union, Kwalejin Kiwon Lafiya ta Tongji, Jami'ar Kimiyya da Fasaha ta Huazhong ta gudanar, wanda ya yi amfani da shi wajen magance cutar.Kit ɗin Gwajin Calprotectin(Yunkurin Gwaji na Immunochromatography na FICA)da kumaMai Nazarin Immunoassay Mai Ci Gaba na WIZ-A202wanda muka haɓaka, yana ba da muhimman nassoshi don kula da cututtuka ga marasa lafiya na UC.
Bayanin Bincike: Neman Ingantattun Alamomin Kulawa Marasa Zafi ga UC
Colonoscopy ita ce "ma'aunin zinare" don tantance ayyukan cututtukan endoscopic a cikin UC, amma yana da haɗari kuma marasa lafiya ba sa jure shi sosai, wanda ke sa kulawa akai-akai ta yi wahala.Sunadarin C-reactive (CRP) da kuma erythrocyte sedimentation rate (ESR) ba su da takamaiman tsari kuma suna da alaƙa da kumburin hanji sosai.
Calprotectin na hanji (FC), wata alama ta kumburi da aka samo daga neutrophils, ta zama muhimmin kayan aiki mara cutarwa a cikin kula da IBD. Duk da haka, iyakokin FC sun bambanta sosai a cikin hanyoyin ganowa daban-daban saboda rashin ƙimar yankewa daidaitacce. Gwajin Fluorescence immunochromatography (FICA) hanya ce mai sauri da sauƙi ta ganowa, amma ƙimar yankewa ta asibiti mafi kyau tana buƙatar ƙarin tabbaci.
Manufofin Bincike da Hanyoyin
1) Manufofin Bincike: Wannan binciken yana da nufin kimanta alaƙar da ke tsakanin FC da FICA ta gano da ayyukan cututtukan asibiti/endoscopic a cikin UC, da kuma tantance mafi kyawun ƙimar yankewa don annabta ayyukan cututtuka.
2) Yawan Jama'a da aka yi nazari a kansu: Marasa lafiya 110 da aka gano suna dauke da cutar UC waɗanda aka kwantar a asibiti a Asibitin Union, Kwalejin Kiwon Lafiya ta Tongji, Jami'ar Kimiyya da Fasaha ta Huazhong tsakanin Janairu 2021 da Yuni 2022.
3) Hanyar Ganowa: An auna FC ta amfani daMai Nazarin Immunoassay Mai Ci Gaba na WIZ-A202 da kuma daidaitoKayan Calprotectin FICAdaga gare mu
4) Ka'idojin Kimantawa: An tantance ayyukan asibiti ta hanyar amfani da ma'aunin Mayo (pMS); an tantance ayyukan endoscopic ta hanyar amfani da Ulcerative Colitis Endoscopic Index of Severity (UCEIS) da Mayo Endoscopic Score (MES).
Sakamakon Bincike Mai Muhimmanci
1. Matakan FC suna da alaƙa sosai da ayyukan cututtuka.
Matakan FC sun nuna alaƙa mai kyau da pMS (r=0.609), UCEIS (r=0.751), da MES (r=0.635) (duk P<0.001), tare da ingantacciyar alaƙa fiye daCRPda kuma ESR. Alaƙa tsakanin FC da aikin endoscopic ya kasance mai ƙarfi musamman.
2. An ƙayyade mafi kyawun ƙimar yankewa.
| Manufar Hasashen | Mafi kyawun yankewa (μg/g) | Sanin hankali | Takamaiman Bayani |
|---|---|---|---|
| Ayyukan asibiti (pMS ≥ 3) | ≥57.38 | 78.02% | 100% |
| Aikin Endoscopic (UCEIS ≥ 1 / MES ≥ 1) | ≥53.30 | 71.57–73.74% | 100% |
3. FC ta nuna kyakkyawan aiki wajen nuna bambanci tsakanin 'yan wasan UC masu aiki.
Binciken lanƙwasa na ROC ya nuna cewa AUC na FC don annabta ayyukan asibiti shine 0.9456, kuma don annabta ayyukan endoscopic shine 0.9075 (UCEIS) da 0.9118 (MES), duk sun fi CRP da ESR girma sosai.
4. Gyaran asibiti ba daidai yake da gyara endoscopic ba.
Daga cikin marasa lafiya 11 da suka sami sassaucin asibiti (pMS < 3) amma har yanzu suna da aikin endoscopic, 10 (90.91%) suna da matakan FC ƙasa da 53.30 μg/g. Wannan yana nuna cewa ko da lokacin da matakan FC suka zama al'ada, wasu marasa lafiya ƙila ba su sami warkarwa ta endoscopic ba, kuma har yanzu ba za a iya maye gurbin colonoscopy gaba ɗaya ba.
Kammalawar Bincike
- Gano FC da aka yi da FICA yana da kyakkyawan hasashen ayyukan asibiti da endoscopic a cikin UC.
- Ana ba da shawarar rage kashi 57.38 μg/g don tantance ayyukan asibiti.
- Ana ba da shawarar rage kashi 53.30 μg/g don tantance aikin endoscopic (ƙananan matakan suna taimakawa wajen inganta jin zafi).
- FC na iya rage gwajin colonoscopy ɗin da ba dole ba yadda ya kamata da kuma inganta amfani da albarkatun likita.
Inganta Ganewar Ganewa Mai Kyau da Maganin IBD-Baysen a Aiki
Kamfanin Xiamen Baysen Medical ya haɓaka shi da kansaKit ɗin Gwajin Calprotectin (Gwajin Immunochromatography na Fluorescence) da kumaMai Nazarin Immunoassay Mai Ci Gaba na WIZ-A202bayar da fa'idodi masu zuwa:
Kayan Gwajin Calprotectin (Gwajin Immunochromatography na Fluorescence)
Matsayi: Gwajin Adadin Asibiti
FICA tana amfani da hanyar sandwich mai hana garkuwar jiki guda biyu don gano FC, tana nuna kyakkyawar alaƙa da ELISA, kuma tana iya tantance ayyukan IBD yadda ya kamata.
Amfanin Samfuri:
- Sauri da Sauƙi:Ana samun sakamako cikin mintuna 15 kacal
- Sauƙin Aiki: Ba a buƙatar kayan aiki masu rikitarwa; ya dace da cibiyoyin kiwon lafiya a kowane mataki
- Sakamako Masu Inganci:Kyakkyawan alaƙa da aikin asibiti da endoscopic
- Bukatun Samfura Masu Sharewa: Tsarin ɗaukar samfuri mai daidaito yana tabbatar da ingancin gwaji
Aikace-aikace:Duba marasa lafiya a waje, sa ido kan marasa lafiya a asibiti, bin diddigin magani, da haɗin gwiwar bincike
Amfanin Samfuri:
- Cikakken Daidaita Nau'in Samfura: Yana iya gwada samfuran jini, fitsari, da najasa
- Kyakkyawan Daidaituwa: Yana ɗaukar hanyar colloidal gold, hanyar latex, da kuma gwajin immunoassay na fluorescence
- Lafiyar Halitta:Tattara katunan sharar gida ta atomatik don zubar da su cikin sauƙi da aminci
- Ci gaba da Samfur:An sanye shi da ɗakin shiryawa mai matsayi da yawa, wanda ke ba da damar ɗaukar samfuri da gwaji ba tare da katsewa ba
- Ganewar Hankali: Yana gano abubuwan gwaji da hanyar aiki ta atomatik
- Haɗakar Bayanai:Yana tallafawa haɗi da LIS na asibiti (Tsarin Bayanan Dakin Gwaji)
Wannan binciken ya tabbatar da mahimmancin mahimmancin ganewar FICA-based FC a cikin kulawar UC, yana ba da kayan aiki mai ƙarfi don sa ido ba tare da ɓata lokaci ba ga marasa lafiya na IBD.
A duk duniya, yawan kamuwa da cutar IBD yana ƙaruwa akai-akai. Gano cutar da wuri, magani mai daidaito, da kuma sa ido kan kimiyya sune mabuɗin inganta sakamakon marasa lafiya. A matsayin wani abu mai nuna alama mara cutarwa, mai dacewa, kuma mai takamaiman takamaiman alama, calprotectin na fecal yana canza tsarin kula da cututtuka na IBD.
Mu Baysen/Wizbiotech mun ci gaba da jajircewa wajen bincike da inganta kayayyakin bincike da suka shafi IBD, muna samar wa likitoci da marasa lafiya hanyoyin gwaji mafi inganci da dacewa, da kuma yin aiki tare don kare lafiyar hanji.
Lokacin Saƙo: Mayu-19-2026