Meyi 19 ndi Tsiku la Padziko Lonse la IBD, yodzipereka kudziwitsa anthu za matenda otupa m'matumbo (IBD) komanso kusamalira odwala a IBD. IBD imaphatikizapo makamaka ulcerative colitis (UC) ndi matenda a Crohn (CD). Ndi matenda osatha, otupa m'matumbo omwe amabwereranso omwe amawononga kwambiri moyo wa odwala. Pa nthawiyi, tikusangalala kugawana kafukufuku waposachedwa wochitidwa ndi Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, omwe adagwiritsa ntchitoKiti Yoyesera ya Calprotectin(Kuyesa kwa Fluorescence Immunochromatography, FICA)ndiChowunikira Chosalekeza cha WIZ-A202 Chosalekezayopangidwa ndi ife, yopereka maumboni ofunikira pakuwongolera matenda a odwala a UC.
Mbiri Yofufuzira: Kufunafuna Zizindikiro Zabwino Zowunikira Zosasokoneza za UC
Colonoscopy ndiye "muyezo wabwino kwambiri" wowunikira momwe matenda a endoscopic amagwirira ntchito mu UC, koma ndi yovuta ndipo odwala sailola bwino, zomwe zimapangitsa kuti kuyang'aniridwa pafupipafupi kukhale kovuta. Zizindikiro za seramu mongaPuloteni yogwira ntchito ya C (CRP) ndipo kuchuluka kwa erythrocyte sedimentation rate (ESR) sikudziwika bwino ndipo sikukugwirizana bwino ndi kutupa kwa m'mimba.
Fecal calprotectin (FC), chizindikiro cha kutupa m'matumbo chomwe chimachokera ku ma neutrophils, chakhala chida chofunikira kwambiri chosamalira IBD. Komabe, malire a FC amasiyana kwambiri panjira zosiyanasiyana zodziwira matenda chifukwa cha kusowa kwa miyezo yokhazikika yodulira. Kuyesa kwa Fluorescence immunochromatography (FICA) ndi njira yodziwira matenda mwachangu komanso mosavuta, koma miyezo yake yabwino kwambiri yodulira matenda imafuna kutsimikiziridwa kwina.
Zolinga ndi Njira Zofufuzira
1) Zolinga Zofufuzira: Kafukufukuyu cholinga chake chinali kuwunika mgwirizano pakati pa FC yomwe yapezeka ndi FICA ndi zochitika zachipatala/za endoscopic matenda mu UC, ndikupeza mfundo zabwino kwambiri zodziwira zomwe zikuchitika pa matenda.
2） Chiwerengero cha Ofufuza: Odwala 110 omwe adapezeka ndi UC omwe adagonekedwa m'chipatala ku Union Hospital, Tongji Medical College, Huazhong University of Science and Technology pakati pa Januware 2021 ndi Juni 2022.
3） Njira Yodziwira: FC idayesedwa pogwiritsa ntchitoChowunikira Chosalekeza cha WIZ-A202 Chosalekeza ndi kufananizaKiti ya Calprotectin FICAkuchokera kwa ife
4）Zimene Ziyenera Kuganiziridwa: Ntchito yachipatala inayesedwa pogwiritsa ntchito chiŵerengero cha Mayo (pMS); ntchito ya endoscopic inayesedwa pogwiritsa ntchito Ulcerative Colitis Endoscopic Index of Severity (UCEIS) ndi Mayo Endoscopic Score (MES).
Zotsatira za Kafukufuku Waukulu
1. Miyezo ya FC imagwirizana kwambiri ndi ntchito ya matenda.
Magawo a FC adawonetsa kulumikizana kwakukulu ndi pMS (r=0.609), UCEIS (r=0.751), ndi MES (r=0.635) (onse P<0.001), ndi kulumikizana kwabwino kuposaCRPndi ESR. Kugwirizana pakati pa FC ndi ntchito ya endoscopic kunali kwakukulu kwambiri.
2. Makhalidwe abwino kwambiri odulira mtengo amatsimikiziridwa.
| Cholinga Cholosera | Kudula bwino kwambiri (μg/g) | Kuzindikira | Kufotokozera Mwapadera |
|---|---|---|---|
| Zochita zachipatala (pMS ≥ 3) | ≥57.38 | 78.02% | 100% |
| Ntchito ya Endoscopic (UCEIS ≥ 1 / MES ≥ 1) | ≥53.30 | 71.57–73.74% | 100% |
3. FC yawonetsa bwino kwambiri pakusankha UC yogwira ntchito.
Kusanthula kwa ROC curve kunasonyeza kuti AUC ya FC yolosera zochitika zachipatala inali 0.9456, ndipo polosera zochitika za endoscopic inali 0.9075 (UCEIS) ndi 0.9118 (MES), zonse zinali zabwino kwambiri kuposa CRP ndi ESR.
4. Kuchotsedwa kwa matenda sikutanthauza kuchotsedwa kwa endoscopic.
Mwa odwala 11 omwe adakwanitsa kuchira (pMS <3) koma anali ndi ntchito ya endoscopic, 10 (90.91%) anali ndi milingo ya FC pansi pa 53.30 μg/g. Izi zikusonyeza kuti ngakhale milingo ya FC ili bwino, odwala ena mwina sanathe kuchira endoscopic, ndipo colonoscopy singathe kusinthidwa kwathunthu.
Mapeto a Kafukufuku
- Kuzindikira kwa FC komwe kumachokera ku FICA ndi chizindikiro chabwino cha ntchito zachipatala ndi endoscopic mu UC.
- Kuchepetsa kwa 57.38 μg/g kumalimbikitsidwa poyesa ntchito zachipatala.
- Kuchepetsa kwa 53.30 μg/g kumalimbikitsidwa poyesa ntchito ya endoscopic (mlingo wocheperako umathandiza kukonza kukhudzidwa kwa khungu).
- FC imatha kuchepetsa bwino ma colonoscopy osafunikira ndikuwonjezera kugwiritsa ntchito bwino zinthu zachipatala.
Kupititsa patsogolo Kuzindikira Molondola ndi Kuchiza IBD-Baysen Ikugwira Ntchito
Xiamen Baysen Medical idapangidwa payokhaKiti Yoyesera ya Calprotectin (Kuyesa kwa Fluorescence Immunochromatography) ndiChowunikira Chosalekeza cha WIZ-A202 Chosalekezakupereka ubwino wotsatira:
Kiti Yoyesera ya Calprotectin (Kuyesa kwa Fluorescence Immunochromatography)
Malo: Kuyesa Kuchuluka kwa Zachipatala
FICA imagwiritsa ntchito njira ya sandwich ya ma double-antibody kuti izindikire FC, imasonyeza mgwirizano wabwino ndi ELISA, ndipo imatha kuwunika bwino momwe IBD imagwirira ntchito.
Ubwino wa Zamalonda:
- Mwachangu komanso Mosavuta:Zotsatira zikupezeka mu mphindi 15 zokha
- Ntchito YosavutaPalibe zida zovuta zomwe zimafunika; zoyenera mabungwe azachipatala pamlingo uliwonse
- Zotsatira Zodalirika:Kugwirizana kwabwino ndi ntchito zachipatala ndi endoscopic
- Zofunikira za Zitsanzo Zomveka BwinoNjira yokhazikika yopezera zitsanzo imatsimikizira mtundu wa mayeso
Mapulogalamu:Kuwunika odwala akunja, kuyang'anira odwala omwe ali m'chipatala, kutsatira chithandizo, komanso kugwirira ntchito limodzi ndi kafukufuku
Ubwino wa Zamalonda:
- Kugwirizana Kwathunthu kwa Mtundu wa Zitsanzo: Wokhoza kuyesa magazi, mkodzo, ndi ndowe
- Kugwirizana Kwabwino: Imathandizira njira ya colloidal gold, njira ya latex, ndi fluorescence immunoassay
- Zotetezeka mwachilengedwe:Kusonkhanitsa makadi otayira zinyalala okha kuti azitha kutaya mosavuta komanso motetezeka
- Kupereka Zitsanzo Mosalekeza:Yokhala ndi chipinda chosungiramo zinthu zambiri, chomwe chimalola kunyamula ndi kuyesa zitsanzo mosalekeza
- Kuzindikira Mwanzeru: Amazindikira zokha zinthu zoyeserera ndi njira zoyesera
- Kugwirizana kwa Deta:Imathandizira kulumikizana ndi LIS yachipatala (Laboratory Information System)
Kafukufukuyu akutsimikizira kufunika kwa kuzindikira kwa FICA-based FC mu kasamalidwe ka UC, zomwe zimapereka chida champhamvu chowunikira odwala a IBD mosasokoneza.
Padziko lonse lapansi, kuchuluka kwa anthu omwe ali ndi IBD kukuchulukirachulukira. Kuzindikira matenda msanga, chithandizo chokhazikika, ndi kuyang'anira mwasayansi ndizofunikira kwambiri pakukweza zotsatira za odwala. Monga chizindikiro chosavulaza, chosavuta, komanso chodziwika bwino, fecal calprotectin ikusintha njira yothanirana ndi matenda a IBD.
Ife Baysen/Wizbiotech tikupitirizabe kudzipereka pakufufuza ndi kukonza bwino zinthu zokhudzana ndi matenda a IBD, kupatsa madokotala ndi odwala njira zoyesera zolondola komanso zosavuta, komanso kugwira ntchito limodzi kuti titeteze thanzi la m'mimba.
Nthawi yotumizira: Meyi-19-2026