Ko te 19 o Mei te Rā o te Ao mō te IBD, e whakatapua ana ki te whakapiki i te mōhiotanga o te marea mō te mate puku mumura (IBD) me te tiaki i ngā tūroro IBD. Ko te nuinga o te IBD ko te mate puku ulcerative (UC) me te mate a Crohn (CD). He mate puku mumura mau tonu, ka hoki whakamuri, e tino whakararu ana i te kounga o te oranga o ngā tūroro. I tēnei wā, e harikoa ana mātou ki te whakapuaki i tētahi rangahau hou i whakahaerehia e te Hōhipera Union, Tongji Medical College, Huazhong University of Science and Technology, i whakamahi i teKete Whakamātautau Calprotectin(Whakamātautau Ārai Matū Whakapūngao Hiko, FICA)me teWIZ-A202 Tātari Immuneassay Tonui whakawhanakehia e mātou, e whakarato ana i ngā tohutoro nui mō te whakahaere i te mate o ngā tūroro UC.
Papamuri Rangahau: Te Rapu i ngā Tohu Aroturuki Kore-whakaekenga Pai ake mō te UC
Ko te colonoscopy te "paerewa koura" mō te aromatawai i te mahi a te mate endoscopic i roto i te UC, engari he mea whakaeke, ā, kāore e taea e ngā tūroro te aro atu, ka uaua ai te aroturuki i ia wā. Ko ngā tohu toto pēnei i tePūmua C-tauhohe (CRP) ā, kāore i te tino motuhake te tere o te whakatōtō erythrocyte (ESR), ā, he kino te hononga ki te mumura o te puku.
Te calprotectin paru (FC), he tohu mumura motuhake ki te whekau i ahu mai i ngā neutrophils, kua noho hei taputapu nui kore-whakaeke i roto i te whakahaere IBD. Heoi, he rerekē rawa ngā paepae FC puta noa i ngā tikanga kimi rerekē nā te kore o ngā uara tapahi paerewa. He tikanga kimi tere, he māmā hoki te whakamātautau immunochromatography fluorescence (FICA), engari me whakamana anō ōna uara tapahi haumanu tino pai.
Ngā Whāinga me ngā Tikanga Rangahau
1) Ngā Whāinga Rangahau: Ko te whāinga o tēnei rangahau he aromatawai i te hononga i waenga i te FC i kitea e te FICA me te mahi mate haumanu/endoscopic i roto i te UC, me te whakatau i ngā uara tapahi tino pai mō te matapae i te mahi mate.
2）Taupori Rangahau: 110 ngā tūroro i kitea he UC i whakaurua ki te hōhipera i te Hōhipera Union, Tongji Medical College, Huazhong University of Science and Technology i waenga i te Hanuere 2021 me te Pipiri 2022.
3）Tikanga Kimi: I inehia te FC mā te whakamahi i teWIZ-A202 Tātari Immuneassay Tonu me te whakatauriteKete Calprotectin FICAmai i a mātou
4) Paearu Aromatawai: I aromatawaihia te mahi haumanu mā te kaute Mayo wāhanga (pMS); i aromatawaihia te mahi endoscopic mā te Ulcerative Colitis Endoscopic Index of Severity (UCEIS) me te Mayo Endoscopic Score (MES).
Ngā Hua Rangahau Matua
1. He hononga nui tō ngā taumata FC ki te kaha o te mate.
I whakaatuhia e ngā taumata FC he hononga pai nui ki te pMS (r=0.609), UCEIS (r=0.751), me te MES (r=0.635) (katoa P<0.001), me te hononga pai ake i teCRPme te ESR. He tino kaha te hononga i waenga i te FC me te mahi endoscopic.
2. Kua whakatauhia ngā uara tapahi tino pai.
| Whāinga Matapae | Te tapahi tino pai (μg/g) | Te aro nui | Te motuhaketanga |
|---|---|---|---|
| Ngā mahi haumanu (pMS ≥ 3) | ≥57.38 | 78.02% | 100% |
| Te mahi endoscopic (UCEIS ≥ 1 / MES ≥ 1) | ≥53.30 | 71.57–73.74% | 100% |
3. I whakaatu a FC i te mahi tino pai ki te wehewehe i te UC hohe.
I whakaatuhia e te tātaritanga pihi ROC ko te AUC o FC mō te matapae i ngā mahi haumanu he 0.9456, ā, mō te matapae i ngā mahi endoscopic he 0.9075 (UCEIS) me te 0.9118 (MES), he pai ake katoa i te CRP me te ESR.
4. Kāore te murunga haumanu e rite ana ki te murunga endoscopic.
I roto i ngā tūroro 11 i whiwhi i te whakaoranga haumanu (pMS < 3) engari kei te mau tonu te mahi endoscopic, 10 (90.91%) he iti iho i te 53.30 μg/g ngā taumata FC. E whakaatu ana tēnei ahakoa he noa ngā taumata FC, kāore pea ētahi tūroro i whiwhi i te whakaora endoscopic, ā, kāore tonu e taea te whakakapi katoa i te colonoscopy.
Ngā Whakatau Rangahau
- He tohu pai te kitenga FC e hangai ana ki te FICA mō ngā mahi haumanu me ngā mahi endoscopic i roto i te UC.
- E taunakitia ana kia 57.38 μg/g te taumata hei aromatawai i ngā mahi haumanu.
- E taunakitia ana kia whakamahia he paenga iti iho i te 53.30 μg/g hei aromatawai i te mahi endoscopic (mā te paepae iti ka pai ake te aro).
- Ka taea e te FC te whakaiti i ngā colonoscopie kore e hiahiatia, me te arotau i te whakamahinga o ngā rauemi hauora.
Te Whakatairanga i te Tātaritanga me te Maimoatanga Tika o te IBD-Baysen i roto i te Mahi
I whakawhanakehia motuhaketia a Xiamen Baysen MedicalKete Whakamātautau Calprotectin (Whakamātautau Ārai Materomatora Hikorangi) me teWIZ-A202 Tātari Immuneassay Tonue tuku ana i ngā painga e whai ake nei:
Kete Whakamātautau Calprotectin (Whakamātautau Immunochromatography Fluorescence)
Te Tūnga: Te Whakamātautau Tauanga Hauora
Ka whakamahia e te FICA he tikanga hanawiti paturopi-rua hei kite i te FC, he hononga pai ki te ELISA, ā, ka taea te aromatawai tika i ngā mahi IBD.
Ngā Painga o te Hua:
- Tere me te Māmā:Ka puta ngā hua i roto i te 15 meneti noa iho
- Ngāwari te whakahaereKāore e hiahiatia he taputapu uaua; he pai mō ngā whare hauora o ngā taumata katoa
- Ngā Hua Pono:He hononga pai ki te mahi haumanu me te mahi endoscopic
- Ngā Whakaritenga Tauira MāramaMā te tukanga tauira paerewa ka whakarite i te kounga o te whakamātautau
Ngā tono:Te tirotiro i waho o te tūroro, te aroturuki i roto i te tūroro, te whai i te maimoatanga, me te mahi tahi rangahau
Ngā Painga o te Hua:
- Hototahitanga Momo Tauira KatoaKa taea te whakamātautau i te toto, te mimi, me ngā tauira paru
- Hototahi PaiE tautoko ana i te tikanga koura colloidal, te tikanga latex, me te whakamātautau ārai mate fluorescence
- Haumaru ā-koiora:Kohikohi kāri para aunoa mō te tukunga watea me te haumaru
- Te Tauira Tonu:He rūma whakatō maha-tūranga, e āhei ai te uta tauira me te whakamātautau kore e mutu
- Te Mōhiotanga Maamaa: Ka tautuhi aunoa i ngā tūemi whakamātautau me te tikanga mahi
- Te Mahitahi Raraunga:Tautoko i te hononga ki te LIS hōhipera (Pūnaha Mōhiohio Taiwhanga)
E whakaū ana tēnei rangahau i te uara haumanu nui o te kimi FC e hangai ana ki te FICA i roto i te whakahaere UC, e whakarato ana i tētahi taputapu kaha mō te aroturuki kore-whakaekenga o ngā tūroro IBD.
Kei te piki haere tonu te maha o ngā tāngata e pāngia ana e te IBD puta noa i te ao. Ko te tautuhi wawe, te maimoatanga paerewa, me te aroturuki pūtaiao he mea nui ki te whakapai ake i ngā putanga o ngā tūroro. Hei tohu koiora kore-whakaeke, watea, me te tino motuhake, kei te hurihia e te fecal calprotectin te tauira whakahaere mate mō te IBD.
Kei te mau tonu mātou, a Baysen/Wizbiotech, ki te rangahau me te arotau i ngā hua tātaritanga e pā ana ki te IBD, me te whakarato i ngā otinga whakamātautau tika ake, watea ake hoki ki ngā tākuta me ngā tūroro, me te mahi tahi ki te tiaki i te hauora o te puku.
Wā tuku: Mei-19-2026