ʻO ka lā 19 o Mei ka lā IBD o ke ao holoʻokoʻa, i hoʻolaʻa ʻia no ka hoʻomaopopo ʻana i ka lehulehu i ka maʻi ʻōpū mumū (IBD) a me ka mālama ʻana i nā maʻi IBD. ʻO ka IBD ka mea nui e pili ana i ka ulcerative colitis (UC) a me ka maʻi Crohn (CD). He maʻi ʻōpū mumū mau loa ia e hoʻihoʻi hou ana e hoʻopilikia nui ana i ke ʻano o ke ola o nā maʻi. I kēia manawa, hauʻoli mākou e kaʻana like i kahi noiʻi noiʻi hou loa i mālama ʻia e ka Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, nāna i hoʻohana i kaPahu Hoʻāʻo Calprotectin(Fluorescence Immunochromatography Assay, FICA)a me kaMea loiloi Immunoassay hoʻomau WIZ-A202i hoʻomohala ʻia e mākou, e hāʻawi ana i nā kuhikuhi koʻikoʻi no ka mālama ʻana i nā maʻi o nā maʻi UC.
Ka Moolelo Noiʻi: Ke ʻimi nei i nā ʻōkuhi nānā ʻoi aku ka maikaʻi no UC
ʻO ka Colonoscopy ke "kūlana gula" no ka loiloi ʻana i ka hana maʻi endoscopic ma UC, akā he invasive a ʻae ʻole ʻia e nā maʻi, e paʻakikī ai ka nānā pinepine ʻana. ʻO nā māka serum e like meʻO ka protein C-reactive (CRP) a me ka nele o ka erythrocyte sedimentation rate (ESR) i ke ʻano kūikawā a pili maikaʻi ʻole me ka mumū ʻōpū.
ʻO ka calprotectin fecal (FC), kahi māka mumū kikoʻī i loaʻa mai nā neutrophils, ua lilo i mea hana koʻikoʻi ʻaʻole invasive i ka hoʻokele IBD. Eia nō naʻe, ʻokoʻa loa nā paepae FC ma nā ʻano ʻike like ʻole ma muli o ka nele o nā waiwai ʻoki maʻamau. ʻO ka fluorescence immunochromatography assay (FICA) kahi ʻano ʻike wikiwiki a maʻalahi hoʻi, akā ʻo kāna mau waiwai ʻoki lapaʻau kūpono e pono ai ka hōʻoia hou aku.
Nā Pahuhopu a me nā ʻAno Hana Noiʻi
1) Nā Pahuhopu Noiʻi: Ua manaʻo kēia haʻawina e loiloi i ka pilina ma waena o ka FC i ʻike ʻia e FICA a me ka hana maʻi lapaʻau/endoscopic ma UC, a e hoʻoholo i nā waiwai ʻoki kūpono no ka wānana ʻana i ka hana maʻi.
2) Helu o ke Aʻo ʻana: 110 mau maʻi i ʻike ʻia me ka UC i hoʻokipa ʻia ma ka Halemai Union, Tongji Medical College, Huazhong University of Science and Technology ma waena o Ianuali 2021 a me Iune 2022.
3）ʻAno ʻIke: Ua ana ʻia ʻo FC me ka hoʻohana ʻana i kaMea loiloi Immunoassay hoʻomau WIZ-A202 a me ka hoʻohālikelike ʻanaPahu FICA Calprotectinmai iā mākou
4) Nā Kūlana Loiloi: Ua loiloi ʻia ka hana lapaʻau e ka helu Mayo hapa (pMS); ua loiloi ʻia ka hana endoscopic e ka Ulcerative Colitis Endoscopic Index of Severity (UCEIS) a me Mayo Endoscopic Score (MES).
Nā Hualoaʻa Noiʻi Koʻikoʻi
1. Ua pili pono nā pae FC me ka hana maʻi.
Ua hōʻike nā pae FC i nā pilina maikaʻi koʻikoʻi me pMS (r = 0.609), UCEIS (r = 0.751), a me MES (r = 0.635) (ʻo P <0.001 āpau), me ka pilina maikaʻi ma mua oCRPa me ESR. Ua ikaika loa ka pilina ma waena o FC a me ka hana endoscopic.
2. Ua hoʻoholo ʻia nā waiwai ʻoki kūpono loa.
| Pahuhopu Wānana | ʻOki kūpono loa (μg/g) | ʻIkepili | Kūlana kikoʻī |
|---|---|---|---|
| Hana lapaʻau (pMS ≥ 3) | ≥57.38 | 78.02% | 100% |
| Hana Endoscopic (UCEIS ≥ 1 / MES ≥ 1) | ≥53.30 | 71.57–73.74% | 100% |
3. Ua hōʻike ʻo FC i ka hana maikaʻi loa i ka hoʻokaʻawale ʻana i ka UC hana.
Ua hōʻike ka loiloi piʻo ROC ʻo ka AUC o FC no ka wānana ʻana i ka hana lapaʻau he 0.9456, a no ka wānana ʻana i ka hana endoscopic he 0.9075 (UCEIS) a me 0.9118 (MES), ʻoi aku ka maikaʻi ma mua o CRP a me ESR.
4. ʻAʻole like ke kala ʻana o ka lāʻau lapaʻau me ke kala ʻana endoscopic.
Ma waena o nā maʻi he 11 i loaʻa ka hoʻomaha lapaʻau (pMS < 3) akā loaʻa nō ka hana endoscopic, 10 (90.91%) i loaʻa nā pae FC ma lalo o 53.30 μg/g. Hōʻike kēia ʻoiai inā maʻamau nā pae FC, ʻaʻole paha i loaʻa i kekahi mau maʻi ka ho'ōla endoscopic, a ʻaʻole hiki ke hoʻololi piha ʻia ka colonoscopy.
Nā Hopena Noiʻi
- ʻO ka ʻike ʻana iā FC e pili ana iā FICA he mea wānana maikaʻi ia o ka hana lapaʻau a me ka hana endoscopic ma UC.
- Manaʻo ʻia kahi ʻoki o 57.38 μg/g no ka loiloi ʻana i ka hana lapaʻau.
- Manaʻo ʻia kahi ʻoki o 53.30 μg/g no ka loiloi ʻana i ka hana endoscopic (kōkua ka paepae haʻahaʻa i ka hoʻomaikaʻi ʻana i ka ʻike).
- Hiki i ka FC ke hōʻemi pono i nā colonoscopies pono ʻole a hoʻonui i ka hoʻohana ʻana i nā kumuwaiwai lapaʻau.
Ke Hoʻolaha nei i ka ʻIke Kūpono a me ka Lapaʻau ʻana o IBD-Baysen ma ka Hana
Ua hoʻomohala kūʻokoʻa ʻia ʻo Xiamen Baysen MedicalPahu Hoʻāʻo Calprotectin (Fluorescence Immunochromatography Assay) a meMea loiloi Immunoassay hoʻomau WIZ-A202hāʻawi i nā pono aʻe:
Pahu Hoʻāʻo Calprotectin (Hoʻāʻo Fluorescence Immunochromatography)
Ke Kūlana: Hoʻāʻo ʻana i ka helu lapaʻau
Hoʻohana ʻo FICA i kahi ʻano sandwich antibody pālua e ʻike ai iā FC, hōʻike i ka pilina maikaʻi me ELISA, a hiki ke loiloi pono i ka hana IBD.
Nā Pōmaikaʻi Huahana:
- Wikiwiki a maʻalahi hoʻi:Loaʻa nā hopena i loko o 15 mau minuke wale nō
- Hana maʻalahiʻAʻohe pono o nā lako paʻakikī; kūpono no nā ʻoihana lapaʻau ma nā pae āpau
- Nā Hopena Hilinaʻi:ʻO ka pilina maikaʻi me ka hana lapaʻau a me ka hana endoscopic
- Nā Koina Laʻana Hoʻomaopopo: Hōʻoia ka hana laʻana maʻamau i ka maikaʻi o ka hoʻāʻo ʻana
Nā noi:Ka nānā ʻana i ka maʻi ma waho, ka nānā ʻana i ka maʻi ma loko, ka hahai ʻana i ka lāʻau lapaʻau, a me ka laulima noiʻi
Nā Pōmaikaʻi Huahana:
- Hoʻohālikelike ʻAno Laʻana PihaHiki ke hoʻāʻo i ke koko, ka mimi, a me nā hāpana fecal
- Hoʻohālikelike maikaʻiHoʻokipa i ke ʻano gula colloidal, ke ʻano latex, a me ka immunoassay fluorescence
- Palekana Olaola:ʻOhi kāleka ʻōpala aunoa no ka hoʻolei maʻalahi a palekana hoʻi
- Laʻana Hoʻomau:Hoʻolako ʻia me kahi keʻena hoʻomoʻa multi-position, e hiki ai ke hoʻouka a me ka hoʻāʻo ʻana i ka laʻana me ka ʻole o ka hoʻopaʻa ʻana
- ʻIke akamai: Hoʻomaopopo ponoʻī i nā mea hoʻāʻo a me ke ʻano hana
- Ka Hana like ʻana o ka ʻikepili:Kākoʻo i ka pilina me ka haukapila LIS (Laboratory Information System)
Ua hōʻoia kēia haʻawina i ka waiwai koʻikoʻi o ka ʻike ʻana o ka FC ma muli o FICA i ka hoʻokele UC, e hāʻawi ana i kahi mea hana ikaika no ka nānā ʻana i nā poʻe maʻi IBD me ka ʻole o ka invasive.
Ma ka honua holoʻokoʻa, ke piʻi mau nei ka nui o ka IBD. ʻO ka ʻike mua ʻana, ka mālama maʻamau, a me ka nānā ʻepekema nā mea nui i ka hoʻomaikaʻi ʻana i nā hopena o ka mea maʻi. Ma ke ʻano he biomarker non-invasive, kūpono, a kikoʻī loa, ke hoʻololi nei ka fecal calprotectin i ke kumu hoʻohālike hoʻokele maʻi no IBD.
ʻO mākou ʻo Baysen/Wizbiotech, ke kūpaʻa nei mākou i ka noiʻi a me ka hoʻonui ʻana i nā huahana diagnostic e pili ana i ka IBD, e hāʻawi ana i nā kauka a me nā mea maʻi me nā hopena hoʻāʻo pololei a maʻalahi hoʻi, a e hana pū ana e pale i ke olakino ʻōpū.
Ka manawa hoʻouna: Mei-19-2026