Chivabvu 19 izuva reWorld IBD Day, yakatsaurirwa kusimudzira ruzivo rweveruzhinji nezvechirwere chemudumbu chinozvimba (IBD) uye kutarisira varwere veIBD. IBD inonyanya kusanganisira ulcerative colitis (UC) nechirwere cheCrohn (CD). Ichirwere chemudumbu chinodzoka chisingaperi, chinodzokororwa chinokanganisa hupenyu hwevarwere zvakanyanya. Pachiitiko ichi, tinofara kugovera chidzidzo chitsva chakaitwa neUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, iyo yakashandisaKiti Yekuyedza Calprotectin(Kuyedzwa kweFluorescence Immunochromatography, FICA)uyeWIZ-A202 Inoenderera Mberi Inoongorora Immunoassayyakagadzirwa nesu, ichipa magwaro akakosha ekurapa chirwere chevarwere veUC.
Nhoroondo Yekutsvagisa: Kutsvaga Zviratidzo Zviri Nani Zvekutarisa Zvisingapindi Muropa zveUC
Colonoscopy ndiyo "nzira yepamusoro" yekuongorora mashandiro echirwere che endoscopic muUC, asi inopararira uye haitenderwi zvakanaka nevarwere, zvichiita kuti kuongororwa nguva nenguva kuve kwakaoma. Zviratidzo zve serum zvakaita seMapuroteni eC-reactive (CRP) uye chiyero che erythrocyte sedimentation (ESR) hachina kunyatsojeka uye hachina hukama hwakanaka nekuzvimba kwemudumbu.
Fecal calprotectin (FC), chiratidzo chekuzvimba chinobva muma neutrophils, chave chishandiso chakakosha chisingapindi muropa mukurapa IBD. Zvisinei, FC thresholds dzinosiyana zvakanyanya munzira dzakasiyana dzekuona nekuda kwekushaikwa kwemaitiro akajairwa ekucheka. Fluorescence immunochromatography assay (FICA) inzira yekuona nekukurumidza uye iri nyore, asi maitiro ayo ekucheka ekiriniki akanakisa anoda kusimbiswa zvakanyanya.
Zvinangwa uye Nzira dzeKutsvaga
1) Zvinangwa zveKutsvagurudza: Chidzidzo ichi chaive nechinangwa chekuongorora hukama huripo pakati peFC yakaonekwa neFICA uye chiitiko chekiriniki/endoscopic chirwere muUC, uye kuona huwandu hwakakodzera hwekufanotaura chiitiko chechirwere.
2）Vanhu vekudzidza: Varwere zana negumi vakaonekwa vaine UC vakaiswa muchipatara paUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology pakati paNdira 2021 naChikumi 2022.
3） Nzira yekuona: FC yakayerwa uchishandisaWIZ-A202 Inoenderera Mberi Inoongorora Immunoassay uye kuenderanaKiti yeCalprotectin FICAkubva kwatiri
4）Zvinhu zveKuongorora: Basa rekurapa rakaongororwa nechikamu cheMayo score (pMS); basa re endoscopic rakaongororwa neUlcerative Colitis Endoscopic Index of Severity (UCEIS) uye Mayo Endoscopic Score (MES).
Mhedzisiro Yekutsvagisa Kwakakosha
1. Mazinga eFC akabatana zvakanyanya nekushanda kwechirwere.
Mazinga eFC akaratidza hukama hwakanaka ne pMS (r=0.609), UCEIS (r=0.751), uye MES (r=0.635) (zvose P<0.001), nehukama huri nani kupfuuraCRPuye ESR. Hukama huripo pakati peFC nebasa re endoscopic hwaive hwakasimba zvikuru.
2. Hunhu hwakanaka hwekucheka hunotsanangurwa.
| Chinangwa Chekufanotaura | Kucheka kwakakodzera (μg/g) | Kunzwisisa | Kunyatsojeka |
|---|---|---|---|
| Chiitiko chekurapa (pMS ≥ 3) | ≥57.38 | 78.02% | 100% |
| Basa reEndoscopic (UCEIS ≥ 1 / MES ≥ 1) | ≥53.30 | 71.57–73.74% | 100% |
3. FC yakaratidza kushanda zvakanaka mukusarura UC inoshanda.
Ongororo yeROC curve yakaratidza kuti AUC yeFC yekufanotaura zviitiko zvekiriniki yaive 0.9456, uye yekufanotaura zviitiko zve endoscopic yaive 0.9075 (UCEIS) uye 0.9118 (MES), zvese zviri nani kupfuura CRP neESR.
4. Kuregererwa kwekiriniki hakuenzani nekuregererwa kwe endoscopic.
Pakati pevarwere gumi nerimwe vakawana relieval yekiriniki (pMS <3) asi vachiri ne endoscopy activity, gumi (90.91%) vaiva ne FC levels iri pasi pe53.30 μg/g. Izvi zvinoratidza kuti kunyangwe kana FC levels dziri dzakanaka, vamwe varwere vangave vasina kuwana endoscopy kuporesa, uye colonoscopy haigone kutsiviwa zvachose.
Mhedziso dzeKutsvagurudza
- Kuongororwa kweFC kwakavakirwa paFICA inzira yakanaka yekuratidza mashandiro ekurapa uye endoscopic muUC.
- Kuderedza 57.38 μg/g kunokurudzirwa pakuongorora mashandiro ekiriniki.
- Kuderedza 53.30 μg/g kunokurudzirwa pakuongorora mashandiro e endoscopic (chiyero chidiki chinobatsira kuvandudza kunzwisisika).
- FC inogona kuderedza colonoscopy dzisiri dzechokwadi uye kugadzirisa kushandiswa kwezviwanikwa zvehutano.
Kufambira Mberi Kuongorora Nekunyatsoongorora uye Kurapa kweIBD-Baysen Inoshanda
Xiamen Baysen Medical yakagadzirwa yakazvimiriraKiti Yekuyedza Calprotectin (Kuyedzwa kweFluorescence Immunochromatography) uyeWIZ-A202 Inoenderera Mberi Inoongorora Immunoassayzvinopa mabhenefiti anotevera:
Kiti Yekuyedza Calprotectin (Fluorescence Immunochromatography Assay)
Kuisa Nzvimbo: Kuongororwa Kwehuwandu hweKliniki
FICA inoshandisa nzira ye double-antibody sandwich kuona FC, inoratidza hukama hwakanaka ne ELISA, uye inogona kunyatsoongorora mashandiro eIBD.
Zvakanakira Chigadzirwa:
- Kukurumidza uye Zviri Nyore:Mhedzisiro inowanikwa mumaminitsi gumi nemashanu chete
- Kushanda Kuri NyoreHapana michina yakaoma inodiwa; yakakodzera kuzvipatara pamatanho ese
- Mhedzisiro Yakavimbika:Kubatana kwakanaka nemabasa ekiriniki uye endoscopic
- Zvinodiwa zvemuenzaniso zvakajeka: Maitiro ekutora sampuro akajairika anovimbisa mhando yekuyedza
Mashandisirwo:Kuongororwa kwevarwere vari kunze, kuongororwa kwevarwere vari mukati, kuteverwa kwekurapwa, uye kushandira pamwe mukutsvaga
Zvakanakira Chigadzirwa:
- Kuenderana Kwakazara Kwemhando Yemuenzaniso: Anokwanisa kuyedza ropa, weti, uye tsvina
- Kuenderana Kwakanaka: Inobatsira nzira ye colloidal gold, nzira ye latex, uye fluorescence immunoassay
- Kuchengetedzwa Kwezvinhu Zvakasiyana:Kuunganidza makadhi emarara otomatiki kuti araswe zviri nyore uye zvakachengeteka
- Kutora Mienzaniso Inoenderera Mberi:Yakashongedzerwa nekamuri yekuchengetera zvirimwa ine nzvimbo dzakawanda, zvichiita kuti kurodha uye kuyedza sampuro kurege kukanganiswa
- Kuzivikanwa Kwakangwara: Inoona otomatiki zvinhu zvebvunzo uye nzira dzekushandisa
- Kushanda pamwe chete kwedata:Inotsigira kubatana neLIS yechipatara (Laboratory Information System)
Chidzidzo ichi chinosimbisa kukosha kwekuongorora kweFICA-based FC mukutarisira UC, zvichipa chishandiso chine simba chekutarisa varwere veIBD vasingakuvadzi.
Pasi rose, kuwanda kwevanhu vane IBD kuri kuramba kuchiwedzera. Kuongororwa kwekutanga, kurapwa kwakajairika, uye kuongororwa nesainzi ndizvo zvakakosha pakuvandudza mhedzisiro yemurwere. Senzira isingakuvadzi, iri nyore, uye yakanyatsotsanangurwa, fecal calprotectin iri kushandura modhi yekugadzirisa chirwere cheIBD.
Isu Baysen/Wizbiotech tinoramba takazvipira kutsvagisa nekugadzirisa zvigadzirwa zvekuongorora zvine chekuita neIBD, tichipa vanachiremba nevarwere mhinduro dzekuongorora dzakarurama uye dziri nyore, uye tichishanda pamwe chete kuchengetedza hutano hwemudumbu.
Nguva yekutumira: Chivabvu-19-2026